Recombinant Human PDP1, His-tagged

• Cat.No.: PDP1-698H
• Product Overview: Recombinant Human PDP1 with a His tag is expressed inBacteriaand column-purified.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: PDH kinases (PDK"s) deactivate PDH by reversible phosphorylation. In humans and rodents, 4 PDK"s are present in an organ-dependent manner. In all cases, PDK"s are physically part of the PDH complex (binding via lipoyl domain 2 of E2), and they phosphorylate the E1 subunit at 3 specific serine residues. PDH phosphatases remove the phosphorylation and restore activity of PDH.
• Storage: Store at -80°C.

Gene Information

• Gene Name: PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 [ Homo sapiens ]
• Synonyms: PDP1; pyruvate dehyrogenase phosphatase catalytic subunit 1; PDP 1; PDPC 1; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; protein phosphatase 2C, magnesium-dependent, catalytic subunit; pyruvate dehydrogenase (Lipoamide) phosphatase-phosphatase; pyruvate dehydrogenase phosphatase catalytic subunit 1; PDH; PDP; PDPC; PPM2C; FLJ32517; FLJ56179; MGC119646; EC 3.1.3.43
• Gene ID: 54704
• mRNA Refseq: NM_001161778
• Protein Refseq: NP_001155250
• MIM: 605993
• UniProt ID: Q9P0J1
• Chromosome Location: 8q22.1
• Pathway: Integration of energy metabolism; Pyruvate metabolism and Citric Acid (TCA) cycle
• Function: [pyruvate dehydrogenase (lipoamide)] phosphatase activity; calcium ion binding; hydrolase activity; magnesium-dependent protein serine/threonine phosphatase activity; protein complex binding