NEK6
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Official Full Name
NIMA (never in mitosis gene a)-related expressed kinase 6
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Overview
The Aspergillus nidulans never in mitosis A (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform f -
Synonyms
NEK6; NIMA (never in mitosis gene a)-related expressed kinase 6; serine/threonine-protein kinase Nek6; Highly similar to cell cycle protein kinase CDC5/MSD2; NEK6_HUMAN; Never in mitosis A-related kinase 6; NIMA (Never In Mitosis Gene A) Related Kinase 6; NimA related protein kinase 6; NimA-related protein kinase 6; Protein kinase SID6 1512; Protein kinase SID6-1512; Putative serine threonine protein kinase; Serine/threonine protein kinase Nek6; SID6 1512; SID61512; NIMA-related expressed kinase 6; 1300007C09Rik;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Sf21
- Sf9 Insect Cell
- GST
- His
- Myc
- DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
NEK6 involved in several pathways and played different roles in them. We selected most pathways NEK6 participated on our site, such as Activation of NIMA Kinases NEK9, NEK6, NEK7, Cell Cycle, Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of NIMA Kinases NEK9, NEK6, NEK7 | NEK7;NEK6;NEK9 |
| Cell Cycle | TSGA14;E2F3;CDC14B;SGOL2;AURKB;CENPC1;VRK2;SFN;DYNC1I2 |
| Cell Cycle, Mitotic | CEP72;B9D2;CTDNEP1B;LMNB1;DNA2;NCAPH;CDKN2D;RANGAP1B;CEP78 |
| M Phase | ENSA;ERCC6L;NDEL1;NEK7;KNTC1;CENPE;B9D2;CCDC99;DSN1 |
| Mitotic Prophase | NEK6;NCAPD3;VRK2;ENSA;SET;ARPP19;MCPH1;ENSAA;SMC4 |
| Nuclear Envelope Breakdown | CTDNEP1;DULLARD;CNEP1R1;CTDNEP1B;TMEM188;NEK6;NEK7;CTDNEP1A;NEK9 |
| Nuclear Pore Complex (NPC) Disassembly | NEK7;NEK6;NEK9 |
NEK6 has several biochemical functions, for example, ATP binding, kinesin binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEK6 itself. We selected most functions NEK6 had, and list some proteins which have the same functions with NEK6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CSNK1G2A;PBK;TTK;CHKB;SEPHS1;NLRP7;EGFR;RUNX3;PRKCB |
| kinesin binding | KIAA1279;MAPK8IP3;PIFO;KIF18B;KIFAP3B;MAPK8IP2;TOR1A;DISC1;KCNC1 |
| magnesium ion binding | PTENB;PPM1NB;SRPK1;SIK3;FAN1;TREX2;RRAGC;HPGDS;MTPAP |
| protein binding | SART1;CCER1;RARRES3;AXIN1;TNK2;TTF2;ATP10A;NEFM;GBF1 |
| protein kinase binding | NCS1;NR4A3;CCNT2A;KIF13B;PPME1;IL12RB2;HNRNPA0;SPDYB;THY1 |
| protein serine/threonine kinase activity | RPS6KB2;CAMK1GB;SRPK1A;ULK4;MAP3K14;CAMK2G1;LATS1;NEK9;TNIK |
| signal transducer activity | GNG13A;TRADD;IRS1;IL1R1;CREBBP;OLFR491;TAAR8B;Sectm1a;STAT4 |
NEK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEK6.
NECAB2; TRIM27; TCF4; TRIM23; XIAP; TNK2; AES
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