P2RY1
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Official Full Name
purinergic receptor P2Y, G-protein coupled, 1
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Background
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor;subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine;nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to;mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably;to platelet aggregation. -
Synonyms
P2RY1; purinergic receptor P2Y, G-protein coupled, 1; P2Y purinoceptor 1; P2Y1; ATP receptor; platelet ADP receptor; P2 purinoceptor subtype Y1;
- Involved Pathway
- Protein Function
- Interacting Protein
P2RY1 involved in several pathways and played different roles in them. We selected most pathways P2RY1 participated on our site, such as Rap signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | ITGB2L;LPAR2;TLN1;RAPGEF5;BCAR1;LAT;FGF20;ITGAM;VASP |
| Neuroactive ligand-receptor interaction | NTSR2;GRIA1;DRD4B;NPY2R;GRIA2A;NPFFR1L3;P2RY4;RXFP2A;NPY5R |
| Platelet activation | GP6;NOS3;PIK3CB;PLA2G4A;FERMT3;PPP1CA;P2RY12;PRKG1;PPP1CB |
P2RY1 has several biochemical functions, for example, A1 adenosine receptor binding, ADP binding, ADP-activated adenosine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RY1 itself. We selected most functions P2RY1 had, and list some proteins which have the same functions with P2RY1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| A1 adenosine receptor binding | |
| ADP binding | LONP1;HSP104;CYB5R3;ERN1;APAF1;CHORDC1;ME1;ADCK3;TAP1 |
| ADP-activated adenosine receptor activity | |
| ATP binding | ABCA8;PEX1;H1FNT;PIM3;HSPA4B;PANK3;PSMC1A;MYO1C;ABCA9 |
| ATP-activated adenosine receptor activity | P2RY11;P2RY1 |
| G-protein coupled purinergic nucleotide receptor activity | GPR34B;P2RY13;P2RY4;P2RY14;P2RY11;GPR171;P2RY6;PTAFR;P2RY1 |
| protein binding | RNF165;TLDC2;ATG4B;DPF2;FAM54B;TMEM110;DUSP26;CDC42EP5;DNAJB9 |
| protein heterodimerization activity | H2AFB3;AOC3;SDCBP;TOP2A;ADORA1;THRA;HIST1H2AK;BCL2L1;PAFAH1B2 |
| receptor activity | CSF2RA;TNFRSF11A;CADM1;SIGLEC7;VMN1R48;VAC14;NR2C2;V1RA8;TNFRSF10B |
| scaffold protein binding | NLRP1;MDM2;PARK7;NLGN1;PDE4D;KCNA5;KRT15;CACNA1H;LRP4 |
P2RY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RY1.
SLC9A3R1
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