PPM1B

  • Official Full Name

    protein phosphatase, Mg2+/Mn2+ dependent, 1B

  • Overview

    The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.
  • Synonyms

    PPM1B; protein phosphatase, Mg2+/Mn2+ dependent, 1B; protein phosphatase 1B (formerly 2C), magnesium dependent, beta isoform; protein phosphatase 1B; PP2CB; PP2CBETA; PPC2BETAX; protein phosphatase 2C; beta isoform; PP2C-beta; protein phosphatase 2C isofo;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PPM1B-1894H Recombinant Human PPM1B, GST-tagged E.coli GST 1-192aa
Human PPM1B-79H Recombinant Human PPM1B protein, His-tagged E.coli His 494aa(including fusion tag)
Human PPM1B-2962HCL Recombinant Human PPM1B 293 Cell Lysate HEK293 N/A
Human PPM1B-2963HCL Recombinant Human PPM1B 293 Cell Lysate HEK293 N/A
Human PPM1B-508H Recombinant Human PPM1B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PPM1B-2868H Recombinant Human PPM1B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PPM1B-3365H Recombinant Human PPM1B protein, His-SUMO-tagged E.coli His-SUMO 2-192aa
Rhesus Macaque PPM1B-3552R Recombinant Rhesus monkey PPM1B Protein, His-tagged Mammalian Cell His
Rhesus Macaque PPM1B-3370R Recombinant Rhesus Macaque PPM1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PPM1B-3370R-B Recombinant Rhesus Macaque PPM1B Protein Pre-coupled Magnetic Beads HEK293
Chicken PPM1B-2732C Recombinant Chicken PPM1B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PPM1B involved in several pathways and played different roles in them. We selected most pathways PPM1B participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPM1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPAK1;HSPA1L;HSPA1A;NFKB1;MAP3K14;FGFR3;FGF17;FGF13B;PPM1B

PPM1B has several biochemical functions, for example, magnesium ion binding, manganese ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPM1B itself. We selected most functions PPM1B had, and list some proteins which have the same functions with PPM1B. You can find most of the proteins on our site.

Function Related Protein
magnesium ion bindingWRN;STK11;FARS2;ENOPH1;PKM2;PRPS1;NLK;ENO1B;TREX2
manganese ion bindingABL1;WRN;PPM1A;NUDT7;XPNPEP1;DYRK2;IMPA1;PPM1NB;PPM1AA
protein bindingSIX3;CDC7;SNX11;SPHK1;NMNAT1;PLXDC1;TLR3;PARD3;ELMO3
protein serine/threonine phosphatase activityPPP6C;TAB1;ILKAP;PPP1CC;DUSP23B;PP2D1;PPA2;CDC14B;PDP1

PPM1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPM1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PPM1B.

ARRB2; ISG15; ARRB1; Tcr-alpha; Smurf2; CHUK; RASGRP1; FOS; ANXA1; S100A8; KRT18; GSN; ANXA2

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How is PPM1B expression and activity controlled? 05/09/2022

Its expression and activity are regulated transcriptionally, post-transcriptionally, and post-translationally.

How does PPM1B regulate cellular stress responses? 03/12/2022

It mitigates stress by negatively regulating stress-activated protein kinases.

In which cellular pathways is PPM1B involved? 12/14/2020

PPM1B participates in p53 signaling, Wnt signaling, and the TGF-beta pathway.

What proteins does PPM1B interact with and regulate? 11/28/2020

It regulates multiple proteins, affecting their stability, localization, and function.

What are PPM1B’s primary biological functions? 05/16/2020

PPM1B dephosphorylates various substrates, influencing growth, development, and stress responses.

What is PPM1B's role in cell cycle regulation? 01/28/2020

PPM1B is involved in cell cycle progression.

What are the disease implications of PPM1B, and potential therapeutic approaches? 10/18/2019

PPM1B dysregulation is linked to diseases like cancer, and therapeutic strategies may include modulating its expression or activity.

Customer Reviews (3)

Write a review
Reviews
03/12/2022

    Perfect for my needs.

    12/14/2020

      Reliable and high quality.

      05/16/2020

        Good for protein experiments.

        Ask a Question for All PPM1B Products

        Required fields are marked with *

        My Review for All PPM1B Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends