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MYB

Official Full Name

v-myb myeloblastosis viral oncogene homolog (avian)
Overview

This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants.
Synonyms

MYB; v-myb myeloblastosis viral oncogene homolog (avian); v myb avian myeloblastosis viral oncogene homolog; transcriptional activator Myb; c myb; c-myb8B_CDS; c-myb10A_CDS; c-myb13A_CDS; c-myb14A_CDS; proto-oncogene c-Myb; c-myb protein (140 AA); efg; Cm;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MYB-28009TH	Recombinant Human MYB	Wheat Germ	Non	640 amino acids	Inquiry
Human	MYB-1443H	Recombinant Human MYB protein, His & T7-tagged	E.coli	His&T7	Thr305~Gln558	Inquiry
Human	MYB-4045HCL	Recombinant Human MYB 293 Cell Lysate	HEK293	Non		Inquiry
Human	MYB-322HF	Recombinant Full Length Human MYB Protein	In Vitro Cell Free System		640 amino acids	Inquiry
Human	MYB-6649HF	Recombinant Full Length Human MYB Protein, GST-tagged	In Vitro Cell Free System	GST	640 amino acids	Inquiry
Human	MYB-5777H	Recombinant Human MYB Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MYB-4635H	Recombinant Human MYB Protein (Thr305-Gln558), N-His tagged	E.coli	His	Thr305-Gln558	Inquiry
Mouse	MYB-10279M	Recombinant Mouse MYB Protein	Mammalian Cell	His		Inquiry
Mouse	Myb-1444M	Recombinant Mouse Myb protein, His & T7-tagged	E.coli	His&T7	Lys35~Lys291	Inquiry
Mouse	MYB-5827M	Recombinant Mouse MYB Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	MYB-5827M-B	Recombinant Mouse MYB Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	MYB-6858C	Recombinant Chicken MYB	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

MYB involved in several pathways and played different roles in them. We selected most pathways MYB participated on our site, such as C-MYB transcription factor network, Factors involved in megakaryocyte development and platelet production, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
C-MYB transcription factor network	CEBPB;PIAS3;PPID;CBX4;SKI;PTCRA;CSF1R;TOM1;LECT2
Factors involved in megakaryocyte development and platelet production	MFN2;NFE2;DOCK9;MAFGB;HBBE2;SH2B3;VPS45;BA2;HMG20B
HTLV-I infection	IL6;PIK3R5;AKT1;STAT5A;CDC20;POLB;WNT4;HLA-DQB1;SMAD4
Hemostasis	SIRPA;ABHD12;BRPF3;MFN2;HBBE2;SH2B3;SERPINB8;CD9A;SLC7A6
IL2 signaling events mediated by PI3K
IL4-mediated signaling events	PARP14;EGR2;DOK2;MYBL1;CCL26;IRF4;RETNLB;IgG3;MYB
Neural Crest Differentiation	TFAP2A;TBX6;ZIC1;DLX5;LHX2;DLL3;MBP;HEY2;MYB
Notch-mediated HES/HEY network	TLE1;MYOD1;MYB;GATA1;ASCL1;CTBP1;YY1;HES6;GATA6

MYB has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, WD40-repeat domain binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYB itself. We selected most functions MYB had, and list some proteins which have the same functions with MYB. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA binding	NACC2;HLTF;OTX1;ZNF114;POU2F3;MED8;ZNF486;SPI1;FUBP3
WD40-repeat domain binding	USP47;MYB;CDC5L
protein binding	PACS1;AZI2;RPLP0;NVL;TMEM242;CRABP2;SNF8;NOTCH3;IFT27
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	SOX12;NR1H4;E2F4;PAX8;TFAM;NFIB;OTX2;CREB3L2;STAT3

MYB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYB here. Most of them are supplied by our site. Hope this information will be useful for your research of MYB.

SUMO2; SUMO1; ERC2; CLTC; KIF2A; PCDH17; SETD1A; NCAM2; ZFC3H1; NCOR1; PTMS

Research Area

Oncoprotein-Transcription Factors

Epithelial Stem Cell Transcription Factors

Hematopoietic Stem Cell Markers

Transcription Factors in the Akt Pathway

Hematopoietic Stem Cell Transcription Factors and Regulators

Wang, Z; Fan, C; et al. S5a binds to death receptor-6 to induce THP-1 monocytes to differentiate through the activation of the NF-kappa B pathway. JOURNAL OF CELL SCIENCE 127:3257-3268(2014).

Afroze, T; Yang, G; et al. Calcium Efflux Activity of Plasma Membrane Ca2+ ATPase-4 (PMCA4) Mediates Cell Cycle Progression in Vascular Smooth Muscle Cells. JOURNAL OF BIOLOGICAL CHEMISTRY 289:7221-7231(2014).