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Official Full Name nuclear receptor subfamily 0, group B, member 2
Background The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Synonyms NR0B2; nuclear receptor subfamily 0, group B, member 2; nuclear receptor subfamily 0 group B member 2; SHP; nuclear receptor SHP; small heterodimer partner; orphan nuclear receptor SHP; SHP1; FLJ17090
    • Species :
    • Chicken
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NR0B2-3722HCL Recombinant Human NR0B2 293 Cell Lysate HEK293 N/A
    Human NR0B2-473H Recombinant Human NR0B2 Protein, His-tagged E.coli His
    Human NR0B2-6066H Recombinant Human NR0B2 Protein, GST-tagged Wheat Germ GST
    Human NR0B2-638H Recombinant Human NR0B2 Protein, His-tagged E.coli His
    Rat NR0B2-4061R Recombinant Rat NR0B2 Protein Mammalian Cell His
    Rat Nr0b2-474R Recombinant Rat Nr0b2 Protein, His-tagged E.coli His
    Chicken NR0B2-2582C Recombinant Chicken NR0B2 Mammalian Cell His

    nr0b2 involved in several pathways and played different roles in them. We selected most pathways nr0b2 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with nr0b2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Bile secretion CFTR; CYP7A1; SLC51A; ATP1A3; SCTR; ADCY3; SLC51B; FXYD2; SLCO1A2; ATP1B2

    nr0b2 has several biochemical functions, for example, DNA binding, peroxisome proliferator activated receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by nr0b2 itself. We selected most functions nr0b2 had, and list some proteins which have the same functions with nr0b2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding TAL2; SMUG1; ZNF521; MIER3; BHLHE41; POT1A; ZC3H3; FOXF2; IRX5A; FOXG1D
    peroxisome proliferator activated receptor binding ASXL1; HMGA1-RS1; NR0B2; PRMT2; ASXL2; MED1; IKBKG; HMGA1; CREBBP; EP300
    protein binding EHMT2; ACSF2; MXD3; JAM2; CAP2; CDC40; CYB5R2; NANOS3; NCOA3; GSK3B
    protein complex binding NDUFA8; CDK4; CCND1; NSF; GRIN2A; FGFR1; CD2AP; RXRA; PEX1; NASP
    protein domain specific binding TBL1X; MITD1; STMN3; DRD3; GABRR1; PLXND1; RAB27A; ARFIP2; YWHAQB; FOXH1
    protein homodimerization activity SP1; GM5506; DMRT2A; NR6A1B; NKX2-5; TIMM10; UXS1; ADH1; NADKD1; ABCB10
    retinoid X receptor binding PPARG; NRIP1; RARG; NSD1; VDR; HMGA1; NR1H2; HMGA1-RS1; NCOA1; MED25
    steroid hormone receptor activity NR2C2; RORCA; NR5A2; NR2F2; PAQR7; NR1H4; RARGA; NR6A1A; NR1D4B; NR2F1
    thyroid hormone receptor binding FUS; MED13; TRIP12; NCOR1; MED16; GTF2B; NR0B2; MED17; TAF7; MED12
    transcription corepressor activity SKOR1A; ZNF274; PROX1; LHX9; LIMD1; CDX2; SIAH2; MNT; NR2F2; ZHX1
    transcription factor binding NBN; HDAC5; HDAC2; SRF; PBX2; SLC26A5; ENPP2; TMEM173; FOXO1; NKX2

    nr0b2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with nr0b2 here. Most of them are supplied by our site. Hope this information will be useful for your research of nr0b2.

    SIRT1; TP53; MDM2; PLSCR1; ESRRG; Traf6; ZMYND10; FN1; HNRNPA1

    Fujii, S; Nishikawa-Torikai, S; et al. Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells. SCIENTIFIC REPORTS 5:-(2015).
    Nam, YS; Kim, Y; et al. Small Heterodimer Partner Blocks Cardiac Hypertrophy by Interfering With GATA6 Signaling. CIRCULATION RESEARCH 115:493-+(2014).

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