Recombinant Human MYB

• Cat.No.: MYB-28009TH
• Product Overview: Recombinant full length Human c-Myb with an N terminal proprietary tag; predicted mwt: 96.47 kDa inclusive of tag.

Specification

• Description: This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants.
• Protein length: 640 amino acids
• Molecular Weight: 96.470kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGK TRWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQH RWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHK RLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQ ESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTV NNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPAAAAI QRHYNDEDPEKEKRIKELELLLMSTENELKGQQVLPTQNH TCSYPGWHSTTIADHTRPHGDSAPVSCLGEHHSTPSLPAD PGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFID SFLNTSSNHENSDLEMPSLTSTPLIGHKLTVTTPFHRDQT VKTQKENTVFRTPAIKRSILESSPRTPTPFKHALAAQEIK YGPLKMLPQTPSHLVEDLQDVIKQESDESGIVAEFQENGP PLLKKIKQEVESPTDKSGNFFCSHHWEGDSLNTQLFTQTS PVADAPNILTSSVLMAPASEDEDNVLKAFTVPKNRSLASP LQPCSSTWEPASCGKMEEQMTSSSQARKYVNAFSARTLVM
• Sequence Similarities: Contains 3 HTH myb-type DNA-binding domains.

Gene Information

• Gene Name: MYB v-myb myeloblastosis viral oncogene homolog (avian) [ Homo sapiens ]
• Official Symbol: MYB
• Synonyms: MYB; v-myb myeloblastosis viral oncogene homolog (avian); v myb avian myeloblastosis viral oncogene homolog; transcriptional activator Myb; c myb
• Gene ID: 4602
• mRNA Refseq: NM_001130172
• Protein Refseq: NP_001123644
• MIM: 189990
• Uniprot ID: P10242
• Chromosome Location: 6q22-q23
• Pathway: C-MYB transcription factor network, organism-specific biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Hemostasis, organism-specific biosystem
• Function: DNA binding; protein binding