MRPL28

  • Official Full Name

    mitochondrial ribosomal protein L28

  • Overview

    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion.
  • Synonyms

    MRPL28; mitochondrial ribosomal protein L28; MAAT1, melanoma associated antigen recognised by cytotoxic T lymphocytes; 39S ribosomal protein L28, mitochondrial; p15; 39S ribosomal protein L28 mitochondrial; 39S ribosomal protein L28 mitochondrial precursor; HGNC6756; L28mt; MAAT 1; MAAT1; Melanoma antigen p15; Melanoma associated antigen recognised by cytotoxic T lymphocytes; Melanoma associated antigen recognized by T lymphocytes; MGC8499; MRP L28; MRPL 28; MRP-L28; melanoma-associated antigen recognized by T lymphocytes; melanoma-associated antigen recognised by cytotoxic T lymphocytes;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MRPL28-3024H Recombinant Human Mitochondrial Ribosomal Protein L28, T7-tagged E.coli T7
Human MRPL28-363H Recombinant Human mitochondrial ribosomal protein L28, His-tagged E.coli His
Human MRPL28-4182HCL Recombinant Human MRPL28 293 Cell Lysate HEK293 N/A
Human MRPL28-5571H Recombinant Human MRPL28 Protein, GST-tagged Wheat Germ GST
Human MRPL28-4415H Recombinant Human MRPL28 protein, GST-tagged E.coli GST 1-256aa
Human MRPL28-6435HF Recombinant Full Length Human MRPL28 Protein, GST-tagged In Vitro Cell Free System GST 256 amino acids
Human MRPL28-5258H Recombinant Human MRPL28 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse MRPL28-10057M Recombinant Mouse MRPL28 Protein Mammalian Cell His
Mouse MRPL28-5693M Recombinant Mouse MRPL28 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MRPL28-5693M-B Recombinant Mouse MRPL28 Protein Pre-coupled Magnetic Beads HEK293
Mouse Mrpl28-4151M Recombinant Mouse Mrpl28 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish MRPL28-3004Z Recombinant Zebrafish MRPL28 Mammalian Cell His
Chicken MRPL28-3012C Recombinant Chicken MRPL28 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MRPL28 involved in several pathways and played different roles in them. We selected most pathways MRPL28 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL28 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Mitochondrial translationMRPL10;ICT1;MRPL54;MTFMT;MRPL39;MRPL28;MRPL3;TSFM;GFM1
Mitochondrial translation elongationMRPL48;MRPS31;MRPL44;MRPS35;MRPS30;MRPL47;MRPS24;MRPL49;MRPL46
Mitochondrial translation initiationMRPS31;MTFMT;MRPL38;MRPS24;ICT1;MRPS23;MRPL37;MRPS25;MRPL44
Mitochondrial translation terminationMRPS24;PTCD3;MRPL47;MRPS22;MRPL46;MRPL41;GFM2;MRPS33;GADD45GIP1
Organelle biogenesis and maintenanceCNGA5;IFT52;IFT-20;CYS1;TSFM;MRPL45;NPHP3;GFM2;BBS4
RibosomeRPS29;RPL29;RPS27L;RPS27.1;MRPS5;RPS3;RPS15A;RPL3L;RPL34-PS1

MRPL28 has several biochemical functions, for example, poly(A) RNA binding, protein binding, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL28 itself. We selected most functions MRPL28 had, and list some proteins which have the same functions with MRPL28. You can find most of the proteins on our site.

Function Related Protein
poly(A) RNA bindingMRPS14;IGF2BP3;MYH9;HNRNPA2B1;IFI16;CEBPZ;AATF;RPSA;HIST4H4
protein bindingHACE1;GSDMA2;ASAP2;CASP9;THEMIS;CCDC28B;LOR;MYO18A;MAF
structural constituent of ribosomeRPS9;RPL13A;RPS27A;RPS24;RPL19;RPS5;NDUFA7;RPS18;MRPS9

MRPL28 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL28 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL28.

TRAF3IP2; CDR2; TEF; HMBOX1; FAM9B; BANP; TRAF4

Research Area

Related articles

Yang, YR; Jian, W; et al. Characterization of TsMRP-L28, a mitochondrial ribosomal protein L28 from the parasitic nematode Trichinella spiralis. GENE 512:496-504(2013).
Wierschke, S; Gigout, S; et al. Evaluating reference genes to normalize gene expression in human epileptogenic brain tissues. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 403:385-390(2010).
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