P2RX7 involved in several pathways and played different roles in them. We selected most pathways P2RX7 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Calcium signaling pathway |
GRIN1B; P2RX5; GRIN1A; AVPR1B; ITPR3; PTGER1; PTGER1A; MYLK3; CACNA1BA; GRM5 |
| Neuroactive ligand-receptor interaction |
BRS3; TSHB; NMUR2; P2RY6; TAAR12H; CRHR2; CHRNA2A; LTB4R2; LEP; TAAR64 |
P2RX7 has several biochemical functions, for example, ATP binding, extracellular ATP-gated cation channel activity, lipopolysaccharide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX7 itself. We selected most functions P2RX7 had, and list some proteins which have the same functions with P2RX7. You can find most of the proteins on our site.
| Function |
Related Protein |
| ATP binding |
EPHB4A; PSMC1A; MAP2K4B; SBK1; CSF1RA; CDKL5; PTK6; HUNK; TWF2; PAK1 |
| extracellular ATP-gated cation channel activity |
P2RX8; NNR; P2RX6; P2RX1; P2RX3; P2RX4; P2RX4B; P2RX4A; P2RX3A; P2RX2 |
| lipopolysaccharide binding |
BPIFC; RNASE7; CD14; LBP; SPON2; TLR4; CD6; KIAA0644; TREM2; BPI |
| protein binding |
MTAP1A; UCHL5; ZNF3; CHMP2B; KRTAP5-9; VSNL1; CD2; FAM109B; LAMTOR1; PEX11G |
| protein homodimerization activity |
TENM2; KCNH2; CAV2; ERN1; FAP; GPD1L; RCHY1; Trl; WHRN; TRIM5 |
| purinergic nucleotide receptor activity |
P2RX3; P2RX7; P2RX4B; P2RX4A; P2RX5; P2RX1; P2RX3A; P2RX8; P2RX4; P2RX2 |
| receptor binding |
CXCL1; FGF8A; Artn; PVRL2; NSG1; TESPA1; IFNL3; Fgf15; ANGPTL2; HMGCL |
P2RX7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RX7 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RX7.
ABL1; NCK1; GRB2; CASK; TM9SF1; EFNB3
Bertelli, R; Di Donato, A; et al. LPS Nephropathy in Mice Is Ameliorated by IL-2 Independently of Regulatory T Cells Activity. PLOS ONE 9:-(2014).
Furlan-Freguia, C; Marchese, P; et al. P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice. JOURNAL OF CLINICAL INVESTIGATION 121:2932-2944(2011).
