PDP1

  • Official Full Name

    pyruvate dehyrogenase phosphatase catalytic subunit 1

  • Overview

    Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase;complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1;component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation;of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a;heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is;predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic;subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with;the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial;matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced;transcript variants encoding different isoforms have been identified.
  • Synonyms

    PDP1; pyruvate dehyrogenase phosphatase catalytic subunit 1; PPM2C, protein phosphatase 2C, magnesium dependent, catalytic subunit; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; PDH; PDP; PDP 1; PDPC 1; pyruvate dehydrogena;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Flag
  • His
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDP1-698H Recombinant Human PDP1, His-tagged E.coli His
Human PDP1-7881H Recombinant Human PDP1 protein, His & T7-tagged E.coli His/T7
Human PDP1-695H Recombinant Human PDP1, MYC/DDK-tagged HEK293 Myc/DDK
Human PDP1-696H Recombinant Human PDP1, MYC/DDK-tagged HEK293 Myc/DDK
Human PDP1-3324HCL Recombinant Human PDP1 293 Cell Lysate HEK293 N/A
Human PDP1-5468HFL Recombinant Full Length Human PDP1, Flag-tagged Mamanlian cells Flag
Human PDP1-5982H Recombinant Human PDP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PDP1-4965H Recombinant Human PDP1 Protein (Asn315-Glu537), N-His tagged E.coli N-His
Mouse Pdp1-4775M Recombinant Mouse Pdp1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish PDP1-6228Z Recombinant Zebrafish PDP1 Mammalian Cell His
Chicken PDP1-4482C Recombinant Chicken PDP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PDP1 Related Research Area

PDP1 involved in several pathways and played different roles in them. We selected most pathways PDP1 participated on our site, such as Metabolism, Pyruvate metabolism, Pyruvate metabolism and Citric Acid (TCA) cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MetabolismFABP1B.1;APOBB.1;ARL2;MARCKSA;AKR1C2;GLTP;AKR1C4;IVD;SULT2ST1
Pyruvate metabolismPDHB;GLO1;ACOT12;ACSS1;FH;LDHA;ACSS2;PKLR;ME2
Pyruvate metabolism and Citric Acid (TCA) cyclePDP1;PDK2B;D2HGDH;PDPR;SLC16A8;PDK2;PDK3B;BRP44;PDP2
Regulation of pyruvate dehydrogenase (PDH) complexPDK2B;PDK3B;PDK3;PDP1;PDK4;PDPR;PDK2;PDP2
The citric acid (TCA) cycle and respiratory electron transportFAM36A;TIMMDC1;SLC25A14;NDUFAF4;C20orf7;LRPPRC;SCO1;NDUFAF6;D2HGDH

PDP1 has several biochemical functions, for example, [pyruvate dehydrogenase (lipoamide)] phosphatase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDP1 itself. We selected most functions PDP1 had, and list some proteins which have the same functions with PDP1. You can find most of the proteins on our site.

Function Related Protein
[pyruvate dehydrogenase (lipoamide)] phosphatase activityPDP2;PDP1
metal ion bindingZNF576;POLR3B;PRKCHA;ZNF223;PRMT3;ZNF726;PRR3;ZNF485;KIT
protein bindingGTPBP2;LRRC4C;KPNA2;SYCE2;RNF165;MIS18A;PROC;SMARCD1;JAK2
protein serine/threonine phosphatase activityPPP2R2A;PPP3CB;PPM1AA;PPP4C;PPM1B;PPM1G;UBLCP1;PPM1BA;CDC14AB

PDP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDP1.

CBFA2T2; PDHA1; yiuR; SIRT4

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