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Official Full Name mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
Background The MSH2 gene is one of at least 4 genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma,While germline MSH2 mutations are responsible for approximately 50% of inherited, non-polyposis colorectal carcinoma (HNPCC). MSH2 encodes a protein of 934 amino acids.
Synonyms MSH2; mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli); COCA1, mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1); DNA mismatch repair protein Msh2; HNPCC; HNPCC1; hMSH2; FCC1; COCA1; LCFS2
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Msh2-4186M Recombinant Mouse Msh2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human MSH2-162H Recombinant Human MSH2 E.coli N/A
    Human MSH2-28175TH Recombinant Human MSH2 protein, GST-tagged Wheat Germ GST
    Human MSH2-28793TH Recombinant Human MSH2 Wheat Germ N/A
    Human MSH2-4120HCL Recombinant Human MSH2 293 Cell Lysate HEK293 N/A
    Human MSH2-493H Recombinant Human MSH2 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MSH2-621H Recombinant Human MSH2 Protein, His&GST-tagged Insect Cell His/GST
    Mouse MSH2-10131M Recombinant Mouse MSH2 Protein Mammalian Cell His
    Rat MSH2-3787R Recombinant Rat MSH2 Protein Mammalian Cell His
    Zebrafish MSH2-12683Z Recombinant Zebrafish MSH2 Mammalian Cell His

    msh2 involved in several pathways and played different roles in them. We selected most pathways msh2 participated on our site, such as Mismatch repair, Pathways in cancer, Colorectal cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with msh2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mismatch repair RFC5; PMS2; LIG1; RPA2; RPA4; RFC2; MSH2; RPA3; RFC3; RPA1
    Pathways in cancer VHL; LAMA5; CDH1; LAMA4; BMP4; MET; FZD5; RAC3; MSH3; MAP2K1
    Colorectal cancer PIK3R1; RHOA; TGFBR2; MAPK8; FOS; SMAD2; PIK3CD; PIK3R2; MSH3; MSH2

    msh2 has several biochemical functions, for example, contributes_to ADP binding, contributes_to ATP binding, contributes_to ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by msh2 itself. We selected most functions msh2 had, and list some proteins which have the same functions with msh2. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to ADP binding MSH2; ATP5D; MSH6
    contributes_to ATP binding MSH2; ATP5D; MSH6; SFRP5; ABCG8; ATP1A2; ATP1B1
    contributes_to ATPase activity ATP5L; RFC3; ATP5C1; ATP5D; ATP5F1; ATP5J2; ATP5H; ATP5A1; ABCG8; ATP1B1
    DNA binding MBD1B; RAG1; GPBP1; ZNF576.2; ELF2B; PPP1R10; ZNF789; SIX3A; POT1A; ZFP689
    DNA-dependent ATPase activity MSH3; DDX11; RAD51C; RAD51L3; SMARCA2; XRCC3; ERCC6; RAD51L1; RAD51D; DMC1
    contributes_to MutLalpha complex binding MSH6; MSH2
    Y-form DNA binding WRN; MEN1; MSH3; MSH2; RAD18
    centromeric DNA binding MSH3; KIF2C; ZW10; MSH2; CENPB; CENPC1; MLH3
    contributes_to dinucleotide insertion or deletion binding MSH3; MSH2
    contributes_to dinucleotide repeat insertion binding MSH2; MSH3
    double-strand/single-strand DNA junction binding MSH3; MSH2
    contributes_to double-stranded DNA binding MSH6; APITD1; MSH2; STRA13
    enzyme binding DDX5; PEX7; SUDS3; IQCB1; NKX2-1; PRMT1; CDK19; PLAUR; UBE4B; PTPN1
    contributes_to four-way junction DNA binding RAD51B; RAD51D; MSH2; RAD51L1; XRCC2; RAD51L3; MSH6; XRCC3; RAD51C
    contributes_to guanine/thymine mispair binding MSH2; MSH6
    guanine/thymine mispair binding MSH2
    heteroduplex DNA loop binding MSH2; MSH3
    contributes_to magnesium ion binding MSH6; MSH2
    contributes_to mismatched DNA binding MSH2; MSH3; MSH6
    contributes_to oxidized purine DNA binding MSH2; MSH6
    protein C-terminus binding AP2A1; ARL6IP5; SIRT1; SCLT1; YWHAQ; VPS36; TFCP2; MPDZ; PPP1R9B; HPCAL4
    protein binding KRT4; H2AFZ; ACTL8; KLK6; WEE1; PRDM14; PPM1G; FXYD6; NDE1; P4HA2
    contributes_to protein binding TAF10; CPSF3L; PAK1; ACVR2A; MSH2; POLR2A; MLH1; CRY1A; TGFBR3; INTS10
    protein homodimerization activity HNF1B; PCYT1A; FGFR1OP; CHMP3; CHEK2; USF2; TCF4; GSTZ1; NTRK1; RENBP
    protein kinase binding MAML1; NR4A3; TEX14; KCNA5; PRDX3; PRKAG3; SPDYE2; PDGFRB; MAPK6; EPHA1
    contributes_to single guanine insertion binding MSH3; MSH2; MSH6
    contributes_to single thymine insertion binding MSH6; MSH2
    contributes_to single-stranded DNA binding MSH2; IGJ; MLH1; POLR2D; MSH3; IGHM; PMS2

    msh2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with msh2 here. Most of them are supplied by our site. Hope this information will be useful for your research of msh2.

    MSH6; SLX4; EXO1; E2F3; BRCA1

    Stark, AM; Doukas, A; et al. Expression of DNA mismatch repair proteins MLH1, MSH2, and MSH6 in recurrent glioblastoma. NEUROLOGICAL RESEARCH 37:95-105(2015).
    Jentzsch, T; Robl, B; et al. Expression of MSH2 and MSH6 on a Tissue Microarray in Patients with Osteosarcoma. ANTICANCER RESEARCH 34:6961-6972(2014).

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