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PARN

  • Official Full Name

    poly(A)-specific ribonuclease

  • Overview

    The protein encoded by this gene is a 3-exoribonuclease, with similarity to the RNase D family of 3-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
  • Synonyms

    PARN; poly(A)-specific ribonuclease; DAN; poly(A)-specific ribonuclease PARN; deadenylating nuclease; deadenylation nuclease; polyadenylate-specific ribonuclease; poly(A)-specific ribonuclease (deadenylation nuclease);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PARN-30788TH Recombinant Human PARN Wheat Germ N/A 639 amino acids
Human PARN-3430HCL Recombinant Human PARN 293 Cell Lysate HEK293 N/A
Human PARN-3049H Recombinant Human PARN protein, His-tagged Yeast His 1-639 aa
Human PARN-372H Recombinant Human Lefty1 Protein, His/GST-tagged E.coli His/GST Lys178~Asp245
Human PARN-358HF Recombinant Full Length Human PARN Protein In Vitro Cell Free System 639 amino acids
Human PARN-4799H Recombinant Human PARN Protein (Lys178-Asp245), N-GST tagged E.coli N-GST Lys178-Asp245
Human PARN-1608H Recombinant Human PARN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PARN-3048H Recombinant Human PARN protein, His-tagged E.coli His 1-639 aa
Human PARN-473H Recombinant Human PARN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PARN-548HFL Recombinant Full Length Human PARN Protein, C-Flag-tagged Mammalian cells Flag
Human PARN-1608H-B Recombinant Human PARN Protein Pre-coupled Magnetic Beads HEK293
Mouse PARN-12366M Recombinant Mouse PARN Protein Mammalian Cell His
Mouse Parn-4677M Recombinant Mouse Parn Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PARN-6501M-B Recombinant Mouse PARN Protein Pre-coupled Magnetic Beads HEK293
Mouse PARN-6501M Recombinant Mouse PARN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish PARN-11311Z Recombinant Zebrafish PARN Mammalian Cell His
Chicken PARN-2338C Recombinant Chicken PARN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PARN involved in several pathways and played different roles in them. We selected most pathways PARN participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RNA degradationCNOT3B;EXOSC3;LSM3;CNOT6;PFKP;EXOSC1;WDR61;SKIV2L2;PFKM

PARN has several biochemical functions, for example, mRNA 3-UTR binding, metal ion binding, nuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PARN itself. We selected most functions PARN had, and list some proteins which have the same functions with PARN. You can find most of the proteins on our site.

Function Related Protein
mRNA 3-UTR bindingCPEB2;RBM24A;SERBP1;ZNF385A;HNRNPC;CPEB4;ELAVL1;CRYZ;RBM38
metal ion bindingHDHD2;CH25HL2;ITPK1A;ATP8B3;NR1D4A;NT5M;AGAP5;ZFP629;PRPSAP2
nuclease activityZRANB3;REXO4;HARBI1;MEIOB;RNASEL2;CNOT6L;SND1;USB1;DNASE1L3L
nucleotide bindingRALBB;TGFBR1B;TUBA4L;MYHZ1.1;U2AF2B;RBM12;TLK1B;ATP8B3;SAFB
poly(A) RNA bindingZFP207;UPF1;FAM46A;FNDC3B;RPL6;HHATL;HIST1H4A;SNRPN;TARDBP
poly(A)-specific ribonuclease activityCNOT7;CNOT6L;PARN;CNOT8;CNOT6;TOE1;PAN2;PDE12
protein bindingKIF3B;BACH1;FBL;LMX1A;RERG;DOK6;PLAUR;LIN28B;MYL12B
protein kinase bindingAKAP7;LCK;GYS1;TRAP1;MAVS;MAP3K2;CHEK2;GSK3B;RFFL

PARN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARN here. Most of them are supplied by our site. Hope this information will be useful for your research of PARN.

BARD1; NCBP1; CSTF2; PABPC1; MPHOSPH6; SPATC1L; ssrna_a

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