PPM1B
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Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent, 1B
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Overview
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. -
Synonyms
PPM1B; protein phosphatase, Mg2+/Mn2+ dependent, 1B; protein phosphatase 1B (formerly 2C), magnesium dependent, beta isoform; protein phosphatase 1B; PP2CB; PP2CBETA; PPC2BETAX; protein phosphatase 2C; beta isoform; PP2C-beta; protein phosphatase 2C isofo;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PPM1B Related Research Area
PPM1B involved in several pathways and played different roles in them. We selected most pathways PPM1B participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPM1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MAP3K6;CACNB3;MECOM;PPM1NB;CACNG6;RELB;MKNK2A;CACNA1D;MAPK14A |
PPM1B has several biochemical functions, for example, magnesium ion binding, manganese ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPM1B itself. We selected most functions PPM1B had, and list some proteins which have the same functions with PPM1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| magnesium ion binding | PRPS1L1;ENO1B;GEM;FOXK2;NEK6;ATP8B5;RPS6KA3B;CIB3;EPHX2 |
| manganese ion binding | PPM1NB;PAPOLA;WRN;PPM1AB;XPNPEP3;B4GALT1;PRIMPOL;LARGE;ARG1 |
| protein binding | DOK1;RPL10;AKAP8L;NECAB2;FEM1B;BAX;SOX10;E4F1;HOXB6 |
| protein serine/threonine phosphatase activity | CTDNEP1;PPM1BB;PPP4C;PPP6C;CDC14C;CDC14A;PPP3CA;TAB1;PPM1BA |
PPM1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPM1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PPM1B.
ARRB2; ISG15; ARRB1; Tcr-alpha; Smurf2; CHUK; RASGRP1; FOS; ANXA1; S100A8; KRT18; GSN; ANXA2
- Q&As
- Reviews
Q&As (7)
Ask a questionIts expression and activity are regulated transcriptionally, post-transcriptionally, and post-translationally.
It mitigates stress by negatively regulating stress-activated protein kinases.
PPM1B participates in p53 signaling, Wnt signaling, and the TGF-beta pathway.
It regulates multiple proteins, affecting their stability, localization, and function.
PPM1B dephosphorylates various substrates, influencing growth, development, and stress responses.
PPM1B is involved in cell cycle progression.
PPM1B dysregulation is linked to diseases like cancer, and therapeutic strategies may include modulating its expression or activity.
Customer Reviews (3)
Write a reviewPerfect for my needs.
Reliable and high quality.
Good for protein experiments.
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