PANX1
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Official Full Name
pannexin 1
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Overview
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. -
Synonyms
PANX1; pannexin 1; pannexin-1; innexin; MRS1; PX1; UNQ2529; PANX1_HUMAN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rat
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | PANX1-1348H | Recombinant Human PANX1 protein, His & T7-tagged | E.coli | His/T7 | Cys228~Asn411 (Accession # Q96RD7) |
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| Human | PANX1-3443HCL | Recombinant Human PANX1 293 Cell Lysate | HEK293 | N/A |
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| Human | PANX1-301600H | Recombinant Human PANX1 protein, GST-tagged | E.coli | GST | Phe126-Cys426 |
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| Mouse | PANX1-12337M | Recombinant Mouse PANX1 Protein | Mammalian Cell | His |
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| Mouse | PANX1-6486M-B | Recombinant Mouse PANX1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | PANX1-6486M | Recombinant Mouse PANX1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | Panx1-1349R | Recombinant Rat Panx1 protein, His-tagged | E.coli | His | Ala77~Asp260 (Accession # P60570) |
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| Homo sapiens (Human) | RFL11599HF | Recombinant Full Length Human Pannexin-1(Panx1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-426) |
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| Mus musculus (Mouse) | RFL4478MF | Recombinant Full Length Mouse Pannexin-1(Panx1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-426) |
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| Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) | RFL14787PF | Recombinant Full Length Pongo Abelii Pannexin-1(Panx1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-426) |
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| Rattus norvegicus (Rat) | RFL4250RF | Recombinant Full Length Rat Pannexin-1(Panx1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-426) |
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- Involved Pathway
- Protein Function
- Interacting Protein
- PANX1 Related Articles
- PANX1 Related Research Area
PANX1 involved in several pathways and played different roles in them. We selected most pathways PANX1 participated on our site, such as Electric Transmission Across Gap Junctions, Immune System, Inflammasomes, which may be useful for your reference. Also, other proteins which involved in the same pathway with PANX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Electric Transmission Across Gap Junctions | PANX2;GJA10;PANX1;PANX1B;PANX1A;GJC1 |
| Immune System | NLRP4;PPAPDC1A;DEFB116;ARIH1;SRMS;AP1B1;PJA2;CLEC2G;KPNA3 |
| Inflammasomes | BTR02;PANX1;BTR09;TXNIP;BTR29;BTR22;BTR12;TXNIPB;PANX1A |
| Innate Immune System | ABI1B;DEFB106A;DEFA1;CRCP;CRP;NLRP4B;DEFB4A;BTR06;NCKAP1 |
| Neuronal System | KCND3;KCND1;SNAP25A;KCNAB2;KCNQ3;KCNK2;PPFIA1;KCNH1B;RAB3AB |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | BTR02;NLRP3;CYLD;PANX1;TXNIPA;BTR18;TXNIP;SUGT1;CASP4 |
| The NLRP3 inflammasome | SUGT1;BTR22;PANX1B;BTR18;PANX1A;BTR09;TXNIPB;BTR29;BTR30 |
| Transmission across Electrical Synapses | PANX1;PANX1B;PANX1A;GJA10;PANX2;GJC1 |
PANX1 has several biochemical functions, for example, actin filament binding, calcium channel activity, gap junction hemi-channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PANX1 itself. We selected most functions PANX1 had, and list some proteins which have the same functions with PANX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin filament binding | DBNLB;PPP1R9A;FMNL1;TLN1;TLN2A;DBNLA;TAGLN3B;ACTN4;SSFA2 |
| calcium channel activity | PSEN1;CHRNA9;SLC24A2;CACNB2;TRPC4B;CACNA1C;MCU;PKD2L1;RYR1B |
| gap junction hemi-channel activity | GJA5;CX43;CX35B;CX36.7;PANX1A;CX44.1;CX52.6;PANX1;CX55.5 |
| ion channel binding | HTT;KCNE4;PRNP;FYN;CALM1;PKD2;AASS;PDE4B;YWHAH |
| leak channel activity | |
| protease binding | SERPINB9;FN1;TTN;MBP;TP53;TIMP3;TRP53;THAP5;SERPINB3 |
| protein heterodimerization activity | SLC51B;DDIT3;F11R.1;SIM1;ATP4A;HIST1H2AC;FLOT1;IRAK2;BOKB |
| receptor binding | TNFSF10;MTSS1;SRI;GFRA3;PECR;NPPC;ADIPOQ;MATK;IL28A |
| scaffold protein binding | KRT5;NCK2;DSP;CASP8;LRP4;CHRNA7;NOS3;IKBKB;GRIN2A |
PANX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PANX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PANX1.
P2rx7; BAG3; Kif4; Smo; CDC37; FBXO7
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