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P2RY1

  • Official Full Name

    purinergic receptor P2Y, G-protein coupled, 1

  • Overview

    The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor;subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine;nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to;mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably;to platelet aggregation.
  • Synonyms

    P2RY1; purinergic receptor P2Y, G-protein coupled, 1; P2Y purinoceptor 1; P2Y1; ATP receptor; platelet ADP receptor; P2 purinoceptor subtype Y1;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Cavia porcellus (Guinea pig)
  • Chicken
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Meleagris gallopavo (Wild turkey)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli expression system
  • HEK293
  • In vitro E. coli expression system
  • Insect Cell
  • Mammalian Cell
  • Flag
  • Flag,His
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human P2RY1-1267HCL Recombinant Human P2RY1 cell lysate N/A
Human P2RY1-1102HFL Recombinant Human P2RY1 protein, His&Flag-tagged HEK293 His&Flag 1-373 aa
Human P2RY1-0968H Recombinant Human P2RY1 Protein (T2-L373), Flag tagged Insect Cell Flag T2-L373
Human P2RY1-0969H Recombinant Human P2RY1 Protein (T2-L373), Flag, His tagged Insect Cell Flag,His T2-L373
Mouse P2RY1-12272M Recombinant Mouse P2RY1 Protein Mammalian Cell His
Mouse P2ry1-0496M Recombinant Mouse P2ry1 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-373aa
Mouse P2RY1-6457M Recombinant Mouse P2RY1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse P2RY1-6457M-B Recombinant Mouse P2RY1 Protein Pre-coupled Magnetic Beads HEK293
Rat P2RY1-4233R Recombinant Rat P2RY1 Protein Mammalian Cell His
Rat P2RY1-3895R-B Recombinant Rat P2RY1 Protein Pre-coupled Magnetic Beads HEK293
Rat P2RY1-3895R Recombinant Rat P2RY1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL11785BF Recombinant Full Length Bovine P2Y Purinoceptor 1(P2Ry1) Protein, His-Tagged E.coli expression system His Full Length (1-373)
Cavia porcellus (Guinea pig) RFL22570CF Recombinant Full Length Guinea Pig P2Y Purinoceptor 1(P2Ry1) Protein, His-Tagged E.coli expression system His Full Length (1-373)
Gallus gallus (Chicken) RFL35980GF Recombinant Full Length Chicken P2Y Purinoceptor 1(P2Ry1) Protein, His-Tagged E.coli expression system His Full Length (1-362)
Homo sapiens (Human) RFL16968HF Recombinant Full Length Human P2Y Purinoceptor 1(P2Ry1) Protein, His-Tagged E.coli expression system His Full Length (1-373)
Meleagris gallopavo (Wild turkey) RFL10242MF Recombinant Full Length Meleagris Gallopavo P2Y Purinoceptor 1(P2Ry1) Protein, His-Tagged E.coli expression system His Full Length (1-362)
Mus musculus (Mouse) RFL23483MF Recombinant Full Length Mouse P2Y Purinoceptor 1(P2Ry1) Protein, His-Tagged E.coli expression system His Full Length (1-373aa)
Rattus norvegicus (Rat) RFL35653RF Recombinant Full Length Rat P2Y Purinoceptor 1(P2Ry1) Protein, His-Tagged E.coli expression system His Full Length (1-373)
Rhesus Macaque P2RY1-3269R Recombinant Rhesus monkey P2RY1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque P2RY1-3087R Recombinant Rhesus Macaque P2RY1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque P2RY1-3087R-B Recombinant Rhesus Macaque P2RY1 Protein Pre-coupled Magnetic Beads HEK293
Chicken P2RY1-6885C Recombinant Chicken P2RY1 Mammalian Cell His
Kit-1467 P2RY1 U2OS β-Arrestin GPCR Assay Kit N/A
Kit-1468 P2RY1 Activated GPCR Internalization Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein

P2RY1 involved in several pathways and played different roles in them. We selected most pathways P2RY1 participated on our site, such as Rap signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayMAPK13;RAP1A;RAC2;PRKD2;KIT;MAPK1;PDGFRA;PRKCZ;PIK3R1
Neuroactive ligand-receptor interactionOPRD1B;RXFP2;GRIA2A;P2RX3A;CSH2;PRLR;CYSLTR2;GRIA4B;THRB
Platelet activationMYLK4;GUCY1B3;PRKACG;PIK3CG;GNAI3;VAMP8;FYN;MAPK3;ROCK2

P2RY1 has several biochemical functions, for example, A1 adenosine receptor binding, ADP binding, ADP-activated adenosine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RY1 itself. We selected most functions P2RY1 had, and list some proteins which have the same functions with P2RY1. You can find most of the proteins on our site.

Function Related Protein
A1 adenosine receptor binding
ADP bindingMYH9;CHORDC1;MYO18A;ACTA1;VCP;GLUD1;ADCK3;GCLC;PRKAG2
ADP-activated adenosine receptor activity
ATP bindingATP6V1B1;DDX17;UBE2T;ATP2A1;ABCA1;MYLK3;NLRP9B;DCK;PRKCH
ATP-activated adenosine receptor activityP2RY11;P2RY1
G-protein coupled purinergic nucleotide receptor activityP2RY11;GPR34B;P2RY13;P2RY10;P2RY8;PTAFR;P2RY14;P2RY1;P2RY4
protein bindingCX3CL1;DDB1;FOSL2;PRICKLE1;FAM134B;IWS1;MAPK8;ARF5;SCNN1B
protein heterodimerization activitySPNA1;TAF4B;SUPT5H;CEBPE;HNF1B;DMBX1;PPP2R4;TXLNG;HIST1H4L
receptor activityOR3A2;NEO1;KIR2DL3;GUCY1B3;VMN1R46;FPR1;NLGN4Y;ATRN;GRIA3B
scaffold protein bindingCRIPT;SCN5A;NLGN4Y;KRT18;CACNA1H;MAP2K2;IKBKB;GRIN2A;SHANK3

P2RY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RY1.

SLC9A3R1

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