PRKACB

  • Official Full Name

    protein kinase, cAMP-dependent, catalytic, beta
  • Overview

    cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms

    PRKACB;protein kinase, cAMP-dependent, catalytic, beta;cAMP-dependent protein kinase catalytic subunit beta;PKACb;PKA C-beta;protein kinase A catalytic subunit beta;cAMP-dependent protein kinase catalytic beta subunit isoform 4ab;MGC9320;MG

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Rat
  • E.coli
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • Sf21 Cells
  • Yeast
  • Baculovirus
  • Mammalian cells
  • GST
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
PRKACB-1947H Recombinant Human PRKACB, GST-tagged E.coli Human GST 1-257aa
PRKACB-553H Active Recombinant Human PRKACB, GST-tagged Sf9 Cells Human GST
PRKACB-13353M Recombinant Mouse PRKACB Protein Mammalian Cells Mouse His
PRKACB-173H Recombinant Human PRKACB, His-tagged E.coli Human His 1-398aa
PRKACB-30210TH Recombinant Human PRKACB Human Non Full L.
PRKACB-3602R Recombinant Rhesus monkey PRKACB Protein, His-tagged Mammalian Cells Rhesus macaque His
PRKACB-395H Recombinant Human PRKACB, GST-tagged, Active Sf9 Cells Human GST
PRKACB-4672R Recombinant Rat PRKACB Protein Mammalian Cells Rat His
PRKACB-2868HCL Recombinant Human PRKACB 293 Cell Lysate HEK293 Human Non
PRKACB-2407H Recombinant Human PRKACB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
PRKACB-3420R Recombinant Rhesus Macaque PRKACB Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
PRKACB-3420R-B Recombinant Rhesus Macaque PRKACB Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PRKACB-4083HF Active Recombinant Full Length Human PRKACB Protein, GST-tagged Sf21 Cells Human GST Full L. 1-351
PRKACB-4331R Recombinant Rat PRKACB Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
PRKACB-4331R-B Recombinant Rat PRKACB Protein Pre-coupled Magnetic Beads HEK293 Rat
Prkacb-4777R Recombinant Rat Prkacb protein Yeast Rat Non
Prkacb-4778R Recombinant Rat Prkacb protein E.coli Rat Non
Prkacb-4779R Recombinant Rat Prkacb protein, Avi-tagged, Biotinylated E.coli Rat Avi
Prkacb-4780R Recombinant Rat Prkacb protein Baculovirus Rat Non
Prkacb-4781R Recombinant Rat Prkacb protein Mammalian Cells Rat Non
Prkacb-5112M Recombinant Mouse Prkacb Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
Prkacb-5350M Recombinant Mouse Prkacb protein Yeast Mouse Non
Prkacb-5351M Recombinant Mouse Prkacb protein E.coli Mouse Non
Prkacb-5352M Recombinant Mouse Prkacb protein, Avi-tagged, Biotinylated E.coli Mouse Avi
Prkacb-5353M Recombinant Mouse Prkacb protein Baculovirus Mouse Non
Prkacb-5354M Recombinant Mouse Prkacb protein Mammalian cells Mouse Non
PRKACB-7087M Recombinant Mouse PRKACB Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
PRKACB-7087M-B Recombinant Mouse PRKACB Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PRKACB involved in several pathways and played different roles in them. We selected most pathways PRKACB participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKACB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis CYCS,PRKAR2B,RIPK1,IL1R1,SATB1,GZMF,BOK,IRF1B,NFKBIAA,CAPN2B
    Inflammatory mediator regulation of TRP channels PLCB2,PRKCQ,PLA2G6,TRPV3,PLCG2,MAPK12,PTGER2,PIK3CD,PLA2G4D,CYP2J6
    Serotonergic synapse HTR1F,PTGS2,CYP2C39,BRAF,CYP2C37,GNAS,GNG8,ALOX12B,ALOX15,GNG2
    Amoebiasis PRKCG,RELA,SERPINB9,ITGB2,LAMB3,COL24A1,GNAQ,SERPINB4,ACTN4,LAMB4
    Vibrio cholerae infection ATP6V0B,ATP6V1A,PRKACG,MUC2,ATP6AP1,TJP2,ACTG1,KDELR3,PDIA4,ATP6V1D
    Oxytocin signaling pathway RYR2,CAMK4,HRAS,PLA2G4F,CACNA2D3,SRC,MAP2K1,CD38,ITPR1,ELK1
    Dilated cardiomyopathy ITGA7,CACNA2D2,ITGA2B,TNF,TPM4,LAMA2,ITGB6,CACNG1,SLC8A1,TGFB1
    Bile secretion ATP1B1,CYP3A4,OSTA,SLC9A1,SLC27A5,SLC51B,SLC22A7,LDLR,ABCG2,ADCY7
    Epstein-Barr virus infection POLR2C,CR2,CD58,POLR3E,HLA-G,PSMD4,TBK1,IL10RB,SFPI1,PLCG2

    Protein Function

    PRKACB has several biochemical functions, for example, ATP binding,cAMP-dependent protein kinase activity,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKACB itself. We selected most functions PRKACB had, and list some proteins which have the same functions with PRKACB. You can find most of the proteins on our site.

    Function Related Protein
    protein binding CRYBB3,MNDA,TMEM218,MLF1IP,TMEM100,FBXO17,SPI1,CIT,RHOV,CDKN2B
    ATP binding MYO6,PFKFB1,HYOU1,ATP6V1A,ATP2B1,TTK,FUK,KIF18A,PTK2,NEK10
    ubiquitin protein ligase binding TRIOBP,BID,BLZF1,ATP6V0C,UBE2O,LTBR,PCBP2,MFN2,HSPA1L,CASP10
    magnesium ion binding CLYBL,PPM1NB,PTENB,ZNF143B,PPA1A,PIF1,ABL2,MAP3K5,SERPINB1A,ILVBL
    cAMP-dependent protein kinase activity PRKAA1,PRKACA,AKAP13,PRKX,PRKACG,PRKAG1

    Interacting Protein

    PRKACB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKACB here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKACB.

    HSP90AB1;APPBP2;AKAP5;PRKAR2B;DYNLL1;MAPRE1;FLNA;RCAN1;CBFB;PITX2;ACVR1B;RPL27A;RPS6

    Resources

    References

    • Han, YS; Arroyo, J; et al. Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 538:25-33(2013).
    • Yang, L; Nakayama, Y; et al. GABA(C)-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220. JOURNAL OF PHARMACOLOGICAL SCIENCES 106:578-584(2008).

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