Recombinant Full Length Human P2RX4 Protein, C-Flag-tagged

• Cat.No.: P2RX4-1755HFL
• Product Overview: Recombinant Full Length Human P2RX4 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 43.2 kDa
• AA Sequence: MAGCCAALAAFLFEYDTPRIVLIRS RKVGLMNRAVQLLILAYVIGWVFVW EKGYQETDSVVSSVTTKVKG VAVTNTSKLGFRIWDVADYVIPAQE ENSLFVMTNVILTMNQTQGLCPEIP DATTVCKSDASCTAGSAGTH SNGVSTGRCVAFNGSVKTCEVAAWC PVEDDTHVPQPAFLKAAENFTLLVK NNIWYPKFNFSKRNILPNIT TTYLKSCIYDAKTDPFCPIFRLGKI VENAGHGFQDMAVEGGIMGIQVNWD CNLDRAASLCLPRYSFRRLD TRDVEHNVSPGYNFRFAKYYRDLAG NEQRTLIKAYGIRFDIIVFGKAGKF DIIPTMINIGSGLALLGMAT
  VLCDIIVLYCMKKRLYYREKKYKYV EDYEQGLASELDQTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Ion Channels: ATP Receptors, Transmembrane
• Protein Pathways: Calcium signaling pathway, Neuroactive ligand-receptor interaction

Gene Information

• Gene Name: P2RX4 purinergic receptor P2X 4 [ Homo sapiens (human) ]
• Official Symbol: P2RX4
• Synonyms: P2X4; P2X4R
• Gene ID: 5025
• mRNA Refseq: NM_002560.3
• Protein Refseq: NP_002551.2
• MIM: 600846
• UniProt ID: Q99571