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NEK1

Official Full Name

NIMA (never in mitosis gene a)-related kinase 1
Overview

The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene.
Synonyms

NEK1; NIMA (never in mitosis gene a)-related kinase 1; serine/threonine-protein kinase Nek1; KIAA1901; NY REN 55; nimA-related protein kinase 1; protein-serine/threonine kinase; renal carcinoma antigen NY-REN-55; never in mitosis A-related kinase 1; SRPS2;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Human
Mouse

Source

E.coli
HEK293
Insect cell
Mammalian Cell
Sf21
Sf9 Insect Cell
Wheat Germ

Tag

GST
GST,His
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NEK1-171H	Active Recombinant Human NEK1(1-505) Protein, N-GST,C-His-tagged	Sf21	GST,His	1-505 aa	Inquiry
Human	NEK1-705H	Recombinant Human NEK1	Mammalian Cell	His		Inquiry
Human	NEK1-29277TH	Recombinant Human NEK1	Wheat Germ	N/A	100 amino acids	Inquiry
Human	NEK1-2993H	Active Recombinant Human NEK1 Protein, GST-tagged	Insect cell	GST	1-505	Inquiry
Human	NEK1-301539H	Recombinant Human NEK1 protein, GST-tagged	E.coli	GST	Lys557-Asp740	Inquiry
Human	NEK1-3610H-B	Recombinant Human NEK1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	NEK1-9928H	Active Recombinant Human NEK1 Protein, GST-tagged	Insect cell	GST	1-477	Inquiry
Human	NEK1-3124H	Recombinant Human NEK1 protein, His-tagged	E.coli	His	557-740 aa	$319 / 25ug
Human	NEK1-3610H	Recombinant Human NEK1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	NEK1-1437M	Active Recombinant Mouse NEK1, GST-tagged	Sf9 Insect Cell	GST	1-495 aa	Inquiry
Mouse	Nek1-2039M	Recombinant Mouse Nek1 Protein, GST-tagged	Insect cell	GST	1-495	Inquiry

Involved Pathway
Protein Function
Interacting Protein

NEK1 involved in several pathways and played different roles in them. We selected most pathways NEK1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NEK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

NEK1 has several biochemical functions, for example, ATP binding, kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEK1 itself. We selected most functions NEK1 had, and list some proteins which have the same functions with NEK1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	WARS;TTLL11;ACSM2;UPF1;GRK7;NIM1K;ATP6V1AA;DHX15;TWF1
kinase activity	HYKK.2;CAMK1GA;STK38A;NEK5;PANK1A;SMG1;MAP2K2A;MKNK2A;RPS6KAL
metal ion binding	TATDN3;ZSCAN5A;CEPT1;COL9A1;MMP30;BMP1B;STK24;ATP1A3A;TET3
protein binding	MUM1;PTCH1;SIX4;PRMT6;ACYP2;TDRD1;NLRP12;POP4;HIP1
protein kinase activity	GC2;TAOK1;KALRN;EIF2AK3;MAPK8B;LTK;TRIM24;CCL2;GRK1A
protein serine/threonine kinase activity	PAK1;MAP2K1;TSSK6;PRKACBA;MAPKAPK5;SNRK;MINK1;MTOR;NUAK1
protein tyrosine kinase activity	SRC;TNK2B;BAZ1B;NTRK3A;ERBB3B;FGFR1;TNK1;DSTYK;ZNF143B

NEK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEK1.

LRRK2; FEZ1; FEZ2; saicar; PKM; LRRK1; ATRX; TSC2; MRE11A; YWHAH; TP53BP1; PPP2R5D; ZNF350; EXOSC4