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PDCD10

  • Official Full Name

    programmed cell death 10

  • Overview

    This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.
  • Synonyms

    PDCD10; programmed cell death 10; CCM3, cerebral cavernous malformations 3; programmed cell death protein 10; TFAR15; apoptosis-related protein 15; TF-1 cell apoptosis-related protein 15; cerebral cavernous malformations 3 protein; CCM3; MGC1212; MGC2447;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human Cells
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • SUMO
  • Myc
  • DDK
  • N/A
  • No tag
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDCD10-170H Recombinant Human PDCD10 protein, T7-tagged E.coli T7
Human PDCD10-10H Recombinant Human PDCD10S1 protein E.coli N/A
Human PDCD10-1590H Recombinant Human PDCD10, GST-tagged E.coli GST 9-101aa
Human PDCD10-3363HCL Recombinant Human PDCD10 293 Cell Lysate HEK293 N/A
Human PDCD10-0879H Recombinant Human PDCD10 Protein (M1-A212), Tag Free E.coli No tag M1-A212
Human PDCD10-2026H Recombinant Human PDCD10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PDCD10-151H Recombinant Human PDCD10 Protein, His-tagged Human Cells His
Human PDCD10-4774H Recombinant Human PDCD10 protein, His-SUMO-tagged E.coli His-SUMO 1-212aa
Human PDCD10-0880H Recombinant Human PDCD10 Protein (M1-A212), His/Strep tagged E.coli His/Strep M1-A212
Mouse PDCD10-12530M Recombinant Mouse PDCD10 Protein Mammalian Cell His
Mouse PDCD10-6571M-B Recombinant Mouse PDCD10 Protein Pre-coupled Magnetic Beads HEK293
Mouse PDCD10-6571M Recombinant Mouse PDCD10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pdcd10-4731M Recombinant Mouse Pdcd10 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PDCD10-4319R Recombinant Rat PDCD10 Protein Mammalian Cell His
Rat PDCD10-3979R-B Recombinant Rat PDCD10 Protein Pre-coupled Magnetic Beads HEK293
Rat PDCD10-3979R Recombinant Rat PDCD10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PDCD10-3339R Recombinant Rhesus monkey PDCD10 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PDCD10-3157R Recombinant Rhesus Macaque PDCD10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PDCD10-3157R-B Recombinant Rhesus Macaque PDCD10 Protein Pre-coupled Magnetic Beads HEK293
Chicken PDCD10-1692C Recombinant Chicken PDCD10 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PDCD10 involved in several pathways and played different roles in them. We selected most pathways PDCD10 participated on our site, such as Validated targets of C-MYC transcriptional activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDCD10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Validated targets of C-MYC transcriptional activationPEG10;PDCD10;HUWE1;MTDH;SERPINI1;DDX18;LIN28B;CDCA7;NDUFAF2

PDCD10 has several biochemical functions, for example, protein N-terminus binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDCD10 itself. We selected most functions PDCD10 had, and list some proteins which have the same functions with PDCD10. You can find most of the proteins on our site.

Function Related Protein
protein N-terminus bindingEXOC4;CSNK2A2;PEX5;NFE2;PDLIM5;ID1;BIRC2;ALG2;SNF8
protein bindingKIF13B;CTBP1;RPL30;ZMAT4;DPF2;HIST1H2AH;UBA5;PARP9;ARMC9
protein homodimerization activityFAM109B;GLA;RXRB;STOM;GRM6;CAMK2B;PVRL3B;SLC26A5;DRD2
protein kinase bindingGCSAM;SQSTM1;BCL10;MAPK8IP2;FGF19;PPME1;TBC1D14;PTPRC;DNM2

PDCD10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDCD10 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDCD10.

STK25; STK24

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