PDPK1
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Official Full Name
3-phosphoinositide dependent protein kinase-1
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Overview
A hallmark of signal transduction pathways is the reversible phosphorylation of serine and threonine residues within specific sequences, or motifs, in target proteins. Specific signaling motifs include not only sequences that are recognized by protein kin -
Synonyms
PDPK1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; PDK1; PkB kinase; PkB-like 1; PkB kinase like gene 1; PRO0461; MGC20087; MGC35290;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
PDPK1 involved in several pathways and played different roles in them. We selected most pathways PDPK1 participated on our site, such as PPAR signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PPAR signaling pathway | PDPK1B;ILK;ACOX2;CYP4A14;ACSL4;CYP4A10;ACSL1A;CYP27A1;RXRGB |
| FoxO signaling pathway | GADD45AB;CCND2A;SGK2A;GABARAPA;PLK1;CCND2;MAPK14B;PRKAG3;CCND1 |
| Sphingolipid signaling pathway | S1PR4;PIK3R2;ACER1;SPTLC1;PTEN;PIK3R3;TRADD;AKT2;MAPK10 |
| mTOR signaling pathway | RRAGCA;IGF1;PIK3R3A;PIK3R1;EIF4EA;AKT1S1;RPS6KAL;MTOR;PRKCG |
| PIK-Akt signaling pathway | HRAS;CCND1;GNG4;FGF10;PIK3CA;PIK3CG;LAMB4;PPP2R5B;INSR |
| AMPK signaling pathway | PPP2R5C;LEP;AKT1;PPP2R3A;CFTR;PPARG;PIK3CD;RHEB;CREB3 |
| Focal adhesion | PIK3CB;RHOAC;PPP1CA;LAMA3;MAPK4;THBS4;CAV2;VWF;Reln |
| T cell receptor signaling pathway | PIK3R5;LCK;NFATC2;PIK3CD;CDC42;PIK3CB;NRAS;NFATC3;GRAP2 |
| Fc epsilon RI signaling pathway | PIK3R5;LYN;KRAS;PLA2G4A;FYN;MAPK9;PIK3CD;PDPK1;IL5 |
| Neurotrophin signaling pathway | MAPK13;KRAS;PRDM4;NRAS;PIK3R5;PLCG2;NTRK1;NFKBIA;CAMK2A |
| Insulin signaling pathway | PPP1CB;MAPK10;PRKAG1;PRKACA;PPP1R3DA;FLOT2;PIK3R1;EIF4E1B;INSRB |
| Thyroid hormone signaling pathway | GATA4;PLCB2;NOTCH2;TRP53;HRAS;PIK3R5;WNT4;PDPK1;GSK3B |
| Insulin resistance | PRKAB1A;PIK3CB;CREB3L2;PIK3CA;PRKAB1;GYS1;PPARAB;PRKCB;STAT3 |
| Aldosterone-regulated sodium reabsorption | ATP1A3;INS;HSD11B2;ATP1A4;PIK3R1;PIK3R5;FXYD4;INS1;KCNJ1 |
| Toxoplasmosis | SOCS1;AKT2;BCL2L1;Toxoplasma Gondii Microneme Protein MIC3;IL10RA;LAMB2;MAP2K6;LAMC2;HLA-DQA1 |
| Hepatitis C | OAS1A;EIF2AK4;IFNA14;PPP2R1A;IFNA21;IFNA13;SOS1;BRAF;MAPK8 |
| Proteoglycans in cancer | DDX5;ITPR3;CAMK2G;PLAUR;CDC42;FZD6;PTCH1;PIK3CB;SRC |
| Endometrial cancer | ERBB2;TRP53;CTNNA2;PIK3CA;MAPK3;BRAF;MLH1;RAF1;TCF7 |
| Prostate cancer | PIK3CD;TCF7;RAF1;IGF1R;PIK3CB;GSTP1;PDGFC;NOXA1;GSK3B |
| Non-small cell lung cancer | FHIT;FOXO3;PIK3R5;RXRG;TGFA;MAP2K2;CASP9;RARB;MAP2K1 |
| Choline metabolism in cancer | PPAP2C;PIK3R2;RAC2;PDGFB;PLA2G4F;DGKQ;GPCPD1;PLCG1;WASL |
PDPK1 has several biochemical functions, for example, 3-phosphoinositide-dependent protein kinase activity, ATP binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDPK1 itself. We selected most functions PDPK1 had, and list some proteins which have the same functions with PDPK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3-phosphoinositide-dependent protein kinase activity | ALPK2;PDPK1 |
| ATP binding | MARK4;AACS;STRC;STK11;KIF4;ABCA8;SLC27A2;GK;AURKB |
| insulin receptor binding | DOK1B;FRS3;ENPP1;PDPK1;IRS4;FRS2;SHC1;FRS2B;IRS2 |
| phospholipase activator activity | CCL3;GM2A;CCL8;PDPK1;APOC2;CCL5;ARHGAP6 |
| phospholipase binding | SNCA;PTPN11;PRKCZ;CALM1;DGKQ;Pla2r1;NEFL;CALM2;ARHGAP6 |
| protein binding | ATF4;KAT7;CREB3L3;SNRPA;CDH1;HSPB11;MMP20;GLS;LTBP1 |
| protein kinase binding | NR4A3;CD4;SLC12A4;CYLD;CCNL1;HDAC4;ADAM10;SREBF1;CDKN2B |
| protein serine/threonine kinase activity | ERN2;MAP3K4;TSSK6;CSNK1A1;SIK2;PIK3R4;ROCK1;PAK7;CSNK2A1 |
PDPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDPK1.
AKT1; YWHAQ; PPP2R2B; APBB3; CSK; SGK1; PTPRC
Research Area
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