NDUFA2
-
Official Full Name
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
-
Overview
The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants. -
Synonyms
NDUFA2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2 (8kD, B8); NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; B8; complex I B8 subunit; CD 14; CD14; CI B8; Complex I B8; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2 8kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2; NADH ubiquinone oxidoreductase B8 subunit; NDUFA 2; OTTHUMP00000159890; OTTHUMP00000223709; NADH-ubiquinone oxidoreductase subunit CI-B8; CIB8;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- NDUFA2 Related Articles
NDUFA2 involved in several pathways and played different roles in them. We selected most pathways NDUFA2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | ATP6V1G1;ATP5G1;NDUFS8;COX7A2;ATP5S;NDUFA1;COX10;ATP4B;NDUFA12 |
| Metabolic pathways | B3GAT3;CYP4F14;ACAA1A;ATP6V0C;DHRS13L1;MIBP2;PIP5KL1;PLCD1A;PTGES3B |
| Non-alcoholic fatty liver disease (NAFLD) | LEPR;PRKAG2;PPARA;INSR;ADIPOQ;NDUFC2-KCTD14;IL1A;PIK3R1;Il6ra |
| Alzheimers disease | LRP1;UQCR10;COX6B2;CASP8;GAPDH;NDUFB11;NDUFS7;NDUFA11;PLCB2 |
| Parkinsons disease | Atp5g2;ATP5G3;VDAC3;NDUFB7;GNAL;NDUFS7;NDUFB1;UQCRH;APAF1 |
| Huntingtons disease | NDUFB3;VDAC3;CREB3L1;POLR2J3;DCTN1;DNAH14;ATP5G1;DNALI1;Atp5g2 |
NDUFA2 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFA2 itself. We selected most functions NDUFA2 had, and list some proteins which have the same functions with NDUFA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADH dehydrogenase (ubiquinone) activity | NDUFS3;NDUFS2;NDUFC2;NDUFA5;NDUFA4;NDUFA1;NDUFB9;NDUFC2-KCTD14;NDUFS5 |
NDUFA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFA2.
NDUFS4; NDUFS5; NDUFS3; NDUFV1; NDUFA6; NDUFA9; NDUFA11
- Q&As
- Reviews
Ask a Question for All NDUFA2 Products
Required fields are marked with *
My Review for All NDUFA2 Products
Required fields are marked with *
