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Recombinant Human 3-Phosphoinositide Dependent Protein Kinase-1, His-tagged

Cat.No. : PDPK1-1891H
Product Overview : Recombinant humanPDPK1 was expressed in insect cells. Its molecular weight is 66900 Dalton.
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Cat. No. : PDPK1-1891H
Description : PDPK1 is aserine/threonine protein kinase localized to the plasma membrane. It plays avital role in insulin-induced glycogen synthesis, PKC activation, andactivation of the AGC subfamily of protein kinases. No special measures weretaken to activate this kinase. PDPK1 is a master kinase, which is crucial forthe activation of AKT/PKB and many other AGC kinases including PKC, S6K, SGK.An important role for PDPK1 is in the signalling pathways activated byseveral growth factors and hormones including insulin signalling.
Source : Insect cells
Species : Human
Form : Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol.
Molecular Weight : 66.9 kDa
Storage : Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : PDPK1
Gene Name : PDPK1 3-phosphoinositide dependent proteinkinase-1 [ Homo sapiens ]
Synonyms : PDPK1; 3-phosphoinositidedependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1;PDK1; PRO0461; MGC20087; MGC35290; PkB kinase; hPDK1; EC
Gene ID : 5170
mRNA Refseq : NM_002613
Protein Refseq : NP_002604
MIM : 605213
UniProt ID : O15530
Chromosome Location : 16p13.3
Pathway : Activation of NMDA receptorupon glutamate binding and postsynaptic events; Activation of PKB; AdaptiveImmune System; Aldosterone-regulated sodium reabsorption; B Cell ReceptorSignaling Pathway; BCR signaling pathway; CD28 co-stimulation; CD28 dependentPI3K/Akt signaling; Class I PI3K signaling events; Costimulation by the CD28family; Focal adhesion; Hemostasis; IGF1 pathway; IRS-mediated Signaling;Insulin Pathway
Function : 3-phosphoinositide-dependentprotein kinase activity; ATP binding; kinase activity; nucleotide binding;protein binding; protein serine/threonine kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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