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  • Official Full Name

    peroxiredoxin 2

  • Overview

    This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for this gene.
  • Synonyms

    PRDX2; peroxiredoxin 2; TDPX1; peroxiredoxin-2; MGC4104; natural killer enhancing factor B; NKEFB; PRP; PRX2; PRXII; thiol specific antioxidant 1; thioredoxin peroxidase 1; thioredoxin dependent peroxide reductase 1; torin; TSA; NKEF-B; thiol-specific ant;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRDX2-1438H Active Recombinant Human Peroxiredoxin 2, His-tagged Human His
Human PRDX2-1152H Recombinant Human PRDX2, His tagged Insect Cell His
Human PRDX2-503H Recombinant Human Peroxiredoxin 2, His-tagged Sf9 Insect Cell His
Human PRDX2-142H Recombinant Human Peroxiredoxin 2 E.coli N/A
Human PRDX2-29680TH Recombinant Human PRDX2, His-tagged His
Human PRDX2-30464TH Recombinant Human PRDX2 E.coli N/A
Human PRDX2-564HCL Recombinant Human PRDX2 cell lysate Insect Cell N/A
Human PRDX2-2247H Recombinant Human PRDX2 Protein (2-198 aa), His-tagged Yeast His 2-198 aa
Human PRDX2-332H Recombinant Human PRDX2 Protein, His-tagged E.coli His Ala6~Tyr164
Human PRDX2-2910H Recombinant Human PRDX2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PRDX2-1241H Active Recombinant Human PRDX2 protein, His-tagged Insect Cells His Met1-Asn198
Human PRDX2-697H Recombinant Human PRDX2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PRDX2-2875H Recombinant Human Full length PRDX2 protein(1-198 aa), C-His-tagged E. coli C-His 1-198 aa
Human PRDX2-333H Recombinant Human PRDX2 Protein, His/GST-tagged E.coli His/GST Ala6~Tyr164
Human PRDX2-6209H Recombinant Human PRDX2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PRDX2-1758H Recombinant Human PRDX2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PRDX2-336H Recombinant Human PRDX2 protein, GST-tagged E. coli GST 1-198 aa
Human PRDX2-1758H-B Recombinant Human PRDX2 Protein Pre-coupled Magnetic Beads HEK293
Human PRDX2-4027H Recombinant Human PRDX2 protein, His-tagged E.coli His 2-198aa
Human PRDX2-1239HFL Recombinant Full Length Human PRDX2 Protein, C-Flag-tagged Mammalian cells Flag
Mouse PRDX2-13323M Recombinant Mouse PRDX2 Protein Mammalian Cell His
Mouse Prdx2-237M Active Recombinant Mouse Sncg Protein, His-tagged, Bioactivity Validated E.coli His 1-198aa
Mouse Prdx2-334H Recombinant Mouse Prdx2 Protein, His-tagged E.coli His Ala6~Tyr164
Mouse PRDX2-870M Recombinant Mouse PRDX2 Protein (Met1-Asn198), His-tagged Insect Cell His Met1-Asn198
Mouse Prdx2-5102M Recombinant Mouse Prdx2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PRDX2-7070M-B Recombinant Mouse PRDX2 Protein Pre-coupled Magnetic Beads HEK293
Mouse PRDX2-7070M Recombinant Mouse PRDX2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Prdx2-30R Recombinant Rat Prdx2 protein, His-tagged E.coli His
Rat Prdx2-335R Recombinant Rat Prdx2 Protein, His-tagged E.coli His Ala6~Tyr164
Cynomolgus Monkey PRDX2-810C Recombinant Cynomolgus PRDX2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey PRDX2-553C-B Recombinant Cynomolgus Monkey PRDX2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey PRDX2-553C Recombinant Cynomolgus Monkey PRDX2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRDX2-3590R Recombinant Rhesus monkey PRDX2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PRDX2-3408R Recombinant Rhesus Macaque PRDX2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRDX2-3408R-B Recombinant Rhesus Macaque PRDX2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PRDX2-598Z Recombinant Zebrafish PRDX2 Mammalian Cell His
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRDX2 Related Research Area

What is prdx2 protein?

Prdx2 protein, also known as peroxiredoxin 2, is an enzyme that belongs to the peroxiredoxin family. It is found in various tissues and cells, including red blood cells, liver, and lung.

Additionally, Prdx2 has been linked to several diseases. For example, dysregulation of Prdx2 expression and activity has been associated with various cancers, including colorectal cancer, lung cancer, and leukemia. It is also implicated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

What is the function of prdx2 protein?

The primary function of Prdx2 protein is to scavenge reactive oxygen species (ROS) and protect cells from oxidative stress. It accomplishes this by participating in the reduction of hydrogen peroxide and organic hydroperoxides. Prdx2 also plays a role in regulating cell signaling pathways, cell proliferation, and cell death.

Prdx2 related signaling pathway

One significant signaling pathway related to Prdx2 is the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Under conditions of oxidative stress, Nrf2 is activated and translocates to the nucleus, where it binds to antioxidant response elements (AREs) in the promoter regions of target genes, including Prdx2. This activation leads to the upregulation of Prdx2 expression, enhancing the cellular antioxidant capacity.

