Recombinant Human P2RX3, MYC/DDK-tagged

• Cat.No.: P2RX3-9164H
• Product Overview: Recombinant human P2RX3 protein, fused to MYC/DDK-tag at C-terminus, was expressed in E.coli. Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.

Specification

• Description: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
• Source: Human 293HEK cells
• Species: Human
• Tag: Myc&DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 44.1kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Storage: Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3 [ Homo sapiens ]
• Official Symbol: P2RX3
• Synonyms: P2RX3; purinergic receptor P2X, ligand-gated ion channel, 3; P2X purinoceptor 3; P2X3; ATP receptor; purinoceptor P2X3; P2X receptor, subunit 3; purinergic receptor P2X3; MGC129956
• Gene ID: 5024
• mRNA Refseq: NM_002559
• Protein Refseq: NP_002550
• MIM: 600843
• UniProt ID: P56373
• Chromosome Location: 11q12
• Pathway: Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem
• Function: ATP binding; extracellular ATP-gated cation channel activity; extracellular ATP-gated cation channel activity; ion channel activity; purinergic nucleotide receptor activity; purinergic nucleotide receptor activity; receptor activity