Recombinant Full Length Human P2RX7 Protein, GST-tagged

• Cat.No.: P2RX7-6868HF
• Product Overview: Human P2RX7 full-length ORF ( AAH11913.1, 1 a.a. - 595 a.a.) recombinant protein with GST-tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 94.9 kDa
• Protein Length: 595 amino acids
• AA Sequence: MPACCSCSDVFQYETNKVTRIQSMN YGTIKWFFHVIIFSYVCFALVSDKL YQRKEPVISSVHTKVKGIAEVKEEI VENGVKKLVHSVFDTADYTFPLQGN SFFVMTNFLKTEGQEQRLCPEYPTR RTLCSSDRGCKKGWMDPQSKGIQTG RCVVHEGNQKTCEVSAWCPIEAVEE APRPALLNSAENFTVLIKNNIDFPG HNYTTRNILPGLNITCTFHKTQNPQ CPIFRLGDIFRETGDNFSDVAIQGG IMGIEIYWDCNLDRWFHHCHPKYSF RRLDDKTTNVSLYPGYNFRYAKYYK ENNVEKRTLIKVFGIRFDILVFGTG GKFDIIQLVVYIGSTLSYFGLAAVF IDFLIDTYSSNCCRSHIYPWCKCCQ PCVVNEYYYRKKCESIVEPKPTLKY VSFVDESHIRMVNQQLLGRSLQDVK GQEVPRPAMDFTDLSRLPLALHDTP PIPGQPEEIQLLRKEATPRSRDSPV WCQCGSCLPSQLPESHRCLEELCCR KKPGACITTSELFRKLVLSRHVLQF LLLYQEPLLALDVDSTNSRLRHCAY RCYATWRFGSQDMADFAILPSCCRW RIRKEFPKSEGQYSGFKSPY
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: P2RX7 purinergic receptor P2X 7 [ Homo sapiens (human) ]
• Official Symbol: P2RX7
• Synonyms: P2RX7; purinergic receptor P2X 7; P2X7; P2X purinoceptor 7; ATP receptor; P2X7 receptor; P2Z receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X7 variant A; purnergic receptor P2X 7
• Gene ID: 5027
• mRNA Refseq: NM_002562
• Protein Refseq: NP_002553
• MIM: 602566
• UniProt ID: Q99572