P2RX7

  • Official Full Name

    P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7

  • Synonyms

    P2RX7;purinergic receptor P2X, ligand-gated ion channel, 7;P2X purinoceptor 7;ATP receptor;P2Z receptor;P2X7 purinoceptor;purinergic receptor P2X7

Recombinant Proteins

  • Human
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cells
  • Wheat Germ
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
P2RX7-1494H Recombinant Human P2RX7, GST-tagged E.coli Human GST C-term-350aa
P2RX7-3635H Recombinant Human P2RX7 protein, His-tagged E.coli Human His 382-589 aa
P2RX7-391H Recombinant Human P2RX7 Protein, His-tagged E.coli Human His Ser47~Val334
P2RX7-1219H Active Recombinant Human P2RX7 Full Length Transmembrane protein(Nanodisc) HEK293 Human Non Full L.
P2RX7-4232R Recombinant Rat P2RX7 Protein Mammalian Cells Rat His
P2RX7-9888Z Recombinant Zebrafish P2RX7 Mammalian Cells Zebrafish His
P2RX7-3495HCL Recombinant Human P2RX7 293 Cell Lysate HEK293 Human Non
P2RX7-3894R Recombinant Rat P2RX7 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
P2RX7-3894R-B Recombinant Rat P2RX7 Protein Pre-coupled Magnetic Beads HEK293 Rat
P2RX7-390H Recombinant Human P2RX7 Protein, GST-tagged Wheat Germ Human GST 1-595
P2RX7-4779H Recombinant Human P2RX7 Protein (Asp356-Tyr595), N-His tagged E.coli Human His Asp356-Tyr595
P2RX7-6868HF Recombinant Full Length Human P2RX7 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 595 amino acids

    Involved Pathway

    P2RX7 involved in several pathways and played different roles in them. We selected most pathways P2RX7 participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway GRPR,HTR5A,TNNC2,AGTR1,ADCY1A,ADRA1BB,ITPR1,F2R,CACNA1H,PLCD4
    Neuroactive ligand-receptor interaction AVPR2,GRM7,GRIA4,TAAR13B,GALR3,C3AR1,TAAR14B,TAAR12E,LPAR4,HTR1A

    Protein Function

    P2RX7 has several biochemical functions, for example, ATP binding,extracellular ATP-gated cation channel activity,lipopolysaccharide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX7 itself. We selected most functions P2RX7 had, and list some proteins which have the same functions with P2RX7. You can find most of the proteins on our site.

    Function Related Protein
    extracellular ATP-gated cation channel activity NNR,P2RX6,P2RX3B,P2RX8,P2RX3,P2RX5,P2RX3A,P2RX4B,P2RX4,P2RX1
    lipopolysaccharide binding HSPD1,TLR4,LBP,BPI,SCARB1,BPIFA2,CD6,TREM2,DROSHA,HMGB1
    protein binding RPLP2,AARSD1,RELB,AAK1,NAV1,VPS26A,EIF3B,BRIP1,FRAS1,PRKD3
    purinergic nucleotide receptor activity P2RX1,P2RX3B,P2RX3,NNR,P2RX8,P2RX5,P2RX6,P2RX4B,P2RX4,P2RX3A
    protein homodimerization activity RABEP1,DLK2,USF2,EPHX2,ACCS,BHLHB9,DPY30,DPP4,SNRPC,MAOB
    receptor binding AMACR,TNFSF9,ALCAM,WNT2BB,LIF,FRK,WNT11R,GCG,LAMA2,PSPN
    ATP binding CDK2,PFKM,OAS2,UBE2D2A,CAMK1GB,MTOR,ACSS2,G3BP1,SMARCAD1,AK1

    Interacting Protein

    P2RX7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RX7 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RX7.

    ABL1;NCK1;GRB2;CASK;TM9SF1;EFNB3

    Resources

    Research Area

    Ion Channels and Regulators

    References

    • Bertelli, R; Di Donato, A; et al. LPS Nephropathy in Mice Is Ameliorated by IL-2 Independently of Regulatory T Cells Activity. PLOS ONE 9:-(2014).
    • Furlan-Freguia, C; Marchese, P; et al. P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice. JOURNAL OF CLINICAL INVESTIGATION 121:2932-2944(2011).

    Reviews

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    Q&As

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    I am interested on P2X7 insertion on arificial bilayer for single channel functional measurements. Do you think this product would fit? 06/11/2024

    To perform single channel functional measurements on the P2X7 protein, there are several requirements that need to be considered: 1. Purification of the P2X7 protein: The P2X7 protein needs to be purified to ensure that only the target protein is inserted into the artificial bilayer membrane for measurements. This typically involves expression and purification of the protein from a suitable expression system such as mammalian cells or bacteria. 2. Protein stability: The P2X7 protein needs to be stable in order to maintain its structure and function during the insertion process and measurements. Proper handling and storage conditions should be maintained to prevent protein degradation. 3. Protein concentration: The concentration of the P2X7 protein should be optimized for successful insertion into the artificial bilayer membrane. Too low of a concentration may result in insufficient protein insertion, while too high of a concentration may lead to non-specific binding or aggregation. Based on the above factors, we suppose P2RX7-1219H is a suitable protein for your application. This full length protein is very stable even at RT and its purity is greater than 90%. It is in lyophilized form and you can resolve it at your ideal concentration.

    I'm contacting you with regard to command P2RX7 Protein to carry on Western Blot experiments on human celles (Jeg-3...) . Which one could be a better candidate in your catalog, if you can recommand me? 12/08/2023

    Based on your requests, we would like to recommend you choose our cell lysate which contains full-length P2RX7 protein. It is suitable for Western Blot assay.

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