Active Recombinant Mouse Sncg Protein, His-tagged, Bioactivity Validated

• Cat.No.: Prdx2-237M
• Product Overview: Recombinant Mouse Sncg(1-198aa) fused with His tag at N-terminal was expressed in E. coli. Bioactivity Validated.

Specification

• Description: Prdx2, also known as peroxiredoxin-2, is a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Prdx2 may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. If Prdx2 protection is inadequate against peroxidases, the resulting protein and DNA damage may result in neurological disease such as Alzheimer's or DNA damage leading to cancer.
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 10% Glycerol, 1mM DTT
• Bio-activity: Specific activity is > 700 pmol/min/ug, Activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25C for minute.
• Molecular Mass: 24.3 kDa (222aa) Confirmed by MALDI-TOF
• Protein length: 1-198aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMASGNA QIGKSAPDFT ATAVVDGAFK EIKLSDYRGK YVVLFFYPLD FTFVCPTEII AFSDHAEDFR
  KLGCEVLGVS VDSQFTHLAW INTPRKEGGL GPLNIPLLAD VTKSLSQNYG VLKNDEGIAY RGLFIIDAKG VLRQITVNDL PVGRSVDEAL
  RLVQAFQYTD EHGEVCPAGW KPGSDTIKPN VDDSKEYFSK HN
• Purity: > 90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 1mg/ml (determined by Absorbance at 280nm)

Gene Information

• Gene Name: Prdx2 peroxiredoxin 2 [ Mus musculus ]
• Official Symbol: Prdx2
• Synonyms: PRDX2; peroxiredoxin 2; peroxiredoxin-2; Prx II-1; Calpromotin; protector protein; thioredoxin reductase; thioredoxin peroxidase 1; Trx dependent peroxide reductase 1; thiol specific antioxidant protein; thiol-specific antioxidant protein; thioredoxin dependent peroxide reductase 1; thioredoxin-dependent peroxide reductase 1; TR; PRP; TPx; TSA; TDX1; NkefB; PrxII; TPx-B; Tdpx1; Torin; Band-8; AL022839
• Gene ID: 21672
• mRNA Refseq: NM_011563
• Protein Refseq: NP_035693
• UniProt ID: Q61171

Reviews

02/01/2022

I am eager to embark on this scientific journey, empowered by the high-quality PRDX2 protein and the manufacturer's unparalleled assistance.

12/16/2020

The manufacturer's prompt and reliable technical support serves as an invaluable resource, reinforcing my confidence in the PRDX2 protein's effectiveness and enabling smooth progress in my experiments.

11/01/2017

Its remarkable purity and functional attributes make it an optimal choice for my research, ensuring accurate and reliable outcomes.

Q&As

How does PRDX2 contribute to the field of cancer research and treatment?

PRDX2's role in maintaining cellular redox balance implicates it in cancer progression. Modulating PRDX2 levels may offer avenues for developing novel cancer therapies.

Are there any side effects associated with targeting PRDX2 for therapeutic purposes?

As with any targeted therapy, potential side effects need thorough investigation. Modulating PRDX2 levels could impact normal cellular functions, and careful assessment is required.

Is there evidence supporting the use of PRDX2 as a prognostic marker in certain diseases?

Some studies suggest that PRDX2 levels may have prognostic value in diseases associated with oxidative stress, providing insights into disease progression.

Can PRDX2 be a target for drug development, and what challenges might be associated with this?

Yes, PRDX2 is a potential drug target, but challenges include developing specific modulators and understanding the protein's complex regulatory mechanisms.

Are there any specific diagnostic tests or biomarkers related to PRDX2 protein levels?

Research suggests that altered levels of PRDX2 could serve as a biomarker in diseases associated with oxidative stress, offering potential diagnostic applications.