• Official Full Name

    purinergic receptor P2X, ligand-gated ion channel, 3

  • Background

    The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]
  • Synonyms

    P2RX3; purinergic receptor P2X, ligand-gated ion channel, 3; P2X3; P2X purinoceptor 3; ATP receptor; purinoceptor P2X3; P2X receptor, subunit 3; purinergic receptor P2X3;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mamanlian cells
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • His (Fc)
    • Avi
    • Myc
    • DDK
    • Myc|DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human P2RX3-1492H Recombinant Human P2RX3 protein, His-tagged E.coli His
    Human P2RX3-3500HCL Recombinant Human P2RX3 293 Cell Lysate HEK293 N/A
    Human P2RX3-30538TH Recombinant Human P2RX3 Wheat Germ N/A
    Human P2RX3-9164H Recombinant Human P2RX3, MYC/DDK-tagged HEK293 Myc/DDK
    Human P2RX3-3902HFL Recombinant Full Length Human P2RX3, Flag-tagged Mamanlian cells Flag
    Human P2RX3-1741H Recombinant Human P2RX3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human P2RX3-1491H Recombinant Human P2RX3, GST-tagged E.coli GST
    Mouse P2RX3-12267M Recombinant Mouse P2RX3 Protein Mammalian Cell His
    Mouse P2rx3-4636M Recombinant Mouse P2rx3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse P2RX3-6456M Recombinant Mouse P2RX3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse P2RX3-6456M-B Recombinant Mouse P2RX3 Protein Pre-coupled Magnetic Beads HEK293
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • P2RX3 Related Research Area

    P2RX3 involved in several pathways and played different roles in them. We selected most pathways P2RX3 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathwayTNNC1;NOS2B;ATP2A3;ADRB1;MYLK3;PLCB1;ADRB3B;GNA15;SLC8A1
    Neuroactive ligand-receptor interactionRXFP2;MCHR2;TAAR12E;GRIA2B;PTGER4C;PRP2;GRIK1;GLRBB;P2RX3A

    P2RX3 has several biochemical functions, for example, ATP binding, extracellular ATP-gated cation channel activity, purinergic nucleotide receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX3 itself. We selected most functions P2RX3 had, and list some proteins which have the same functions with P2RX3. You can find most of the proteins on our site.

    Function Related Protein
    extracellular ATP-gated cation channel activityP2RX3A;P2RX1;P2RX8;P2RX7;P2RX4;P2RX2;P2RX3B;P2RX5;NNR
    purinergic nucleotide receptor activityP2RX4B;P2RX3;NNR;P2RX8;P2RX7;P2RX4A;P2RX3B;P2RX2;P2RX4

    P2RX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RX3.

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