P2RX4
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Official Full Name
purinergic receptor P2X, ligand-gated ion channel, 4
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Overview
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012] -
Synonyms
P2RX4; purinergic receptor P2X, ligand-gated ion channel, 4; P2X4; P2X4R; P2X purinoceptor 4; ATP receptor; purinoceptor P2X4; P2X receptor, subunit 4; purinergic receptor P2X4; ATP-gated cation channel protein;
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- Flag
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- Involved Pathway
- Protein Function
- Interacting Protein
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P2RX4 involved in several pathways and played different roles in them. We selected most pathways P2RX4 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | PRKCBB;PHKG1B;GRIN1B;CALM2A;CALM4;PRKCB;GNAQ;HTR2C;EDNRAA |
| Neuroactive ligand-receptor interaction | F2R;GRIK4;MLNR;P2RX3;TRHRB;P2RY13;P2RX4B;TACR3;TAAR12J |
P2RX4 has several biochemical functions, for example, ATP binding, cadherin binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX4 itself. We selected most functions P2RX4 had, and list some proteins which have the same functions with P2RX4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SMC1A;PANK3;GM711;SUCLG1;EIF4A3;BCR;TARS2;CAD;XRCC6 |
| cadherin binding | TBC1D2;PSEN1;CTNNA2;CTNNA1;CTNNAL1;OLFM4;NEO1;TRPC4;NUMB |
| copper ion binding | IL1A;APOA4;COMMD1;MOXD1;ATP7A;LOXL5A;S100A12;PRNP;TYRP1B |
| drug binding | HMGB2;PDE4C;TYMS;TLR8;MT3;PPP3CB;CYP2D6;DHFR;SRP54B |
| extracellular ATP-gated cation channel activity | P2RX4;P2RX4A;NNR;P2RX2;P2RX1;P2RX8;P2RX3;P2RX7;P2RX3B |
| protein binding | MAZ;S100A16;MAPK4;NOX1;CYP1A1;MID2;IGF2BP1;NPM1;CCNA2 |
| protein homodimerization activity | DMRT3A;SEPHS1;OLIG2;GJC3;XCL1;RNF17;QDPR;Defa-rs7;SLC26A5 |
| purinergic nucleotide receptor activity | P2RX6;P2RX4A;NNR;P2RX1;P2RX3B;P2RX2;P2RX4B;P2RX8;P2RX4 |
| receptor binding | CADM1;NRG1;HTT;DDX54;APOF;EHHADH;HCK;AGXT;ABL1 |
| zinc ion binding | TRIM35-31;ADH1;ABLIM1B;ZMYM5;NR5A1;ZDHHC16A;TRIM24;ZRANB3;JUB |
P2RX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RX4.
KRTAP5-9; NOTCH2NL; PIH1D3; MCM2; WNT4; opuD
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