NCF2

  • Official Full Name

    neutrophil cytosolic factor 2

  • Overview

    This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]
  • Synonyms

    NCF2; neutrophil cytosolic factor 2; NCF-2; NOXA2; P67PHOX; P67-PHOX; neutrophil cytosol factor 2; NADPH oxidase activator 2; 67 kDa neutrophil oxidase factor; neutrophil NADPH oxidase factor 2; chronic granulomatous disease, autosomal 2; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NCF2-329H Recombinant Human NCF2, Gly & Pro tagged Insect Cell His
Human NCF2-30174TH Recombinant Human NCF2 Wheat Germ N/A
Human NCF2-354H Recombinant Human NCF2, His-GST tagged Insect Cell His
Human NCF2-1209H Recombinant Human NCF2, His-tagged E.coli His
Human NCF2-400H Recombinant Human NCF2 Protein, His-tagged E.coli His
Human NCF2-001HCL Recombinant Human NCF2 cell lysate Insect Cell N/A
Human NCF2-005HCL Recombinant Human NCF2 cell lysate Insect Cell N/A
Human NCF2-1486H Recombinant Human NCF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NCF2-475H Recombinant Human NCF2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NCF2-573HFL Recombinant Full Length Human NCF2 Protein, C-Flag-tagged Mammalian cells Flag
Human NCF2-1856H Recombinant Human NCF2 protein, GST-tagged E.coli GST
Human NCF2-1486H-B Recombinant Human NCF2 Protein Pre-coupled Magnetic Beads HEK293
Human NCF2-4668H Recombinant Human NCF2 Protein (Lys355-Val526), His tagged E.coli His
Human NCF2-5891H Recombinant Human NCF2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NCF2-335HF Recombinant Full Length Human NCF2 Protein In Vitro Cell Free System
Human NCF2-1984H Recombinant Human NCF2 protein Insect Cells N/A
Human NCF2-3243H Recombinant Human NCF2 protein(Met1-Val526), His&GST-tagged Insect Cells N-His&GST
Mouse NCF2-10468M Recombinant Mouse NCF2 Protein Mammalian Cell His
Mouse Ncf2-4309M Recombinant Mouse Ncf2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NCF2-5938M Recombinant Mouse NCF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NCF2-5938M-B Recombinant Mouse NCF2 Protein Pre-coupled Magnetic Beads HEK293
Rat NCF2-3920R Recombinant Rat NCF2 Protein Mammalian Cell His
Rat NCF2-3578R-B Recombinant Rat NCF2 Protein Pre-coupled Magnetic Beads HEK293
Rat NCF2-3578R Recombinant Rat NCF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish NCF2-6182Z Recombinant Zebrafish NCF2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NCF2 Related Articles
  • NCF2 Related Research Area

NCF2 involved in several pathways and played different roles in them. We selected most pathways NCF2 participated on our site, such as Phagosome, Osteoclast differentiation, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeCTSSA;CALR3B;ATP6V1F;ITGB1A;ATP6V1E1;ITGA2;NCF4;C3A.1;NCF1
Osteoclast differentiationSTAT1;PIK3R5;TNF;MAPK13;AKT2;MAP2K1;CYBA;LILRA5;TNFRSF11A
Leukocyte transendothelial migrationPRKCA;JAM3;VAV1;MAPK12;ICAM1;CDC42;MYL5;ITGB2L;MSN
LeishmaniasisHLA-DMA;C3;TLR2;IL12A;STAT1;HLA-DQB1;NFKBIA;NOS2;FCGR2C

NCF2 has several biochemical functions, for example, Rac GTPase binding, electron carrier activity, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCF2 itself. We selected most functions NCF2 had, and list some proteins which have the same functions with NCF2. You can find most of the proteins on our site.

Function Related Protein
Rac GTPase bindingDVL1;PAK7;PAK1;RAB7;SRGAP2A;RCC2;NOXA1;PAK3;PAK2A
electron carrier activityPRKRA;HSD17B6;ACADSB;AKR1A1;IDO1;CYP19A1;ETFDH;HAAO;ME2
protein C-terminus bindingDYNLL1;VPS4A;GRIP1;TOP2B;ERCC3;ERBB2;MAP3K7;PDZD3;PQBP1
protein bindingTAB1;PPARD;NCAPH;PIGK;CCR3;C1QL1;TTN;TOR1AIP2;C1QTNF2

NCF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCF2.

NCF1; NCF4; CDC42

Davis, NA; Lareau, CA; et al. Encore: Genetic Association Interaction Network Centrality Pipeline and Application to SLE Exome Data. GENETIC EPIDEMIOLOGY 37:614-621(2013).
Savchenko, VL; et al. Regulation of NADPH Oxidase Gene Expression with PKA and Cytokine IL-4 in Neurons and Microglia. NEUROTOXICITY RESEARCH 23:201-213(2013).
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