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Official Full Name programmed cell death 10
Background This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms PDCD10; programmed cell death 10; CCM3, cerebral cavernous malformations 3; programmed cell death protein 10; TFAR15; apoptosis-related protein 15; TF-1 cell apoptosis-related protein 15; cerebral cavernous malformations 3 protein; CCM3; MGC1212; MGC2447
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PDCD10-2026H Recombinant Human PDCD10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Pdcd10-4731M Recombinant Mouse Pdcd10 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human PDCD10-10H Recombinant Human PDCD10S1 protein E.coli N/A
    Human PDCD10-1590H Recombinant Human PDCD10, GST-tagged E.coli GST
    Human PDCD10-170H Recombinant Human PDCD10 protein, T7-tagged E.coli T7
    Human PDCD10-3363HCL Recombinant Human PDCD10 293 Cell Lysate HEK293 N/A
    Mouse PDCD10-12530M Recombinant Mouse PDCD10 Protein Mammalian Cell His
    Rat PDCD10-4319R Recombinant Rat PDCD10 Protein Mammalian Cell His
    Rhesus Macaque PDCD10-3339R Recombinant Rhesus monkey PDCD10 Protein, His-tagged Mammalian Cell His
    Chicken PDCD10-1692C Recombinant Chicken PDCD10 Mammalian Cell His

    pdcd10 involved in several pathways and played different roles in them. We selected most pathways pdcd10 participated on our site, such as Validated targets of C-MYC transcriptional activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with pdcd10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Validated targets of C-MYC transcriptional activation MYCT1; PDCD10; MTDH; DDX18; HUWE1; NDUFAF2; SERPINI1; CDCA7; MINA; PRDX3

    pdcd10 has several biochemical functions, for example, protein N-terminus binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by pdcd10 itself. We selected most functions pdcd10 had, and list some proteins which have the same functions with pdcd10. You can find most of the proteins on our site.

    Function Related Protein
    protein N-terminus binding SCFD1; RELA; THAP7; ARF6; TRP53; TARBP2; SLA2; DAXX; CSNK2A1; RBPJ
    protein binding VAPB; CCNF; GTF2H2C_2; Chrng; STBD1; MED24; KLHL20; PGM1; EIF4EBP3L; RBX1
    protein homodimerization activity FAP; NTRK2; Pdgfa&Pdgfb; SP100; ANO2; VAPB; S100A10; GSS; MGLL; TRIM37
    protein kinase binding CALM; MAPKAP1; TRP53; MLKL; RPS6KA3; SOCS1; MAVS; TNNI3; KCNQ3; MVP

    pdcd10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pdcd10 here. Most of them are supplied by our site. Hope this information will be useful for your research of pdcd10.

    STK25; STK24

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