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PKD2

Official Full Name

polycystic kidney disease 2 (autosomal dominant)
Overview

As members of the calcium-/calmodulin-depedent protein kinase superfamily, there are three known Protein Kinase D receptor in stably-transfected AGS-B cells. Furthermore, PKD2 is found to be active during the early phase of differentation of C2C12 cells into skeletal muscle cells. It is also reported to enhance TCR-induced NFAT activity in Jurkat T cells.
Synonyms

PKD2; polycystic kidney disease 2 (autosomal dominant); polycystin-2; Pc 2; PC2; PKD4; transient receptor potential cation channel; subfamily P; member 2; TRPP2; R48321; polycystwin; autosomal dominant polycystic kidney disease type II protein; transient receptor potential cation channel, subfamily P, member 2; Pc-2; APKD2; MGC138466; MGC138468;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Sf9 Insect Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Flag
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PKD2-30689TH	Recombinant Human PKD2	Wheat Germ	N/A	100 amino acids	Inquiry
Human	PKD2-660H	Recombinant Human Polycystic Kidney Disease 2 (Autosomal Dominant)	E.coli	N/A		Inquiry
Human	PKD2-410H	Recombinant Human PKD2, GST-tagged, Active	Sf9 Insect Cell	GST		Inquiry
Human	PKD2-1184HFL	Recombinant Human PKD2 protein, His&Flag-tagged	HEK293	His&Flag	1-968 aa	Inquiry
Human	PKD2-19H	Recombinant Human PKD2 Protein, GST-tagged	E.coli	GST	682-923 aa	$319 / 25ug
Mouse	PKD2-12860M	Recombinant Mouse PKD2 Protein	Mammalian Cell	His		Inquiry
Mouse	PKD2-6779M	Recombinant Mouse PKD2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PKD2-6779M-B	Recombinant Mouse PKD2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	PKD2-459Z	Recombinant Zebrafish PKD2	Mammalian Cell	His		Inquiry
Chicken	PKD2-2812C	Recombinant Chicken PKD2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PKD2 Related Articles

PKD2 involved in several pathways and played different roles in them. We selected most pathways PKD2 participated on our site, such as Assembly of the primary cilium, Cargo trafficking to the periciliary membrane, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Assembly of the primary cilium	PKD1;SSTR3;CCT4;ARL3;HDAC6;AKAP9;EXOC8;CEP57;CP110
Cargo trafficking to the periciliary membrane	ARL3;LZTFL1;BBS2;CYS1;CCT8;RHOL;CCT3;UNC119B;BBS4
Organelle biogenesis and maintenance	MRPL55;MRPS23;TRIP11;MRPL48;DYNLRB1;MRPS35;TCTN3;PROL1;CC2D2A
VxPx cargo-targeting to cilium	PKD2;PKD1;ARF4A;CNGA5;RAB3IP;CNGA2;ARF4

PKD2 has several biochemical functions, for example, ATPase binding, HLH domain binding, actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PKD2 itself. We selected most functions PKD2 had, and list some proteins which have the same functions with PKD2. You can find most of the proteins on our site.

Function	Related Protein
ATPase binding	ALDOB;SLC26A9;FXYD1;Ar;GRIN2A;ATP1B2;ATXN3;WFS1;DNAJB1
HLH domain binding	SIRT1;UBE2I;PKD2
actinin binding	PKD2;TTN;CSRP3;MICALL2;RELA;NFKB1;PROM1;PDLIM5
calcium ion binding	CRB2B;PPEF1;EGFL7;EGF;TC2N;PLA2G10;BMP1B;PPP3CB;SPOCK2
calcium-induced calcium release activity	RYR3;PKD2;RYR2
cytoskeletal protein binding	EPB41L5;NEBL;MYLIP;ANXA2A;SLC8A1;ANXA2B;RPH3AL;EPB41L4A;EPB41B
identical protein binding	UBQLN1;ZNF703;PSME3;MRFAP1L1;MICU1;FTL;SHANK1;MUL1A;ATL3
ion channel binding	USP10;LYN;KCND3;FKBP1A;AP2M1;PHPT1;PRKCSH;SLC14A2;KCNB1
muscle alpha-actinin binding	LDB3;PKD2L1;PALLD;MYPN;PKD2;PDLIM2;TTN;NRAP
phosphoprotein binding	CBX4;PIH1D1;PKD2;PLAT;TBL2;SERPINB1A;SFN;TBK1;THRAP3
potassium channel activity	KCNK13A;KCNS3B;KCNK18;TRPM5;KCNK15;KCNK1;KCNQ2;AQP1;KCNC3A
protein binding	GH1;MIER1;APEH;CAMSAP1L1;PTPRM;ZNF114;DPM1;EPB41L1;CCNB3
protein homodimerization activity	CRYBB2;TYW5;NPR3;LGALS6;TMEM192;MSH2;STOM;ADRB3;XBP1
receptor binding	P2RX4;ABCA1;HLA-E;FGF10B;MAG;TYROBP;CAV1;TENM2;NPFFL
voltage-gated calcium channel activity	CACNA1SB;PKD2;CACNB2;NALCN;CACNG6;CACNG8;TMC1;CATSPER1;GAS6
voltage-gated cation channel activity	GRIN1;GRIK1;GRIN2A;PKD2;HVCN1
voltage-gated ion channel activity	ANO6;KCNIP4;SCN4AB;KCNC3B;CATSPER2;KCNJ11L;CACNA1SA;CLIC6;CACNA1C
voltage-gated sodium channel activity	SCN3B;SCN4AA;SCN5A;SCN12AA;ASIC4A;SCN8A;SCN1LAB;SCN4A;SCN8AB

PKD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKD2.

PKD1; TRPC1

Armacki, M; Joodi, G; et al. A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis. ONCOGENE 33:1167-1180(2014).

Streets, AJ; Wessely, O; et al. Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation. HUMAN MOLECULAR GENETICS 22:1924-1939(2013).