| Description : |
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
80.5 kDa |
| AA Sequence : |
MNHSPLKTALAYECFQDQDNSTLAL PSDQKMKTGTSGRQRVQEQVMMTVK RQKSKSSQSSTLSHSNRGSMYDGLA DNYNYGTTSRSSYYSKFQAGNGSWG YPIYNGTLKREPDNRRFSSYSQMEN WSRHYPRGSCNTTGAGSDICFMQKI KASRSEPDLYCDPRGTLRKGTLGSK GQKTTQNRYSFYSTCSGQKAIKKCP VRPPSCASKQDPVYIPPISCNKDLS FGHSRASSKICSEDIECSGLTIPKA VQYLSSQDEKYQAIGAYYIQHTCFQ DESAKQQVYQLGGICKLVDLLRSPN QNVQQAAAGALRNLVFRSTTNKLET RRQNGIREAVSLLRRTGNAEIQKQL TGLLWNLSSTDELKEELIADALPVL ADRVIIPFSGWCDGNSNMSREVVDP EVFFNATGCLRNLSSADAGRQTMRN YSGLIDSLMAYVQNCVAASRCDDKS VENCMCVLHNLSYRLDAEVPTRYRQ LEYNARNAYTEKSSTGCFSNKSDKM MNNNYDCPLPEEETNPKGSGWLYHS DAIRTYLNLMGKSKKDATLEACAGA LQNLTASKGLMSSGMSQLIGLKEKG LPQIARLLQSGNSDVVRSGASLLSN MSRHPLLHRVMGNQVFPEVTRLLTS HTGNTSNSEDILSSACYTVRNLMAS QPQLAKQYFSSSMLNNIINLCRSSA SPKAAEAARLLLSDMWSSKELQGVL RQQGFDRNMLGTLAGANSLRNFTSR FTRTRPLEQKLISEEDLAANDILDY KDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
