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Recombinant Full Length Human PRDX2 Protein, C-Flag-tagged

Cat.No. : PRDX2-1239HFL
Product Overview : Recombinant Full Length Human PRDX2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
  • Specification
  • Gene Information
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Description : This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 21.7 kDa
AA Sequence : MASGNARIGKPAPDFKATAVVDGAF KEVKLSDYKGKYVVLFFYPLDFTFV CPTEIIAFSNRAEDFRKLGC EVLGVSVDSQFTHLAWINTPRKEGG LGPLNIPLLADVTRRLSEDYGVLKT DEGIAYRGLFIIDGKGVLRQ
ITVNDLPVGRSVDEALRLVQAFQYT DEHGEVCPAGWKPGSDTIKPNVDDS KEYFSKHNTRTRPLEQKLISEEDLA ANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Druggable Genome
Gene Name : PRDX2 peroxiredoxin 2 [ Homo sapiens (human) ]
Official Symbol : PRDX2
Synonyms : PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a
Gene ID : 7001
mRNA Refseq : NM_005809.6
Protein Refseq : NP_005800.3
MIM : 600538
UniProt ID : P32119

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does PRDX2 contribute to the field of cancer research and treatment? 04/25/2021

PRDX2's role in maintaining cellular redox balance implicates it in cancer progression. Modulating PRDX2 levels may offer avenues for developing novel cancer therapies.

Are there any side effects associated with targeting PRDX2 for therapeutic purposes? 02/11/2021

As with any targeted therapy, potential side effects need thorough investigation. Modulating PRDX2 levels could impact normal cellular functions, and careful assessment is required.

Is there evidence supporting the use of PRDX2 as a prognostic marker in certain diseases? 08/26/2020

Some studies suggest that PRDX2 levels may have prognostic value in diseases associated with oxidative stress, providing insights into disease progression.

Can PRDX2 be a target for drug development, and what challenges might be associated with this? 03/23/2018

Yes, PRDX2 is a potential drug target, but challenges include developing specific modulators and understanding the protein's complex regulatory mechanisms.

Are there any specific diagnostic tests or biomarkers related to PRDX2 protein levels? 08/22/2017

Research suggests that altered levels of PRDX2 could serve as a biomarker in diseases associated with oxidative stress, offering potential diagnostic applications.

Customer Reviews (3)

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Reviews
02/01/2022

    I am eager to embark on this scientific journey, empowered by the high-quality PRDX2 protein and the manufacturer's unparalleled assistance.

    12/16/2020

      The manufacturer's prompt and reliable technical support serves as an invaluable resource, reinforcing my confidence in the PRDX2 protein's effectiveness and enabling smooth progress in my experiments.

      11/01/2017

        Its remarkable purity and functional attributes make it an optimal choice for my research, ensuring accurate and reliable outcomes.

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