|Official Full Name||purinergic receptor P2X, ligand-gated ion channel, 3|
|Background||The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]|
|Synonyms||P2RX3; purinergic receptor P2X, ligand-gated ion channel, 3; P2X3; P2X purinoceptor 3; ATP receptor; purinoceptor P2X3; P2X receptor, subunit 3; purinergic receptor P2X3;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
P2RX3 involved in several pathways and played different roles in them. We selected most pathways P2RX3 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Calcium signaling pathway||PTGER3; CHRM2; ORAI3; PPP3R2; P2RX4; CACNA1H; CACNA1SA; ADORA2AA; P2RX3; NOS2|
|Neuroactive ligand-receptor interaction||GRM6A; GABRA2; DRD4-RS; TAAR1B; FSHB; PTH2R; GPR50; MCHR1; DRD4B; DRD2A|
P2RX3 has several biochemical functions, for example, ATP binding, extracellular ATP-gated cation channel activity, purinergic nucleotide receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX3 itself. We selected most functions P2RX3 had, and list some proteins which have the same functions with P2RX3. You can find most of the proteins on our site.
|ATP binding||CAMK2G1; UCK1; NDUFA13; XRCC6; DHX34; ATP2A2; CLCN6; ACVR2A; ATP1A1A.2; ATP2A1|
|extracellular ATP-gated cation channel activity||P2RX8; P2RX4B; P2RX3; P2RX3B; P2RX4; P2RX6; P2RX2; NNR; P2RX4A; P2RX1|
|purinergic nucleotide receptor activity||P2RX3A; NNR; P2RX4; P2RX3B; P2RX8; P2RX5; P2RX6; P2RX4A; P2RX2; P2RX4B|
P2RX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RX3.