• Official Full Name

    purinergic receptor P2Y, G-protein coupled, 1

  • Background

    The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor;subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine;nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to;mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably;to platelet aggregation.
  • Synonyms

    P2RY1; purinergic receptor P2Y, G-protein coupled, 1; P2Y purinoceptor 1; P2Y1; ATP receptor; platelet ADP receptor; P2 purinoceptor subtype Y1;
    • Type:
    • Assay Kits
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • HEK293
    • In vitro E. coli expression system
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • Flag
    • Flag,His
    • His
    • His (Fc)
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Kit-1468 P2RY1 Activated GPCR Internalization Assay Kit N/A
    Kit-1467 P2RY1 U2OS β-Arrestin GPCR Assay Kit N/A
    Chicken P2RY1-6885C Recombinant Chicken P2RY1 Mammalian Cell His
    Human P2RY1-1267HCL Recombinant Human P2RY1 cell lysate N/A
    Human P2RY1-1102HFL Recombinant Human P2RY1 protein, His&Flag-tagged HEK293 His&Flag
    Human P2RY1-0968H Recombinant Human P2RY1 Protein (T2-L373), Flag tagged Insect Cell Flag
    Human P2RY1-0969H Recombinant Human P2RY1 Protein (T2-L373), Flag, His tagged Insect Cell Flag,His
    Mouse P2RY1-6457M Recombinant Mouse P2RY1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse P2ry1-0496M Recombinant Mouse P2ry1 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His
    Mouse P2RY1-12272M Recombinant Mouse P2RY1 Protein Mammalian Cell His
    Mouse P2RY1-6457M-B Recombinant Mouse P2RY1 Protein Pre-coupled Magnetic Beads HEK293
    Rat P2RY1-4233R Recombinant Rat P2RY1 Protein Mammalian Cell His
    Rat P2RY1-3895R-B Recombinant Rat P2RY1 Protein Pre-coupled Magnetic Beads HEK293
    Rat P2RY1-3895R Recombinant Rat P2RY1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque P2RY1-3087R Recombinant Rhesus Macaque P2RY1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque P2RY1-3087R-B Recombinant Rhesus Macaque P2RY1 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque P2RY1-3269R Recombinant Rhesus monkey P2RY1 Protein, His-tagged Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein

    P2RY1 involved in several pathways and played different roles in them. We selected most pathways P2RY1 participated on our site, such as Rap signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathwayITGB2L;LPAR2;TLN1;RAPGEF5;BCAR1;LAT;FGF20;ITGAM;VASP
    Neuroactive ligand-receptor interactionNTSR2;GRIA1;DRD4B;NPY2R;GRIA2A;NPFFR1L3;P2RY4;RXFP2A;NPY5R
    Platelet activationGP6;NOS3;PIK3CB;PLA2G4A;FERMT3;PPP1CA;P2RY12;PRKG1;PPP1CB

    P2RY1 has several biochemical functions, for example, A1 adenosine receptor binding, ADP binding, ADP-activated adenosine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RY1 itself. We selected most functions P2RY1 had, and list some proteins which have the same functions with P2RY1. You can find most of the proteins on our site.

    Function Related Protein
    A1 adenosine receptor binding
    ADP-activated adenosine receptor activity
    ATP-activated adenosine receptor activityP2RY11;P2RY1
    G-protein coupled purinergic nucleotide receptor activityGPR34B;P2RY13;P2RY4;P2RY14;P2RY11;GPR171;P2RY6;PTAFR;P2RY1
    protein bindingRNF165;TLDC2;ATG4B;DPF2;FAM54B;TMEM110;DUSP26;CDC42EP5;DNAJB9
    protein heterodimerization activityH2AFB3;AOC3;SDCBP;TOP2A;ADORA1;THRA;HIST1H2AK;BCL2L1;PAFAH1B2
    receptor activityCSF2RA;TNFRSF11A;CADM1;SIGLEC7;VMN1R48;VAC14;NR2C2;V1RA8;TNFRSF10B
    scaffold protein bindingNLRP1;MDM2;PARK7;NLGN1;PDE4D;KCNA5;KRT15;CACNA1H;LRP4

    P2RY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RY1.


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