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MRPL28

Official Full Name

mitochondrial ribosomal protein L28
Overview

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion.
Synonyms

MRPL28; mitochondrial ribosomal protein L28; MAAT1, melanoma associated antigen recognised by cytotoxic T lymphocytes; 39S ribosomal protein L28, mitochondrial; p15; 39S ribosomal protein L28 mitochondrial; 39S ribosomal protein L28 mitochondrial precursor; HGNC6756; L28mt; MAAT 1; MAAT1; Melanoma antigen p15; Melanoma associated antigen recognised by cytotoxic T lymphocytes; Melanoma associated antigen recognized by T lymphocytes; MGC8499; MRP L28; MRPL 28; MRP-L28; melanoma-associated antigen recognized by T lymphocytes; melanoma-associated antigen recognised by cytotoxic T lymphocytes;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MRPL28-3024H	Recombinant Human Mitochondrial Ribosomal Protein L28, T7-tagged	E.coli	T7		Inquiry
Human	MRPL28-363H	Recombinant Human mitochondrial ribosomal protein L28, His-tagged	E.coli	His		Inquiry
Human	MRPL28-4182HCL	Recombinant Human MRPL28 293 Cell Lysate	HEK293	Non		Inquiry
Human	MRPL28-5571H	Recombinant Human MRPL28 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MRPL28-4415H	Recombinant Human MRPL28 protein, GST-tagged	E.coli	GST	1-256aa	Inquiry
Human	MRPL28-6435HF	Recombinant Full Length Human MRPL28 Protein, GST-tagged	In Vitro Cell Free System	GST	256 amino acids	Inquiry
Human	MRPL28-5258H	Recombinant Human MRPL28 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Mouse	MRPL28-10057M	Recombinant Mouse MRPL28 Protein	Mammalian Cell	His		Inquiry
Mouse	MRPL28-5693M	Recombinant Mouse MRPL28 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	MRPL28-5693M-B	Recombinant Mouse MRPL28 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Mrpl28-4151M	Recombinant Mouse Mrpl28 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Zebrafish	MRPL28-3004Z	Recombinant Zebrafish MRPL28	Mammalian Cell	His		Inquiry
Chicken	MRPL28-3012C	Recombinant Chicken MRPL28	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

MRPL28 involved in several pathways and played different roles in them. We selected most pathways MRPL28 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL28 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Mitochondrial translation	MRPL54;MRPL38;GADD45GIP1;MRPL44;TUFM;MRPS25;MRPL28;MRPS30;MRPL55
Mitochondrial translation elongation	MRPL40;MRPL51;MRPS23;MRPS22;AURKAIP1;MRPL50;MRPS27;MRPS31;ICT1
Mitochondrial translation initiation	MRPS27;ICT1;CHCHD1;MRPL51;MRPS22;MRPL28;AURKAIP1;DAP3;MTIF3
Mitochondrial translation termination	MRPS24;MRPL49;MRPL42;MRPS25;MRPS27;MRPS30;MRPS26;MRPS23;MRPS36
Organelle biogenesis and maintenance	EXOC5;TNPO1;MRPS22;MARK4;EXOC1;TTBK2;MRPS25;NPHP4;CEP89
Ribosome	MRPL33;MRPL30;MRPL36;MRPL19;RPL6;RPS4X;RPL12;RPL23A;MRPL23

MRPL28 has several biochemical functions, for example, poly(A) RNA binding, protein binding, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL28 itself. We selected most functions MRPL28 had, and list some proteins which have the same functions with MRPL28. You can find most of the proteins on our site.

Function	Related Protein
poly(A) RNA binding	SRSF7;FAM98A;TFB1M;HNRNPA0;C2orf15;RPF2;APOBEC3C;GTPBP10;IFI203
protein binding	HECTD3;RAB18;ARSI;STAT6;BAP1;SFTPC;ODF1;PPP2R3A;ARL8A
structural constituent of ribosome	RPL36AL;RPL32;MRPL9;MRPS9;RPL19;RPL10A;MRPS12;MRPS24;RPL5

MRPL28 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL28 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL28.

TRAF3IP2; CDR2; TEF; HMBOX1; FAM9B; BANP; TRAF4

Research Area

Yang, YR; Jian, W; et al. Characterization of TsMRP-L28, a mitochondrial ribosomal protein L28 from the parasitic nematode Trichinella spiralis. GENE 512:496-504(2013).

Wierschke, S; Gigout, S; et al. Evaluating reference genes to normalize gene expression in human epileptogenic brain tissues. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 403:385-390(2010).