PRKACB
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Official Full Name
protein kinase, cAMP-dependent, catalytic, beta -
Overview
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed. -
Synonyms
PRKACB;protein kinase, cAMP-dependent, catalytic, beta;cAMP-dependent protein kinase catalytic subunit beta;PKACb;PKA C-beta;protein kinase A catalytic subunit beta;cAMP-dependent protein kinase catalytic beta subunit isoform 4ab;MGC9320;MG
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Sf9 Cells
- Mammalian Cells
- HEK293
- Sf21 Cells
- Yeast
- Baculovirus
- Mammalian cells
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
PRKACB involved in several pathways and played different roles in them. We selected most pathways PRKACB participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKACB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile secretion | SLCO1B2,LDLR,SLC2A1,ATP1A4,ATP1B1,ABCB11,ATP1B4,SLC22A1,EPHX1,Slc4a2 |
| Circadian entrainment | KCNJ3,GNB2,CALM4,PER2,RYR1,PLCB3,GNAS,RPS6KA5,GRIA2,GNG8 |
| Thyroid hormone synthesis | PRKCB,GPX3,PRKCG,HSPA5,ITPR1,TSHR,CREB3L3,ATP1B4,ASGR2,CREB5 |
| Parkinsons disease | NDUFC2-KCTD14,COX7A2,ATP5B,NDUFA9,NDUFB9,NDUFA13,SNCA,PARK2,NDUFS5,SDHD |
| GnRH signaling pathway | PRKACBA,HRASB,PLD1,CGNRH-R,CAMK2B1,RAF1B,PRKCB,ADCY1B,RAF1,MAPK8A |
| Platelet activation | RAP1A,VWF,PLA2G4F,FCGR2A,PPP1CC,PPP1CA,GP9,PLA2G4C,LYN,ARHGEF12 |
| Prion diseases | LOC100033925,IL6,NOTCH1,C8G,ELK1,PRKACG,SOD1,MAPK1,STIP1,PRKACA |
| Proteoglycans in cancer | SMO,TGFB1,PTPN6,PIK3R3,IGF1R,MTOR,PIK3CA,SOS1,ITPR1,ESR1 |
| Dilated cardiomyopathy | CACNA2D4,MYH7,ITGB3,ITGAV,ITGA10,GNAS,TNF,ITGB7,CACNB4,ITGA5 |
Protein Function
PRKACB has several biochemical functions, for example, ATP binding,cAMP-dependent protein kinase activity,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKACB itself. We selected most functions PRKACB had, and list some proteins which have the same functions with PRKACB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ACTR8,ADCK3,LRRK1,EGFR,KIF5A,YARS2,STK31,ATPBD4,PRKDC,RUVBL1 |
| cAMP-dependent protein kinase activity | PRKX,PRKACA,PRKAG1,AKAP13,PRKAA1,PRKACG |
| ubiquitin protein ligase binding | MC1R,HDAC6,TPI1,UBE2G1,USP2,IKBKG,PRKAR2B,TMEM189,SMAD6,UCHL1 |
| protein binding | ASTE1,IL2RG,RPL19,PIGS,UQCC1,GSTO2,DPYSL5,HTR3C,HIST1H2AG,PAG1 |
| magnesium ion binding | PPM1N,CLYBL,IDH3B,TREX2,PIF1,CDC42BPA,IMPA1,DXO,NEK6,Atp8a2 |
Interacting Protein
PRKACB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKACB here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKACB.
HSP90AB1;APPBP2;AKAP5;PRKAR2B;DYNLL1;MAPRE1;FLNA;RCAN1;CBFB;PITX2;ACVR1B;RPL27A;RPS6
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References
- Han, YS; Arroyo, J; et al. Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 538:25-33(2013).
- Yang, L; Nakayama, Y; et al. GABA(C)-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220. JOURNAL OF PHARMACOLOGICAL SCIENCES 106:578-584(2008).
