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Recombinant Human PPM1B protein, His-tagged

Cat.No. : PPM1B-79H
Product Overview : Recombinant Human PPM1B, fused with N-His tag, was expressed in E. coli.
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Description : Protein phosphatase 1B is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death.
Source : E.coli
Species : Human
Tag : His
Form : 20mM Tris.Cl, 50mM NaCl, 50% Glycerol, pH8.0.
Molecular Mass : 54.6kDa(including fusion tag)
Protein length : 494aa(including fusion tag)
Applications : WB, ELISA, IP, antibody production, protein array
Storage : Store at -80centigrade and avoid repeated freeze-thaw cycles.
Gene Name : PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B [ Homo sapiens ]
Official Symbol : PPM1B
Synonyms : PPM1B; protein phosphatase, Mg2+/Mn2+ dependent, 1B; protein phosphatase 1B (formerly 2C), magnesium dependent, beta isoform; protein phosphatase 1B; PP2CB; PP2CBETA; PPC2BETAX; protein phosphatase 2C; beta isoform; PP2C-beta; protein phosphatase 2C isoform beta; protein phosphatase 2C-like protein; protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform; PP2C-beta-X; MGC21657;
Gene ID : 5495
mRNA Refseq : NM_001033556
Protein Refseq : NP_001028728
MIM : 603770
UniProt ID : O75688
Chromosome Location : 2p22.1
Pathway : Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; ISG15 antiviral mechanism, organism-specific biosystem; Immune System, organism-specific biosystem; Interferon Signaling, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem;
Function : hydrolase activity; magnesium ion binding; manganese ion binding; protein binding; protein serine/threonine phosphatase activity; protein serine/threonine phosphatase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is PPM1B expression and activity controlled? 05/09/2022

Its expression and activity are regulated transcriptionally, post-transcriptionally, and post-translationally.

How does PPM1B regulate cellular stress responses? 03/12/2022

It mitigates stress by negatively regulating stress-activated protein kinases.

In which cellular pathways is PPM1B involved? 12/14/2020

PPM1B participates in p53 signaling, Wnt signaling, and the TGF-beta pathway.

What proteins does PPM1B interact with and regulate? 11/28/2020

It regulates multiple proteins, affecting their stability, localization, and function.

What are PPM1B’s primary biological functions? 05/16/2020

PPM1B dephosphorylates various substrates, influencing growth, development, and stress responses.

What is PPM1B's role in cell cycle regulation? 01/28/2020

PPM1B is involved in cell cycle progression.

What are the disease implications of PPM1B, and potential therapeutic approaches? 10/18/2019

PPM1B dysregulation is linked to diseases like cancer, and therapeutic strategies may include modulating its expression or activity.

Customer Reviews (3)

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Reviews
03/12/2022

    Perfect for my needs.

    12/14/2020

      Reliable and high quality.

      05/16/2020

        Good for protein experiments.

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