Prdx2 Related Diseases

In terms of related diseases, there is emerging evidence that Prdx2 dysregulation may be implicated in various pathological conditions, including cancer, neurodegenerative diseases, and cardiovascular diseases. For example, alterations in Prdx2 expression or activity have been reported in certain types of cancer, such as colorectal cancer, breast cancer, and lung cancer. Dysfunction of Prdx2 has also been associated with neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

Biomedical Application of prdx2 Protein

Cancer research: Altered expression and activity of Prdx2 have been observed in various types of cancer. Prdx2 has been implicated in the regulation of cell proliferation, apoptosis, and metastasis. Understanding the role of Prdx2 in cancer development and progression could potentially lead to the development of novel therapeutic strategies.

Neurodegenerative diseases: Oxidative stress is a common feature of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Prdx2 plays a protective role in mitigating oxidative damage and may be involved in neuroprotection. Studying the function of Prdx2 in the context of neurodegeneration could provide insights into disease mechanisms and potential therapeutic targets.

High Purity


Fig1. SDS-PAGE (PRDX2-2247H)


(Hao Su, 2017)

Fig2. ISO-induced cardiac hypertrophy is related to the expression of Trx1 and Prdx2 (A) Western blot analysis of the expressions Prdx2, Trx1 and GAPDH in H9c2 cells treated with ISO for 0, 24, 48, or 72 h. (B) Experiments were performed as in (A), and the level of Prdx2 and Trx1 was analyzed. Protein levels are relative to the control group.


(Anas Ahmad, 2022)

Fig3. Western blotting image for PRDX2 and GAPDH.


(Benhong Xu, 2021)

Fig4. ELISA validation of dysregulated proteins identified by mass spectrometry. Plasma proteins from HCs (n = 19), asymptomatic (NS, n = 24), and MS (n = 20), and severe syndrome (SS, n = 15) patients were verified by ELISA analysis.

PRDX2 involved in several pathways and played different roles in them. We selected most pathways PRDX2 participated on our site, such as Cellular responses to stress, Detoxification of Reactive Oxygen Species, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cellular responses to stressHIST2H3C;RING1;DNAJB6;EEF1A1;WIPI2;RBB4L;HMGA1;H3F3B.1;CDK6
Detoxification of Reactive Oxygen SpeciesTxn1;TXNRD2;PRDX2;TXN2;PRDX3;TXN
Gene ExpressionNR4A2B;LSM6;CTGF;ZNF561;ZNF45;TARBP2;TET2;ZNF707;ELAVL1
Generic Transcription PathwayZNF624;NR2E3;ZNF658;ESR2B;ZNF433;ZNF213;ZNF224;RARAA;ZNF225
TP53 Regulates Metabolic GenesSESN3;COX16;FAM36A;COX14;PRDX2;LRPPRC;SCO1;COX18;TACO1
Transcriptional Regulation by TP53COX16;FAM36A;TACO1;SESN3;COX18;PRDX2;COX14

PRDX2 has several biochemical functions, for example, antioxidant activity, thioredoxin peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDX2 itself. We selected most functions PRDX2 had, and list some proteins which have the same functions with PRDX2. You can find most of the proteins on our site.

Function Related Protein
antioxidant activityPRDX6;KDM3B;CAT;APOM;TRP53INP1;APOA4;FAM213AA;UBIAD1;PRDX5
thioredoxin peroxidase activityPRDX4;PRDX2;PRDX1;PRDX3

PRDX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDX2.


  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does PRDX2 contribute to the field of cancer research and treatment? 04/25/2021

PRDX2's role in maintaining cellular redox balance implicates it in cancer progression. Modulating PRDX2 levels may offer avenues for developing novel cancer therapies.

Are there any side effects associated with targeting PRDX2 for therapeutic purposes? 02/11/2021

As with any targeted therapy, potential side effects need thorough investigation. Modulating PRDX2 levels could impact normal cellular functions, and careful assessment is required.

Is there evidence supporting the use of PRDX2 as a prognostic marker in certain diseases? 08/26/2020

Some studies suggest that PRDX2 levels may have prognostic value in diseases associated with oxidative stress, providing insights into disease progression.

Can PRDX2 be a target for drug development, and what challenges might be associated with this? 03/23/2018

Yes, PRDX2 is a potential drug target, but challenges include developing specific modulators and understanding the protein's complex regulatory mechanisms.

Are there any specific diagnostic tests or biomarkers related to PRDX2 protein levels? 08/22/2017

Research suggests that altered levels of PRDX2 could serve as a biomarker in diseases associated with oxidative stress, offering potential diagnostic applications.

Customer Reviews (3)

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    I am eager to embark on this scientific journey, empowered by the high-quality PRDX2 protein and the manufacturer's unparalleled assistance.


      The manufacturer's prompt and reliable technical support serves as an invaluable resource, reinforcing my confidence in the PRDX2 protein's effectiveness and enabling smooth progress in my experiments.


        Its remarkable purity and functional attributes make it an optimal choice for my research, ensuring accurate and reliable outcomes.

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