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  • Official Full Name

    3-phosphoinositide dependent protein kinase-1

  • Overview

    A hallmark of signal transduction pathways is the reversible phosphorylation of serine and threonine residues within specific sequences, or motifs, in target proteins. Specific signaling motifs include not only sequences that are recognized by protein kin
  • Synonyms

    PDPK1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; PDK1; PkB kinase; PkB-like 1; PkB kinase like gene 1; PRO0461; MGC20087; MGC35290;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDPK1-387H Active Recombinant Human PDPK1, His-tagged Sf9 Insect Cell His
Human PDPK1-1891H Recombinant Human 3-Phosphoinositide Dependent Protein Kinase-1, His-tagged Insect Cell His
Human PDPK1-561H Active Recombinant Human PDPK1, GST-tagged Sf9 Insect Cell GST
Human PDPK1-1626H Recombinant Human PDPK1, His-tagged E.coli His 198-556aa
Human PDPK1-3321HCL Recombinant Human PDPK1 293 Cell Lysate HEK293 N/A
Human PDPK1-3322HCL Recombinant Human PDPK1 293 Cell Lysate HEK293 N/A
Human PDPK1-4825H Recombinant Human PDPK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PDPK1-1077H Recombinant Human PDPK1 Protein (M51-A360), His tagged Insect Cell His M51-A360
Human PDPK1-1076H Recombinant Human PDPK1 Protein (M51-A360), Tag Free Insect Cell No tag M51-A360
Human PDPK1-448H Recombinant Human PDPK1 Protein, His-tagged E.coli His Lys83~Ala338
Human PDPK1-3162H Recombinant Human PDPK1 Protein (Lys83-Ala338), His tagged E.coli His Lys83-Ala338
Human PDPK1-1866H Recombinant Human PDPK1 protein, GST-tagged E.coli GST 198-556 aa
Human PDPK1-2434HF Active Recombinant Full Length Human PDPK1 Protein, GST-tagged Insect (sf21) GST 1-556(end)
Mouse Pdpk1-4777M Recombinant Mouse Pdpk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PDPK1-4357R Recombinant Rat PDPK1 Protein Mammalian Cell His
Rat PDPK1-4017R Recombinant Rat PDPK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PDPK1-4017R-B Recombinant Rat PDPK1 Protein Pre-coupled Magnetic Beads HEK293
Chicken PDPK1-1904C Recombinant Chicken PDPK1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PDPK1 Related Articles
  • PDPK1 Related Research Area

PDPK1 involved in several pathways and played different roles in them. We selected most pathways PDPK1 participated on our site, such as PPAR signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Sphingolipid signaling pathwayABCC1;PPP2R5C;ROCK2;SMPD2;SMPD1;PLCB1;GNAI1;NFKB1;GNAQ
PIK-Akt signaling pathwayTHBS2;PDGFRA;GNG13;IFNB1;MCL1;HSP90AA1;PPP2R5B;LAMA5;G6PC3
AMPK signaling pathwayIGF1;G6PC3;TBC1D1;INS1;RAB10;RAB14;PDPK1;PRKAG2;PPP2CB
T cell receptor signaling pathwayLCK;MAPK11;PPP3CA;SLA1;AKT1;MAPK1;TEC;PAK6;VAV2
Fc epsilon RI signaling pathwayMAPK11;INPP5D;LAT;BTK;PLA2G4F;IL3;MAPK12;PLA2G4D;PIK3R5
Neurotrophin signaling pathwayNFKBIA;MAPK8;PIK3R1;IRAK4;IRAK1;CALM1;MAP2K2;CALM3;CALM4
Insulin signaling pathwayIRS1;HKDC1;PPP1CC;SREBF1;PIK3CD;EIF4E2RS1;RPS6;INS2;PRKAG2A
Thyroid hormone signaling pathwayPRKCG;AKT1;PRKCB;MDM2;KAT2B;RXRG;STAT1;PLCB3;MED13L
Aldosterone-regulated sodium reabsorptionKCNJ1;ALPHA-ENAC;HSD11B2;ATP1B2;ATP1B3;PRKCG;SLC9A3R2;FXYD4;SFN
ToxoplasmosisMAPK3;BIRC2;PIK3CA;IL10RB;PDPK1;HLA-DMB;LAMA2;Toxoplasma Gondii Profilin Family Protein;PIK3R5
Proteoglycans in cancerCAV3;SMO;PPP1CC;THBS1;HIF1A;Casp3;WNT9A;CBLB;PIK3CA
Endometrial cancerTCF7L2;TP53;FOXO3;RAF1;HRAS;PDPK1;CCND1;PIK3R2;APC2
Non-small cell lung cancerFOXO3;PRKCA;ALK;RXRB;PIK3CA;AKT1;RXRA;RASSF5;CASP9
Choline metabolism in cancerDGKG;SLC22A1;PLA2G4A;PPAP2B;PIK3CA;PLD2;DGKA;PDGFRA;MAP2K2

PDPK1 has several biochemical functions, for example, 3-phosphoinositide-dependent protein kinase activity, ATP binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDPK1 itself. We selected most functions PDPK1 had, and list some proteins which have the same functions with PDPK1. You can find most of the proteins on our site.

Function Related Protein
3-phosphoinositide-dependent protein kinase activityALPK2;PDPK1
insulin receptor bindingFRS2A;IRS1;PTPN1;GRB10;DOK7;FRS3;DOK1B;SNX2;IGF1R
phospholipase activator activityGM2A;ARHGAP6;APOC2;PDPK1;CCL3;CCL5;CCL8
protein bindingCFL2;TEAD2;SLC4A1A;KLHL7;ERP27;SWAP70;ITGB2;GSK3A;C4BPB
protein kinase bindingCDC42;TBC1D14;MAVS;TPRKB;DUSP3;BCL10;KIF20A;MAG;DAXX
protein serine/threonine kinase activityCSNK1A1L;ADCK2;RPS6KA3A;RPS6KA3;MAP3K12;SNRKB;PRKCZ;CDK1;DYRK1A

PDPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDPK1.


Garimella, SV; Gehlhaus, K; et al. Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. BREAST CANCER RESEARCH 16:-(2014).
Wong, VVT; Nissom, PM; et al. Zinc as an insulin replacement in hybridoma cultures. BIOTECHNOLOGY AND BIOENGINEERING 93:553-563(2006).
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