Recombinant Human PPM1B protein, His-tagged
Cat.No. : | PPM1B-79H |
Product Overview : | Recombinant Human PPM1B, fused with N-His tag, was expressed in E. coli. |
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- Gene Information
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Description : | Protein phosphatase 1B is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Form : | 20mM Tris.Cl, 50mM NaCl, 50% Glycerol, pH8.0. |
Molecular Mass : | 54.6kDa(including fusion tag) |
Protein length : | 494aa(including fusion tag) |
Applications : | WB, ELISA, IP, antibody production, protein array |
Storage : | Store at -80centigrade and avoid repeated freeze-thaw cycles. |
Gene Name : | PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B [ Homo sapiens ] |
Official Symbol : | PPM1B |
Synonyms : | PPM1B; protein phosphatase, Mg2+/Mn2+ dependent, 1B; protein phosphatase 1B (formerly 2C), magnesium dependent, beta isoform; protein phosphatase 1B; PP2CB; PP2CBETA; PPC2BETAX; protein phosphatase 2C; beta isoform; PP2C-beta; protein phosphatase 2C isoform beta; protein phosphatase 2C-like protein; protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform; PP2C-beta-X; MGC21657; |
Gene ID : | 5495 |
mRNA Refseq : | NM_001033556 |
Protein Refseq : | NP_001028728 |
MIM : | 603770 |
UniProt ID : | O75688 |
Chromosome Location : | 2p22.1 |
Pathway : | Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; ISG15 antiviral mechanism, organism-specific biosystem; Immune System, organism-specific biosystem; Interferon Signaling, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; |
Function : | hydrolase activity; magnesium ion binding; manganese ion binding; protein binding; protein serine/threonine phosphatase activity; protein serine/threonine phosphatase activity; |
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◆ Lysates | ||
PPM1B-2963HCL | Recombinant Human PPM1B 293 Cell Lysate | +Inquiry |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIts expression and activity are regulated transcriptionally, post-transcriptionally, and post-translationally.
It mitigates stress by negatively regulating stress-activated protein kinases.
PPM1B participates in p53 signaling, Wnt signaling, and the TGF-beta pathway.
It regulates multiple proteins, affecting their stability, localization, and function.
PPM1B dephosphorylates various substrates, influencing growth, development, and stress responses.
PPM1B is involved in cell cycle progression.
PPM1B dysregulation is linked to diseases like cancer, and therapeutic strategies may include modulating its expression or activity.
Customer Reviews (3)
Write a reviewPerfect for my needs.
Reliable and high quality.
Good for protein experiments.
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