PKP1
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Official Full Name
plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) -
Overview
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
B6P;PKP1;MGC138829;Plakophilin 1
Recombinant Proteins
- Mouse
- Human
- Mammalian Cells
- E.coli
- HEK293
- His
- GST
- Non
- DDK
- Myc
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PKP1-12878M | Recombinant Mouse PKP1 Protein | Mammalian Cells | Mouse | His |
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| PKP1-1975H | Recombinant Human PKP1 protein, His & GST-tagged | E.coli | Human | GST&His | Asn500~Asn742 |
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| PKP1-1365HCL | Recombinant Human PKP1 cell lysate | Human | Non |
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| PKP1-1882H | Recombinant Human PKP1 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| Pkp1-1943M | Recombinant Mouse Pkp1 Protein, His-tagged | E.coli | Mouse | His | Asn630-Phe728 |
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| Pkp1-4891M | Recombinant Mouse Pkp1 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| PKP1-4919H | Recombinant Human PKP1 Protein (Asn500-Asn742), N-GST tagged | E.coli | Human | GST | Asn500-Asn742 |
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| PKP1-6791M | Recombinant Mouse PKP1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| PKP1-6791M-B | Recombinant Mouse PKP1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| PKP1-719H | Recombinant Human PKP1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
PKP1 involved in several pathways and played different roles in them. We selected most pathways PKP1 participated on our site, such as Apoptosis,Apoptotic cleavage of cell adhesion proteins,Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptotic cleavage of cell adhesion proteins | OCLN,DSG1,DSG3,DSP,CTNNB1,DSG2,PTBP3,CTNNB2 |
| Apoptosis | IL1B,IRAK4,RNF8,E2F1,HELLS,PIK3CD,AKT3A,NFKBIA,CYCS,CTNNB1 |
| Programmed Cell Death | VIML,MLKL,CASP6L1,DNM1L,DAPK3,GAS2,DIABLOB,SATB1,DBNLB,BMX |
| Apoptotic execution phase | HIST1H1A,CASP6L2,PLECA,CTNNB2,DSG3,PANK1A,DSP,SATB1,LMNB1,STK24B |
| Apoptotic cleavage of cellular proteins | CTNNB1,DBNL,PLEC,CASP8L1,OCLN,DSP,CASP6L1,BCAP31,SATB1,LMNB1 |
Protein Function
PKP1 has several biochemical functions, for example, intermediate filament binding,lamin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PKP1 itself. We selected most functions PKP1 had, and list some proteins which have the same functions with PKP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lamin binding | LBR,TMPO,BNIP3L,PPP4C,TMEM201,TOR1AIP1,IFI27,SUN2,PLCB1,SYNE1 |
| structural constituent of epidermis | KRT36,KRT84,LOR |
| intermediate filament binding | EVPL,NME2,SYNM,NES,PKP2,EVPLA,MTM1 |
| protein binding | LPA,U2AF1,RPP25,PLD2,RTN2,ABHD16A,DHX32,FSTL5,C4orf26,MTMR7 |
| signal transducer activity | MRGPRB3,PLCB3,EMR4,GNAI2B,GNAI2,PPP1R12A,TAAR19P,GNG4,AVP,VMN1R50 |
Interacting Protein
PKP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKP1.
TNS2;USP1;GOSR1;WIPI1;GABARAPL2;GABARAPL1
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References
- Muhmer, M; Ditthardt, D; et al. An alternative promoter of the human plakophilin-3 gene controls the expression of the new isoform PKP3b. CELL AND TISSUE RESEARCH 355:143-162(2014).
- Hofmann, I; Casella, M; et al. Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules. MOLECULAR BIOLOGY OF THE CELL 17:1388-1398(2006).
