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NR0B2

Official Full Name

nuclear receptor subfamily 0, group B, member 2
Overview

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Synonyms

NR0B2; nuclear receptor subfamily 0, group B, member 2; nuclear receptor subfamily 0 group B member 2; SHP; nuclear receptor SHP; small heterodimer partner; orphan nuclear receptor SHP; SHP1; FLJ17090;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rat

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NR0B2-638H	Recombinant Human NR0B2 Protein, His-tagged	E.coli	His		Inquiry
Human	NR0B2-3722HCL	Recombinant Human NR0B2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NR0B2-473H	Recombinant Human NR0B2 Protein, His-tagged	E.coli	His	Met1~Arg257	Inquiry
Human	NR0B2-6690HF	Recombinant Full Length Human NR0B2 Protein, GST-tagged	In Vitro Cell Free System	GST	257 amino acids	Inquiry
Human	NR0B2-3606H	Recombinant Human NR0B2 Protein (Met1-Arg257), His tagged	E.coli	His	Met1-Arg257	Inquiry
Human	NR0B2-6066H	Recombinant Human NR0B2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Rat	NR0B2-4061R	Recombinant Rat NR0B2 Protein	Mammalian Cell	His		Inquiry
Rat	NR0B2-3720R	Recombinant Rat NR0B2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	Nr0b2-474R	Recombinant Rat Nr0b2 Protein, His-tagged	E.coli	His	Met1~Arg260	Inquiry
Rat	NR0B2-3720R-B	Recombinant Rat NR0B2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	NR0B2-2582C	Recombinant Chicken NR0B2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
NR0B2 Related Articles
NR0B2 Related Research Area

NR0B2 involved in several pathways and played different roles in them. We selected most pathways NR0B2 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR0B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Bile secretion	ABCB1;ATP1A3;EPHX1;ATP1B3;BAAT;FAM84B;SCTR;ABCB11;SCARB1

NR0B2 has several biochemical functions, for example, DNA binding, peroxisome proliferator activated receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR0B2 itself. We selected most functions NR0B2 had, and list some proteins which have the same functions with NR0B2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	NEUROD4;ZFP518A;BHLHA15;MSGN1;H2AFY;GLIS2;ZBED6;SSH3;KIF22
peroxisome proliferator activated receptor binding	CREBBP;HMGA1-RS1;IKBKG;MED1;ASXL1;NFATC4;EP300;PPARGC1A;PRMT2
protein binding	INIP;NCAPD2;RB1CC1;RPF1;CT45A3;GMNN;PROL1;ICAM4;LRRC33
protein complex binding	CAPG;MLC1;ITPR1;WASF2;DAG1;MYO7A;VPS28;ABI1;ULK1
protein domain specific binding	STAMBP;TRP63;ST13;CENPJ;UNC13A;STX1A;ZBTB16;SHROOM2;CALM3
protein homodimerization activity	ANO2;PEX11A;BCL11A;SDCBP;GAMT;PTPRE;HES1;CEBPB;KCNE2
retinoid X receptor binding	NR1H4;FUS;VDR;NCOA1;HMGA1-RS1;MED25;NR0B2;NRIP1;HMGA1
steroid hormone receptor activity	RORAA;OR51E2;NR4A2;NR2F5;VDRA;NR6A1B;NR1D2A;NR1H2;PAQR7A
thyroid hormone receptor binding	MED12;FUS;NCOA3;NSD1;GAS2L1;MED13;NR0B2;PRMT2;MED1
transcription corepressor activity	KCNIP3;ZNF136;SMYD1;CTBP2A;SIRT6;BCOR;SKOR1A;GPS2;SKOR1
transcription factor binding	BRD7;TP53;SIRT1;MYBBP1A;GATA6;TLE1;NFKB1;C1QBP;GATA2

NR0B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR0B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR0B2.

SIRT1; TP53; MDM2; PLSCR1; ESRRG; Traf6; ZMYND10; FN1; HNRNPA1

Fujii, S; Nishikawa-Torikai, S; et al. Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells. SCIENTIFIC REPORTS 5:-(2015).

Nam, YS; Kim, Y; et al. Small Heterodimer Partner Blocks Cardiac Hypertrophy by Interfering With GATA6 Signaling. CIRCULATION RESEARCH 115:493-+(2014).

Repulsive Guidance Molecules and Receptors