P2RX4

  • Official Full Name

    purinergic receptor P2X, ligand-gated ion channel, 4

  • Overview

    The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
  • Synonyms

    P2RX4; purinergic receptor P2X, ligand-gated ion channel, 4; P2X4; P2X4R; P2X purinoceptor 4; ATP receptor; purinoceptor P2X4; P2X receptor, subunit 4; purinergic receptor P2X4; ATP-gated cation channel protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • in vitro E. coli
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human P2RX4-493H Recombinant Human P2RX4 Mammalian Cell His
Human P2RX4-3499HCL Recombinant Human P2RX4 293 Cell Lysate HEK293 N/A
Human P2RX4-3802H Recombinant Human P2RX4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human P2RX4-301584H Recombinant Human P2RX4 protein, GST-tagged E.coli GST Thr57-Ser341
Human P2RX4-2537H Recombinant Human P2RX4 Protein, His-tagged E.coli N-His Asn75-Asn338
Human P2RX4-1594H Recombinant Human P2RX4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human P2RX4-1755HFL Recombinant Full Length Human P2RX4 Protein, C-Flag-tagged Mammalian cells Flag
Human P2RX4-1594H-B Recombinant Human P2RX4 Protein Pre-coupled Magnetic Beads HEK293
Mouse P2rx4-4637M Recombinant Mouse P2rx4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse P2rx4-1889M Recombinant Mouse P2rx4 Protein, His-tagged E.coli N-His Gln55-Asn338
Mouse P2RX4-2736M Recombinant Mouse P2RX4 Protein (55-338 aa), His-SUMO-tagged in vitro E. coli His/SUMO 55-338 aa
Rat P2RX4-4229R Recombinant Rat P2RX4 Protein Mammalian Cell His
Rat P2RX4-3891R Recombinant Rat P2RX4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat P2RX4-3891R-B Recombinant Rat P2RX4 Protein Pre-coupled Magnetic Beads HEK293
Chicken P2RX4-5864C Recombinant Chicken P2RX4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

P2RX4 involved in several pathways and played different roles in them. We selected most pathways P2RX4 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwaySLC25A5;AGTR1B;SLC8A1;PHKA2;P2RX1;TBXA2R;TNNC1;STIM2;AKR1C1
Neuroactive ligand-receptor interactionDRD1B;NTSR1;PTGIR;DRD4A;APLNRA;PRP2;GPR50;THRB;GH1

P2RX4 has several biochemical functions, for example, ATP binding, cadherin binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX4 itself. We selected most functions P2RX4 had, and list some proteins which have the same functions with P2RX4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDDX39;GSK3A;CSNK1D;GSK3B;PSMC5;RET;EIF2AK4;MYO5A;ABCB6A
cadherin bindingOLFM4;CTNNA3;TRPC4;NUMB;JUPA;CD46;NDRG1;CTNNAL1;FER
copper ion bindingDCT;LOXL3;DBH;PAM;TRP53;LOXL2A;SNAI3;AOC1;S100V2
drug bindingP2RX1;CHRNA2;PDE4C;GRIK1;PIGC;CYP2C9;PPP3CA;ADH1;FOLR2
extracellular ATP-gated cation channel activityNNR;P2RX3B;P2RX6;P2RX8;P2RX4B;P2RX4A;P2RX3A;P2RX1;P2RX2
protein bindingISOC1;EIF3M;DPYSL3;C20orf195;UPP2;LGR5;TCAP;TET2;AFF4
protein homodimerization activityGCH1;BLOC1S6;TOX3;RAP1GAP;SMAD4;PDGFB;SLC11A1;Fzd4;BAK1
purinergic nucleotide receptor activityP2RX4;P2RX6;P2RX3B;P2RX4A;P2RX8;P2RX3;P2RX3A;NNR;P2RX1
receptor bindingIDE;DAO1;CSK;ALCAM;AGRP2;ADAM10;Ar;POU2F1;PANX1
zinc ion bindingBRAP;TRIM54;ZMAT3;ZNRF2;USP16;RNF222;BTR06;ZNF205;LTA4H

P2RX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RX4.

KRTAP5-9; NOTCH2NL; PIH1D3; MCM2; WNT4; opuD

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