PRDX2
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Official Full Name
peroxiredoxin 2
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Background
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
PRDX2; peroxiredoxin 2; TDPX1; peroxiredoxin-2; MGC4104; natural killer enhancing factor B; NKEFB; PRP; PRX2; PRXII; thiol specific antioxidant 1; thioredoxin peroxidase 1; thioredoxin dependent peroxide reductase 1; torin; TSA; NKEF-B; thiol-specific ant;
- Involved Pathway
- Protein Function
- Interacting Protein
- PRDX2 Related Research Area
PRDX2 involved in several pathways and played different roles in them. We selected most pathways PRDX2 participated on our site, such as Cellular responses to stress, Detoxification of Reactive Oxygen Species, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular responses to stress | H3F3D;WIPI2;EGLN3;MINK1;IGFBP7;H3F3B.1;TXN;ATG4A;ULK1A |
| Detoxification of Reactive Oxygen Species | TXNRD2;TXN2;PRDX3;TXN;Txn1;PRDX2 |
| Gene Expression | SAP30BP;DARS;NFIA;ZNF253;NFIC;ESRRG;MED15;ZFP36L1;TXNL4A |
| Generic Transcription Pathway | ZNF43;MED13A;ZNF461;ZNF324;ESRRG;ZNF302;MED7;MED6;SURF1 |
| Selenium Pathway | ALOX5AP;SELK;CRP;SELT;SAA2-SAA4;PRDX4;DIO2;TXNRD2;SAA4 |
| TP53 Regulates Metabolic Genes | PRDX2;COX14;SESN3;FAM36A;SCO1;TACO1;COX16;SURF1;COX18 |
| Transcriptional Regulation by TP53 | FAM36A;COX14;COX16;SESN3;COX18;TACO1;PRDX2 |
PRDX2 has several biochemical functions, for example, antioxidant activity, thioredoxin peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDX2 itself. We selected most functions PRDX2 had, and list some proteins which have the same functions with PRDX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| antioxidant activity | TP53INP1;TRP53INP1;UBIAD1;PRDX5;FAM213AA;FABP1;APOM;SELS;KDM3B |
| thioredoxin peroxidase activity | PRDX1;PRDX4;PRDX3;PRDX2 |
PRDX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDX2.
BAD; TXN; UTY; A2M; SAT1; CA4; YWHAZ; PRDX4; IFIT5; CDC37; EXOC6; COPS5; ECSIT; RNF32; CD320; NLGN3; MAST1; ere_dna; RNASEH2A
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