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P2RX3

Official Full Name

purinergic receptor P2X, ligand-gated ion channel, 3
Overview

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]
Synonyms

P2RX3; purinergic receptor P2X, ligand-gated ion channel, 3; P2X3; P2X purinoceptor 3; ATP receptor; purinoceptor P2X3; P2X receptor, subunit 3; purinergic receptor P2X3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mamanlian cells
Mammalian Cell
Wheat Germ

Tag

Flag
GST
His
Fc
Avi
Myc
DDK
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	P2RX3-30538TH	Recombinant Human P2RX3	Wheat Germ	Non	110 amino acids	Inquiry
Human	P2RX3-9164H	Recombinant Human P2RX3, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Human	P2RX3-1491H	Recombinant Human P2RX3, GST-tagged	E.coli	GST	44-326aa	$319 / 25μg
Human	P2RX3-3500HCL	Recombinant Human P2RX3 293 Cell Lysate	HEK293	Non		Inquiry
Human	P2RX3-1492H	Recombinant Human P2RX3 protein, His-tagged	E.coli	His	44-326 aa	$319 / 25μg
Human	P2RX3-1741H	Recombinant Human P2RX3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Human	P2RX3-3902HFL	Recombinant Full Length Human P2RX3, Flag-tagged	Mamanlian cells	Flag		Inquiry
Mouse	P2RX3-12267M	Recombinant Mouse P2RX3 Protein	Mammalian Cell	His		Inquiry
Mouse	P2rx3-4636M	Recombinant Mouse P2rx3 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Mouse	P2RX3-6456M	Recombinant Mouse P2RX3 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	P2RX3-6456M-B	Recombinant Mouse P2RX3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

P2RX3 involved in several pathways and played different roles in them. We selected most pathways P2RX3 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcium signaling pathway	CCKBR;PPIFB;GNA11;PRKCB;PPP3CCB;TACR3;PLCD3;PPP3R2;PRKACBB
Neuroactive ligand-receptor interaction	GRM8;NPBWR1;ADORA2AA;GABRQ;KISS1R;PRLR;VIPR1B;FPR3;TAAR14D

P2RX3 has several biochemical functions, for example, ATP binding, extracellular ATP-gated cation channel activity, purinergic nucleotide receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX3 itself. We selected most functions P2RX3 had, and list some proteins which have the same functions with P2RX3. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	PFKMA;UBE2M;ABCC2;MYH7B;UBE2F;HELQ;CLPB;ABCB11;UHMK1
extracellular ATP-gated cation channel activity	P2RX2;P2RX4B;P2RX7;P2RX5;P2RX6;P2RX4;P2RX3;P2RX8;P2RX3B
purinergic nucleotide receptor activity	P2RX4B;P2RX7;P2RX3;P2RX1;P2RX4;P2RX5;P2RX4A;P2RX6;NNR

P2RX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RX3.