• Official Full Name
  • programmed cell death 10
  • Background
  • This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.
  • Synonyms
  • PDCD10; programmed cell death 10; CCM3, cerebral cavernous malformations 3; programmed cell death protein 10; TFAR15; apoptosis-related protein 15; TF-1 cell apoptosis-related protein 15; cerebral cavernous malformations 3 protein; CCM3; MGC1212; MGC2447
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDCD10S1 protein
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDCD10, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDCD10 protein, T7-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PDCD10 Protein
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDCD10 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PDCD10 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDCD10
Source (Host):Species:Human
Product nameRecombinant Human PDCD10 293 Cell Lysate

Involved Pathway

PDCD10 involved in several pathways and played different roles in them. We selected most pathways PDCD10 participated on our site, such as Validated targets of C-MYC transcriptional activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDCD10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Validated targets of C-MYC transcriptional activation

Protein Function

PDCD10 has several biochemical functions, for example, protein N-terminus binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDCD10 itself. We selected most functions PDCD10 had, and list some proteins which have the same functions with PDCD10. You can find most of the proteins on our site.
Related Protein
Function protein N-terminus binding
Related Protein DCTN4; CSNK2A1; RASSF1; NCOR2; TRP53; ACOX1; ERCC3; RND2; TBL1XR1; ERCC2
Function protein binding
Related Protein IFI35; AGGF1; C18orf56; THEMIS; DIS3; HK1; JAG2; ILVBL; AKAP9; ARAF
Function protein homodimerization activity
Related Protein MZF1; TBX18; TRIM37; IRAK1; ADAM10; CD2; P2RX4; TIMM9; ATG7; FAP
Function protein kinase binding
Related Protein PTPN1; AP2A1; CHEK2; CCNY; TRAF2; GOLGA2; SPAG16; SMAD1; TRIB3; LATS1

Interacting Protein

PDCD10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDCD10 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDCD10.
STK25; STK24