PRDX4
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Official Full Name
peroxiredoxin 4 -
Overview
The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. -
Synonyms
PRDX4;peroxiredoxin 4;peroxiredoxin-4;AOE37 2;prx-IV;peroxiredoxin IV;antioxidant enzyme AOE372;thioredoxin peroxidase AO372;thioredoxin peroxidase (antioxidant enzyme);thioredoxin-dependent peroxide reductase A0372;PRX-4;AOE37-2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- Avi
- Fc
- Flag
- DDK
- Myc
Involved Pathway
PRDX4 involved in several pathways and played different roles in them. We selected most pathways PRDX4 participated on our site, such as Selenium Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Selenium Pathway | PRDX2,TXNRD3IT1,SEP15,CRP,DIO2,SELT,SERPINA3,SELK,ALOX5AP,PRDX3 |
Protein Function
PRDX4 has several biochemical functions, for example, protein binding,protein homodimerization activity,thioredoxin peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDX4 itself. We selected most functions PRDX4 had, and list some proteins which have the same functions with PRDX4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| thioredoxin peroxidase activity | PRDX3,PRDX1,PRDX2 |
| protein homodimerization activity | HOMER2,HNF1B,ODZ4,MAP3K10,UXS1,ASCL1,OLIG2,SLK,EEA1,APOA4 |
| protein binding | DOK6,POLR1D,KIAA1199,SNAPC3,MYL2,METAP2,ITGB1BP2,ZFP2,STAT2,DDR1 |
Interacting Protein
PRDX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDX4.
LBP;TBXA2R;NR4A1;PDIA6;P4HB;PDIA3;TXNDC5;CLIC1;MT-CO1;PLG
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