PANX1
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Official Full Name
pannexin 1 -
Overview
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. -
Synonyms
PANX1;pannexin 1;pannexin-1;innexin;MRS1;PX1;UNQ2529;PANX1_HUMAN
Recombinant Proteins
- Mouse
- Human
- Rat
- Pongo Abelii
- Mus musculus
- Mammalian Cells
- E.coli
- HEK293
- His
- T7
- Non
- GST
- Avi
- Fc
Involved Pathway
PANX1 involved in several pathways and played different roles in them. We selected most pathways PANX1 participated on our site, such as Electric Transmission Across Gap Junctions,Immune System,Inflammasomes, which may be useful for your reference. Also, other proteins which involved in the same pathway with PANX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inflammasomes | BTR12,BTR29,PANX1B,TXNIPA,NLRP3,BTR06,TXNIP,PANX1A,BTR30,BTR16 |
| The NLRP3 inflammasome | BTR30,BTR09,BTR29,PANX1B,BTR16,TXNIPB,BTR22,BTR02,BTR18,BTR12 |
| Transmission across Electrical Synapses | PANX1A,PANX1B,PANX2,GJC1,GJA10 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | BTR30,BTR02,NLRP3,PANX1B,BTR12,BTR18,BTR09,BTR29,CASP4,TXNIPB |
| Neuronal System | KCNA5,ARL6IP5A,DLG1L,KCND3,KCNA10,KCNJ1A.2,KCNK13B,CACNG2B,KCND2,KCNK13A |
| Innate Immune System | WIPF3,BTR06,DEFA6,ABI1A,ABI1,TXNIPA,DEFA5,NLRP4B,FCN1,MGC174155 |
| Electric Transmission Across Gap Junctions | PANX1B,GJC1,PANX1A,PANX2,GJA10 |
| Immune System | CYBA,RNF216,CR1,KLRG1,KIF2C,PIK3AP1,TNFSF13B,CSH1,IFIT2,ATP6V1G3 |
Protein Function
PANX1 has several biochemical functions, for example, actin filament binding,calcium channel activity,gap junction hemi-channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PANX1 itself. We selected most functions PANX1 had, and list some proteins which have the same functions with PANX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ion channel binding | GRINA,KCNH1,RIMS3,AKAP6,KCNIP2,ACTN3,FXYD1,NOS1,HERPUD1,PACS1A |
| scaffold protein binding | DLG4,CHUK,KRT15,KCNH2,CAV2,CACNA1H,NCK2,MAPK3,NLGN4Y,SHANK1 |
| protease binding | TNF,ECM1,INS1,SRI,ALPI,FADD,ANXA2,MBL1,SELL,ELANE |
| actin filament binding | WIPF3,VIL1,TNNC1,SHROOM2,TULP1,FLNC,WIPF1A,SHROOM4,CTNNA2,MYO6 |
| receptor binding | SCP2,CAT,FGF20B,AMN,WNT11R,CADM2A,PTPRD,LAMA3,RSPO2,ARPP19 |
| gap junction hemi-channel activity | CX55.5,CX41.8,GJA5,CX43,CX35B,CX44.1,CX52.6,PANX1A,CX36.7 |
| protein heterodimerization activity | MCL1A,Defa-rs7,MAFG,GABRR1,TTR,PAFAH1B2,HIST1H2AL,HIST1H3F,NFE2L2A,TBX15 |
| calcium channel activity | CACNB2,TRPC6A,TRPC2B,TRPC7B,CACNA1SA,TPCN1,PKD2L1,RYR2,SLC24A4,TRPC5A |
Interacting Protein
PANX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PANX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PANX1.
P2rx7;BAG3;Kif4;Smo;CDC37;FBXO7
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References
- Le Vasseur, M; Lelowski, J; et al. Pannexin 2 protein expression is not restricted to the CNS. FRONTIERS IN CELLULAR NEUROSCIENCE 8:-(2014).
- Taylor, KA; Wright, JR; et al. Amplification of human platelet activation by surface pannexin-1 channels. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 12:987-998(2014).
