MOV10

  • Official Full Name

    Mov10, Moloney leukemia virus 10, homolog (mouse)
  • Overview

    MOV10 may be an helicase with an important function in development and/or control of cell proliferation. RNA silencing processes are guided by small RNAs known as siRNAs and microRNAs (miRNAs). They reside in ribonucleoprotein complexes, which guide the cleavage of complementary mRNAs or affect stability and translation of partial complementary mRNAs. Argonaute (Ago) proteins are at the heart of silencing effector complexes and bind the single-stranded siRNA and miRNA. Ago1- and Ago2-containing complexes have been purified from human cells, resulting in the discovery of novel factors such as the putative RNA helicase MOV10, and the RNA recognition motif (RRM)-containing protein TNRC6B/KIAA1093. The new proteins localize, similar to Ago proteins, to mRNA-degrading cytoplasmic P bodies, and they are functionally required to mediate miRNA-guided mRNA cleavage.
  • Synonyms

    MOV10;Mov10, Moloney leukemia virus 10, homolog (mouse);gb110;fSAP113;putative helicase MOV-10;moloney leukemia virus 10 protein;functional spliceosome-associated protein 113

Recombinant Proteins

  • Human
  • Chicken
  • Rhesus macaque
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
MOV10-946H Recombinant Human MOV10, GST-tagged E.coli Human GST 869-1004aa
MOV10-2067C Recombinant Chicken MOV10 Mammalian Cells Chicken His
MOV10-2809R Recombinant Rhesus monkey MOV10 Protein, His-tagged Mammalian Cells Rhesus macaque His
MOV10-4242HCL Recombinant Human MOV10 293 Cell Lysate HEK293 Human Non
MOV10-1424H Recombinant Human MOV10 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
MOV10-1424H-B Recombinant Human MOV10 Protein Pre-coupled Magnetic Beads HEK293 Human
MOV10-1865H Recombinant Human MOV10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
MOV10-2629R Recombinant Rhesus Macaque MOV10 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
MOV10-2629R-B Recombinant Rhesus Macaque MOV10 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
MOV10-378HFL Active Recombinant Full Length Human MOV10 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
Mov10-4121M Recombinant Mouse Mov10 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
MOV10-6443H Recombinant Human MOV10 protein, His-tagged E.coli Human His 1-1003aa

    Involved Pathway

    MOV10 involved in several pathways and played different roles in them. We selected most pathways MOV10 participated on our site, such as Adaptive Immune System,Beta-catenin independent WNT signaling,Ca2+ pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MOV10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cellular responses to stress NUP35,EED,WIPI1,ATG4A,SUZ12,EPAS1B,KDM6B,LAMTOR2,CABIN1,CDKN2C
    Cellular Senescence HIST1H1E,SUZ12A,LMNB1,RNF2,E2F2,HMGA1,CDKN2A,H3F3D,POT1,HIST1H1B
    Ca2+ pathway GNB5,AGO3,AGO2,AGO1
    DAP12 interactions PAQR3B,FGF8B,DUSP9,SPNA2,FRS3,NEFLB,GRAP2A,CLEC5A,PEBP1,CSF2RB
    Downstream signal transduction RASGRP4,PEBP1,GRB7,PAQR3B,FRS3,PHB,AGO3,RASGEF1A,CNKSR1,SPRED2
    DAP12 signaling AGO2,PAQR3A,CNKSR1,DUSP6,AGO3,CSF2RA,FGF20A,NRG4,RASGRP1,LCP2A
    Adaptive Immune System CSK,TRIM9,LILRB2,CD96,FRS2A,FGF10B,STUB1,TRIM11,TRAF7,DCTN2
    Beta-catenin independent WNT signaling DVL1,AGO2,AGO1,AP2B1,CTNNB2,RYK,AGO3,ROR1,GNB5,DVL2

    Protein Function

    MOV10 has several biochemical functions, for example, ATP binding,helicase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MOV10 itself. We selected most functions MOV10 had, and list some proteins which have the same functions with MOV10. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding CCT6A,YTHDC2,ESF1,LSM4,DHX57,PTRH1,RARS2,NQO1,IPO5,ZFML
    ATP binding MAPK1,MYO19,SMARCA4,CHD2,MYO5B,GK,KITB,GCLC,CSNK1A1,ITPKC
    helicase activity DHX37,WRN,DDX3,MOV10B.2,GTF2F2,SMARCA4,DDX51,PIF1,TDRD12,CHD9
    protein binding ACTN2,BAIAP2,LCORL,USE1,INPPL1,TFAM,LGR5,PTPRZ1,CDC45,CRMP1

    Interacting Protein

    MOV10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MOV10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MOV10.

    YBX1;EIF2AK2;ATG12;PUF60;NS1;CBX4;AIM2;IFIT3;NS;GABARAP;CBX6;NS;US11;IFIT1;Rc3h2;Zfp36;MNDA;HNRNPH2

    Resources

    References

    • Nakano, M; Kakiuchi, Y; et al. MOV10 as a novel telomerase-associated protein. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 388:328-332(2009).
    • Wulczyn, FG; Smirnova, L; et al. Post-transcriptional regulation of the let-7 microRNA during neural cell specification. FASEB JOURNAL 21:415-426(2007).

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