PRDX2
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Official Full Name
peroxiredoxin 2 -
Overview
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
PRDX2;peroxiredoxin 2;TDPX1;peroxiredoxin-2;MGC4104;natural killer enhancing factor B;NKEFB;PRP;PRX2;PRXII;thiol specific antioxidant 1;thioredoxin peroxidase 1;thioredoxin dependent peroxide reductase 1;torin;TSA;NKEF-B;thiol-specific ant
Recombinant Proteins
- Human
- Mouse
- Rat
- Rhesus macaque
- Zebrafish
- Cynomolgus
- Insect Cells
- E.coli
- Human
- Mammalian Cells
- Sf9 Cells
- HEK293
- Yeast
- His
- GST
- Non
- Flag
- Avi
- Fc
- DDK
- Myc
Background
What is prdx2 protein?
Prdx2 protein, also known as peroxiredoxin 2, is an enzyme that belongs to the peroxiredoxin family. It is found in various tissues and cells, including red blood cells, liver, and lung.
Additionally, Prdx2 has been linked to several diseases. For example, dysregulation of Prdx2 expression and activity has been associated with various cancers, including colorectal cancer, lung cancer, and leukemia. It is also implicated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
What is the function of prdx2 protein?
The primary function of Prdx2 protein is to scavenge reactive oxygen species (ROS) and protect cells from oxidative stress. It accomplishes this by participating in the reduction of hydrogen peroxide and organic hydroperoxides. Prdx2 also plays a role in regulating cell signaling pathways, cell proliferation, and cell death.
Prdx2 related signaling pathway
One significant signaling pathway related to Prdx2 is the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Under conditions of oxidative stress, Nrf2 is activated and translocates to the nucleus, where it binds to antioxidant response elements (AREs) in the promoter regions of target genes, including Prdx2. This activation leads to the upregulation of Prdx2 expression, enhancing the cellular antioxidant capacity.
Prdx2 Related Diseases
In terms of related diseases, there is emerging evidence that Prdx2 dysregulation may be implicated in various pathological conditions, including cancer, neurodegenerative diseases, and cardiovascular diseases. For example, alterations in Prdx2 expression or activity have been reported in certain types of cancer, such as colorectal cancer, breast cancer, and lung cancer. Dysfunction of Prdx2 has also been associated with neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.
Biomedical Application of prdx2 Protein
Cancer research: Altered expression and activity of Prdx2 have been observed in various types of cancer. Prdx2 has been implicated in the regulation of cell proliferation, apoptosis, and metastasis. Understanding the role of Prdx2 in cancer development and progression could potentially lead to the development of novel therapeutic strategies.
Neurodegenerative diseases: Oxidative stress is a common feature of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Prdx2 plays a protective role in mitigating oxidative damage and may be involved in neuroprotection. Studying the function of Prdx2 in the context of neurodegeneration could provide insights into disease mechanisms and potential therapeutic targets.
Case Study
(Hao Su, 2017)
Fig2. ISO-induced cardiac hypertrophy is related to the expression of Trx1 and Prdx2 (A) Western blot analysis of the expressions Prdx2, Trx1 and GAPDH in H9c2 cells treated with ISO for 0, 24, 48, or 72 h. (B) Experiments were performed as in (A), and the level of Prdx2 and Trx1 was analyzed. Protein levels are relative to the control group.
(Anas Ahmad, 2022)
Fig3. Western blotting image for PRDX2 and GAPDH.
(Benhong Xu, 2021)
Fig4. ELISA validation of dysregulated proteins identified by mass spectrometry. Plasma proteins from HCs (n = 19), asymptomatic (NS, n = 24), and MS (n = 20), and severe syndrome (SS, n = 15) patients were verified by ELISA analysis.
Quality Guarantee
High Purity
Fig1. SDS-PAGE (PRDX2-2247H)
Involved Pathway
PRDX2 involved in several pathways and played different roles in them. We selected most pathways PRDX2 participated on our site, such as Cellular responses to stress,Detoxification of Reactive Oxygen Species,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional Regulation by TP53 | COX16,COX14,COX18,TACO1,SESN3,FAM36A |
| Generic Transcription Pathway | ZNF317,ZNF563,ZIM3,ZNF71,SCO1,USP9X,ESRRGA,ZNF529,ZNF266,ZNF383 |
| Cellular responses to stress | H1F0,WDR45L,HIST1H1B,HIST1H1A,RRAGA,CDKN2B,NUP35,PRDX3,MAPKAPK2B,HIF1AL |
| TP53 Regulates Metabolic Genes | COX14,LRPPRC,COX16,TACO1,SCO1,SESN3,COX18,FAM36A,SURF1 |
| Gene Expression | ZNF839,SESN3,WARS2,METTL3,PSTPIP2,RXRBB,ZNF571,RRAGB,DARS,MYBL1 |
| Selenium Pathway | TXNRD2,SERPINA3,ALOX5AP,SELK,SAA2-SAA4,TXNRD3IT1,MSRB1,SAA2,SAA4,SEP15 |
| Detoxification of Reactive Oxygen Species | TXN,PRDX3,Txn1,TXNRD2,TXN2 |
Protein Function
PRDX2 has several biochemical functions, for example, antioxidant activity,thioredoxin peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDX2 itself. We selected most functions PRDX2 had, and list some proteins which have the same functions with PRDX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| antioxidant activity | SELS,TRP53INP1,SEPW1,FABP1,UBIAD1,APOE,PRDX6,TP53INP1,KDM3B,S100A9 |
| thioredoxin peroxidase activity | PRDX4,PRDX3,PRDX1 |
Interacting Protein
PRDX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDX2.
BAD;TXN;UTY;A2M;SAT1;CA4;YWHAZ;PRDX4;IFIT5;CDC37;EXOC6;COPS5;ECSIT;RNF32;CD320;NLGN3;MAST1;ere_dna;RNASEH2A
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