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Official Full Name purinergic receptor P2X, ligand-gated ion channel, 4
Background The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
Synonyms P2RX4; purinergic receptor P2X, ligand-gated ion channel, 4; P2X4; P2X4R; P2X purinoceptor 4; ATP receptor; purinoceptor P2X4; P2X receptor, subunit 4; purinergic receptor P2X4; ATP-gated cation channel protein;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • HEK293T
    • in vitro E. coli
    • Mammalian Cell
    • Tag :
    • His
    • SUMO
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human P2RX4-3499HCL Recombinant Human P2RX4 293 Cell Lysate HEK293 N/A
    Human P2RX4-3802H Recombinant Human P2RX4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human P2RX4-493H Recombinant Human P2RX4 Mammalian Cell His
    Mouse P2RX4-2736M Recombinant Mouse P2RX4 Protein (55-338 aa), His-SUMO-tagged in vitro E. coli His/SUMO
    Mouse P2rx4-4637M Recombinant Mouse P2rx4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat P2RX4-4229R Recombinant Rat P2RX4 Protein Mammalian Cell His
    Chicken P2RX4-5864C Recombinant Chicken P2RX4 Mammalian Cell His

    p2rx4 involved in several pathways and played different roles in them. We selected most pathways p2rx4 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with p2rx4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway GNAQ; PLCE1; PRKACG; ORAI3; CACNA1SB; CAMK2G1; CHRM1; HTR2A; TNNC1; AGTR1A
    Neuroactive ligand-receptor interaction GABRD; KISS1RB; TBXA2R; CALCRLA; TAAR10; GRIA2A; GHRHRL; NPBWR2; PTGER4B; KISS1R

    p2rx4 has several biochemical functions, for example, ATP binding, cadherin binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by p2rx4 itself. We selected most functions p2rx4 had, and list some proteins which have the same functions with p2rx4. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding DDX47; ASS1; FICD; PAK6; CLK2; NLRP4; HSPA12A; CAMKK1A; CKBB; KIF18B
    cadherin binding AKAP5; PTPRM; CTNNB1; CTNND1; CTNNA1; Fert2; CTNNA3; MMP24; CTNNAL1; OLFM4
    copper ion binding PRND; LOXL5B; RNF7; COX17; ATP7B; GPC1; CUTC; CCC2; IL1A; SOD1
    drug binding NR1I2; DCK; GABRA1; SRP54A; CYP2C9; PPARD; GRIK1; SFRP1; DHODH; PDE4C
    extracellular ATP-gated cation channel activity P2RX3A; P2RX2; P2RX6; NNR; P2RX4A; P2RX1; P2RX4; P2RX3B; P2RX7; P2RX8
    protein binding ERBB3; COG3; ARHGEF2; TCAP; PEX3; GCET2; ZNF41; BSCL2; FAM49B; TMBIM6
    protein homodimerization activity LILRB1; CRTAM; GAMT; CARD8; LGALS6; ERBB4; ADRA2C; NKX2; S100A5; TRIM8
    purinergic nucleotide receptor activity P2RX4A; P2RX1; P2RX3; P2RX5; P2RX3B; P2RX7; P2RX4; NNR; P2RX8; P2RX4B
    receptor binding CSK; FYB; HNF4A; RND1; SELPLG; AKAP9; KCNA5; PPY; APOF; EDA
    zinc ion binding Car12; LHX2B; ADAMTS13; MMP9; TRIM58; DTX3; NR1I2; RFWD2; MIB1; CHD4A

    p2rx4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with p2rx4 here. Most of them are supplied by our site. Hope this information will be useful for your research of p2rx4.

    KRTAP5-9; NOTCH2NL; PIH1D3; MCM2; WNT4; opuD

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