POLD1
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Official Full Name
polymerase (DNA directed), delta 1, catalytic subunit 125kDa -
Overview
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase;and 3 to 5 exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced;transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of;chromosome 6. -
Synonyms
POLD1;polymerase (DNA directed), delta 1, catalytic subunit 125kDa;POLD, polymerase (DNA directed), delta 1, catalytic subunit (125kD);DNA polymerase delta catalytic subunit;CDC2;CDC2 homolog (S. cerevisiae);CDC2 homolog;DNA polymerase subunit del
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Rat
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
POLD1 involved in several pathways and played different roles in them. We selected most pathways POLD1 participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | POLE3,WNT8B,WNT7A,MRAS,CCND3,HLA-DQB1,FDPS,TGFB2,HLA-G,SMAD2 |
| DNA Replication | MCM4,RFC2,GINS1,LIG1,MCM10,RNASEH2A,POLA2,SSBP1,DNA2,RNASEH1 |
| Nucleotide Excision Repair | POLE2,POLD4,INO80,GTF2H2C_2,GTF2H1,GTF2H2,COPS4,CUL4B,RFC4,RAD23AB |
| Metabolic pathways | CKMT1A,POLR2K,ATP6V0C,CELL,DUT,GANC,OGDHA,ATP5D,CDO1,PSPH |
| Purine metabolism | PDE6G,PDE7A,HDDC3,NME2B.1,NT5C3B,PKM2,ADPRM,ALLC,NTPCR,NUDT9 |
| Homologous recombination | MUS81,RPA2,NBN,BLM,SYCP3,RPA4,XRCC2,RAD51,POLD2,RAD51L3 |
| Pyrimidine metabolism | POLR2A,TXNRD1,NME2,NT5C1A,ENTPD6,POLR2B,NT5C1B,NT5C3L,NT5C3B,POLA1 |
| Base excision repair | UNG,APEX2,HMGB1B,POLD2,POLD3,xthA,OGG1,POLE4,NEIL2,MUTYH |
| Mismatch repair | RPA4,RPA2,RPA3,RFC3,PCNA,SSBP1,RPA1,RFC2,RFC4,MSH3 |
Protein Function
POLD1 has several biochemical functions, for example, 3-5-exodeoxyribonuclease activity,4 iron, 4 sulfur cluster binding,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLD1 itself. We selected most functions POLD1 had, and list some proteins which have the same functions with POLD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 4 iron, 4 sulfur cluster binding | NDUFS1,DDX11,ISCA2,NFU1,NTHL1,MUTYH,NDUFS8,DEM1,IREB2,RTEL1 |
| metal ion binding | GMPR2,Adamts19,KIN,ITPA,SFTPBB,TRIM50,WDFY2,MOXD1L,ZFP628,ATP13A4 |
| damaged DNA binding | OGG1,POLK,RPS3,RUVBL2,TRPC2,RPA3,FEN1,XPA,CRY2,XRCC6 |
| DNA-directed DNA polymerase activity | POLD3,CCDC111,POLG,POLE,POLD2,POLA2,POLI,POLK,POLL,DNTT |
| 3-5-exodeoxyribonuclease activity | TREX1,TREX2 |
| protein binding | RYR2,KCTD1,HIST1H1A,CALCOCO1,RNF175,TEKT1,EDA2R,VSTM2L,RPSA,RXFP4 |
| DNA binding | FOXA2,ZIM3,POU6F1,NKX2-6,HIF1AL2,TCEA1,DLX6A,STAT3,KDM5BB,RX2 |
| chromatin binding | NFATC2,TMPOA,MCMBP,ZFP143,ARX,NCOA1,UPF1,NOC3L,RAG2,EP300 |
| nucleotide binding | CPEB4,ABCA9,TRA2A,TDRD9,MAP2K4B,RBM34,PPARGC1B,RBM4.2,U2AF1L4,PAK2A |
Interacting Protein
POLD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLD1.
POLD4;POLD2
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