NODAL

Official Full Name

nodal growth differentiation factor
Overview

The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development. [provided by RefSeq, Jul 2008]
Synonyms

NODAL; nodal growth differentiation factor; HTX5; nodal homolog;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E. coli
E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

C
His
Flag
GST
Fc
Avi
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NODAL-30H	Active Recombinant Human Nodal Protein,Tag Free	E. coli	Non	238-347 aa	Inquiry
Human	NODAL-30448TH	Recombinant Human NODAL	Wheat Germ	Non	72 amino acids	Inquiry
Human	NODAL-528H	Recombinant Human NODAL	Mammalian Cell	His	245-354a.a.	Inquiry
Human	NODAL-3771HCL	Recombinant Human NODAL 293 Cell Lysate	HEK293	Flag	1-347a.a.	Inquiry
Human	NODAL-5964H	Recombinant Human NODAL Protein, GST-tagged	Wheat Germ	GST	1-326a.a.	Inquiry
Human	NODAL-3648H	Recombinant Human NODAL Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	NODAL-2494H	Recombinant Human NODAL Protein, His-tagged	E.coli	His	Ala27-Leu347	Inquiry
Human	NODAL-6680HF	Recombinant Full Length Human NODAL Protein, GST-tagged	In Vitro Cell Free System	GST	326 amino acids	Inquiry
Human	NODAL-2913H	Recombinant Human NODAL protein, His-tagged	E.coli	His	40-338 aa	$319 / 25μg
Human	NODAL-31H	Recombinant Human NODAL Protein, His-tagged	E. coli	C-His	238-347 aa	Inquiry
Human	NODAL-3648H-B	Recombinant Human NODAL Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	NODAL-0528H	Recombinant Human NODAL protein, GST-tagged	E.coli	GST	His238-Leu347	Inquiry
Human	NODAL-235H	Active Recombinant Human NODAL Protein (His238-Leu347), C-His tagged, Animal-free, Carrier-free	E.coli	His	His238-Leu347	Inquiry
Mouse	NODAL-28M	Recombinant Mouse Nodal	E.coli	Non		Inquiry
Mouse	NODAL-0527M	Recombinant Mouse NODAL protein, GST-tagged	E.coli	GST	His245-Leu354	Inquiry
Mouse	NODAL-29M	Recombinant Mouse NODAL Protein, His-tagged	E.coli	His	His245~Leu354	Inquiry
Mouse	Nodal-1833M	Recombinant Mouse Nodal Protein, His-tagged	E.coli	His	His245-Leu354	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

NODAL involved in several pathways and played different roles in them. We selected most pathways NODAL participated on our site, such as TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with NODAL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
TGF-beta signaling pathway	SKP1;SMURF2;ACVR2B;AMH;BMP4;SPAW;TNF;TGFBR1;BMP2
Signaling pathways regulating pluripotency of stem cells	KLF4;BMPR1A;WNT11;ID2;APC;MAPK12;IGF1R;FGF2;LEFTY2

NODAL has several biochemical functions, for example, cytokine activity, growth factor activity, morphogen activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NODAL itself. We selected most functions NODAL had, and list some proteins which have the same functions with NODAL. You can find most of the proteins on our site.

Function	Related Protein
cytokine activity	IL37;IFNG;IL12BA;MSTNA;LFT1;CMTM6;GM13279;IL36RN;HMGB1B
growth factor activity	WISP3;HBEGFA;INHBE;EPGN;TGFB1A;THBS4;Fgf15;FGF20A;FGF22
morphogen activity	GREM1;DAND5;NBL1;CER1;Shh;NODAL
receptor agonist activity	WNT1;NODAL;SFRP2;WNT3A;WNT7A;WNT4;WNT8A;GAS6;GREM1
transforming growth factor beta receptor binding	SMAD2;MSTNB;SPAW;TGFB1A;BMP8B;BMP6;GDF7;LRG1;GDF9
type I activin receptor binding	NDR2;SPAW;SMAD6;NDR1;NODAL

NODAL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NODAL here. Most of them are supplied by our site. Hope this information will be useful for your research of NODAL.

Research Area

Early Mesodermal Lineage Markers

Other Cytokines & Receptors

Ectodermal Lineage Markers

Mesodermal Lineage Markers

Cardona, C; Sanchez-Mejias, E; et al. Expression of Gls and Gls2 Glutaminase Isoforms in Astrocytes. GLIA 63:365-382(2015).

Rutgen, BC; Gerner, W; et al. Exploratory assessment of CD4(+) T lymphocytes in brown hares (Lepus europeus) using a cross-reactive anti-rabbit CD4 antibody. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 161:108-115(2014).