PARG
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Official Full Name
poly (ADP-ribose) glycohydrolase
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Overview
Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. [provided by RefSeq, Jul 2008] -
Synonyms
PARG; poly (ADP-ribose) glycohydrolase; PARG99; poly(ADP-ribose) glycohydrolase; mitochondrial poly(ADP-ribose) glycohydrolase; poly(ADP-ribose) glycohydrolase 60 kDa isoform;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- E.coli
- HEK293
- HEK293F
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PARG Related Articles
PARG involved in several pathways and played different roles in them. We selected most pathways PARG participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PARG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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PARG has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PARG itself. We selected most functions PARG had, and list some proteins which have the same functions with PARG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
PARG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARG here. Most of them are supplied by our site. Hope this information will be useful for your research of PARG.
PARP1
- Q&As
- Reviews
Q&As (6)
Ask a questionStudies have shown that the aberrant expression of PARG is related to the occurrence and development of a variety of tumors, such as lung cancer, breast cancer, colon cancer, etc. High expression of PARG may promote the proliferation and metastasis of tumor cells, which is associated with poor prognosis.
There are interactions between PARG and other biomolecules. For example, it interacts with DNA repair enzymes to participate in the DNA repair process, and also interacts with apoptosis-related proteins to regulate the apoptosis process.
Biomolecules that can be used as molecular markers for PAR include its mRNA and protein expression products in tissues and cells, as well as other biomolecules that interact with it (e.g., DNA repair enzymes, apoptosis-related proteins, etc.). These markers can be used for early diagnosis of diseases, prognosis judgment, or monitoring the effectiveness of treatment.
Therapeutic strategies for PAGR include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against PAGR to inhibit its overactivation in tumors, or the regulation of PAGR expression through gene knockout or overexpression techniques.
PARG is mainly involved in DNA repair and apoptosis processes within the cell. When DNA is damaged, PARG promotes the initiation of DNA repair mechanisms to restore the normal function of the cell. If the DNA damage cannot be repaired, PARG is involved in the process of apoptosis, removing the damaged cells.
Evaluating the efficacy and safety of treatments for PARG requires clinical trials and drug monitoring. The effectiveness of the treatment was evaluated by designing a rigorous clinical trial protocol that compared the disease response rate, survival, and quality of life between the treatment and control groups. At the same time, drug monitoring is used to monitor the safety and efficacy of drugs in actual use, adjust treatment regimens in a timely manner, maximize the efficacy of drugs and reduce the risk of side effects.
Customer Reviews (3)
Write a reviewIt is well active and can remain active for a long time.
The preparation process of PAREG is strictly controlled to ensure the quality and safety of the product.
Very convenient to use and highly recommended.
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