Recombinant Full Length Human NCF2 Protein, C-Flag-tagged

• Cat.No.: NCF2-573HFL
• Product Overview: Recombinant Full Length Human NCF2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 59.6 kDa
• AA Sequence: MSLVEAISLWNEGVLAADKKDWKGA LDAFSAVQDPHSRICFNIGCMYTIL KNMTEAEKAFTRSINRDKHL AVAYFQRGMLYYQTEKYDLAIKDLK EALIQLRGNQLIDYKILGLQFKLFA CEVLYNIAFMYAKKEEWKKA EEQLALATSMKSEPRHSKIDKAMEC VWKQKLYEPVVIPVGRLFRPNERQV AQLAKKDYLGKATVVASVVD QDSFSGFAPLQPQAAEPPPRPKTPE IFRALEGEAHRVLFGFVPETKEELQ VMPGNIVFVLKKGNDNWATV MFNGQKGLVPCNYLEPVELRIHPQQ QPQEESSPQSDIPAPPSSKAPGRPQ LSPGQKQKEEPKEVKLSVPM PYTLKVHYKYTVVMKTQPGLPYSQV RDMVSKKLELRLEQTKLSYRPRDSN ELVPLSEDSMKDAWGQVKNY CLTLWCENTVGDQGFPDEPKESEKA DANNQTTEPQLKKGSQVEALFSYEA TQPEDLEFQEGDIILVLSKV
  NEEWLEGECKGKVGIFPKVFVEDCA TTDLESTRREVTRTRPLEQKLISEE DLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Leukocyte transendothelial migration

Gene Information

• Gene Name: NCF2 neutrophil cytosolic factor 2 [ Homo sapiens (human) ]
• Official Symbol: NCF2
• Synonyms: NCF-2; NOXA2; P67PHOX; P67-PHOX
• Gene ID: 4688
• mRNA Refseq: NM_001127651.3
• Protein Refseq: NP_001121123.1
• MIM: 608515
• UniProt ID: P19878