PKD2

  • Official Full Name

    polycystic kidney disease 2 (autosomal dominant)

  • Overview

    As members of the calcium-/calmodulin-depedent protein kinase superfamily, there are three known Protein Kinase D receptor in stably-transfected AGS-B cells. Furthermore, PKD2 is found to be active during the early phase of differentation of C2C12 cells into skeletal muscle cells. It is also reported to enhance TCR-induced NFAT activity in Jurkat T cells.

  • Synonyms

    PKD2;polycystic kidney disease 2 (autosomal dominant);polycystin-2;Pc 2;PC2;PKD4;transient receptor potential cation channel;subfamily P;member 2;TRPP2;R48321;polycystwin;autosomal dominant polycystic kidney disease type II protein;transient receptor potential cation channel, subfamily P, member 2;Pc-2;APKD2;MGC138466;MGC138468

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • Zebrafish
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • Sf9 Cells
  • HEK293
  • GST
  • His
  • Non
  • Flag
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
PKD2-19H Recombinant Human PKD2 Protein, GST-tagged E.coli Human GST 682-923 aa
PKD2-12860M Recombinant Mouse PKD2 Protein Mammalian Cells Mouse His
PKD2-2812C Recombinant Chicken PKD2 Mammalian Cells Chicken His
PKD2-30689TH Recombinant Human PKD2 Wheat Germ Human Non 100 amino acids
PKD2-410H Recombinant Human PKD2, GST-tagged, Active Sf9 Cells Human GST
PKD2-459Z Recombinant Zebrafish PKD2 Mammalian Cells Zebrafish His
PKD2-660H Recombinant Human Polycystic Kidney Disease 2 (Autosomal Dominant) E.coli Human Non
PKD2-1184HFL Recombinant Human PKD2 protein, His&Flag-tagged HEK293 Human Flag&His 1-968 aa
PKD2-6779M Recombinant Mouse PKD2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
PKD2-6779M-B Recombinant Mouse PKD2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PKD2 involved in several pathways and played different roles in them. We selected most pathways PKD2 participated on our site, such as Assembly of the primary cilium,Cargo trafficking to the periciliary membrane,Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    VxPx cargo-targeting to cilium PKD1,CNGA2,CNGA5,ARF4A,ARF4,RAB3IP
    Organelle biogenesis and maintenance TCTN1,MKKS,IFT80,MTFMT,EXOC6,MRPL46,MRPS34,MRPS26,BBS5,POLRMT
    Cargo trafficking to the periciliary membrane EXOC1,PROL1,CCT2,SSTR3,RHOL,CNGA5,BBS5,CYS1,EXOC6,BBS4
    Assembly of the primary cilium CCP110,HSPB11,DYNLL2B,B9D2,CEP57,WDR34,CEP70,DCTN1,TUBB4B,TNPO1

    Protein Function

    PKD2 has several biochemical functions, for example, ATPase binding,HLH domain binding,actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PKD2 itself. We selected most functions PKD2 had, and list some proteins which have the same functions with PKD2. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding ANXA2B,CLEC3B,TLL2,SRR,ANXA1C,SDF4,MMP24,CASQ1,RAB11FIP3,LOC100686744
    protein binding KIAA1524,STRA13,CAMK2D,VIPR1,KLC4,IL24,ACMSD,TSSK2,PTGER4,CLEC4G
    actinin binding CSRP3,TTN,PDLIM5,MICALL2,RELA,NFKB1,PROM1
    ATPase binding S100A1,PTPN3,TAF9,ANK2,ATPIF1B,SLC26A9,TOR1AIP2,DRD1,ATP6V0A2B,NUFIP1
    cytoskeletal protein binding B4GALT1,EZRB,EPB41B,PTPN3,TOR1AIP1,PTPN4A,CDK5,PKD2L1,ALDOC,EZRA
    ion channel binding PACS1,KCNB1,NEDD4L,KCNB2,KCNC1,KCND3,ID2,FGF13,FXYD1,PANX1
    potassium channel activity KCNK1A,KCNG1,KCNC2,KCNIP4,KCNK9,KCNS3A,KCNK13B,KCNH6A,KCNK2B,KCNJ11L
    calcium-induced calcium release activity RYR3,RYR2
    protein homodimerization activity PLOD1,RENBP,PDGFRA,CTSE,CLIC6,CDSN,OXCT1,ADIPOQ,FZD1,PTS

    Interacting Protein

    PKD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKD2.

    PKD1;TRPC1

    Resources

    References

    • Armacki, M; Joodi, G; et al. A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis. ONCOGENE 33:1167-1180(2014).
    • Streets, AJ; Wessely, O; et al. Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation. HUMAN MOLECULAR GENETICS 22:1924-1939(2013).

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