PINK1
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Official Full Name
PTEN induced putative kinase 1
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Overview
PINK1 (PTEN-induced putative kinase 1) is a serine/threonine protein kinase that localises to mitochondria. It has been implicated in protecting cells from stress-induced mitochondrial dysfunction. Mutations in this gene are thought to be the cause of autosomal recessive early-onset Parkinson disease 6 (PARK6). -
Synonyms
PINK1; PTEN induced putative kinase 1; BRPK; PARK6; FLJ27236; Parkinson disease (autosomal recessive) 6; Serine/threonine-protein kinase PINK1, mitochondrial; PTEN-induced putative kinase protein 1; OTTHUMP00000002881; protein kinase BRPK;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- P. humanus
- Pediculus humanus corporis
- T. castaneum
- Zebrafish
- E. coli
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect cell
- Mammalian Cell
- Sf9 insect cells
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- MBP
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PINK1 Related Articles
- PINK1 Related Research Area
PINK1 involved in several pathways and played different roles in them. We selected most pathways PINK1 participated on our site, such as Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with PINK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Parkinsons disease | UBE2J2;Casp3;SLC18A2;UQCRH;NDUFA7;UQCRB;NDUFB5;ATP5J;SNCA |
PINK1 has several biochemical functions, for example, ATP binding, C3HC4-type RING finger domain binding, calcium-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PINK1 itself. We selected most functions PINK1 had, and list some proteins which have the same functions with PINK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MAPK8;DNAJA4;OASL1;ABCC8;TP53;BUB1B;TTK;MAT2AB;ZRANB3 |
| C3HC4-type RING finger domain binding | HSPA8;KCNH2;DNAJA1;HSPA1B;PINK1;HSPA1A |
| calcium-dependent protein kinase activity | |
| kinase activity | CAMK2A;PLAUB;NIM1;SBK1;FYNB;GRK1A;PRPS1L1;IGF1RA;MAP3K12 |
| magnesium ion binding | IMPA2;RPS6KAL;PI4K2A;TSSK6;SERPINB1A;GEM;SRPK2;FIGNL1;CLYBL |
| peptidase activator activity | MMP25;APP;PCOLCE;PINK1;FN1;MMP14;PCOLCE2;CAV1;CLPX |
| protease binding | ADRM1;STIM1;ALPI;SERPINA1A;TNF;ITGB3;TIMP2B;ADAM8A;HSPA6 |
| protein binding | MPHOSPH6;SLC25A5;RGS16;CCAR1;RNF19B;ATXN7L3;HMGN2;CCDC101;CDKN3 |
| protein kinase B binding | RARA;PINK1;PDE3B;CCDC88A;BAD;CDC37;ANKRD2;BCL10;APPL1 |
| protein kinase activity | PDK1;GRK7A;GRK1A;PAK1;SYK;CDC7;STK4;GM7168;STK24A |
| protein serine/threonine kinase activity | DCAMKL2;WNK1;ATM;GRK1A;CDK11B;DCLK1;ACVRL1;PKN2;TSSK4 |
| ubiquitin protein ligase binding | ARRB2;TUBB;DNAJA1;SMAD2;KCNQ3;USP13;HM13;ERLIN2;FAF1 |
PINK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PINK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PINK1.
PARK2; EED; FBXO7
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