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  • Official Full Name

    protein kinase C, iota

  • Overview

    This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.
  • Synonyms

    PRKCI; protein kinase C, iota; DXS1179E; protein kinase C iota type; PKCI; PRKC-lambda/iota; aPKC-lambda/iota; atypical protein kinase C-lambda/iota; nPKC-iota; MGC26534;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRKCI-151HFL Active Recombinant Full Length Human PRKCI Protein, N-His-tagged Sf21 His Full Length
Human PRKCI-28942TH Recombinant Human PRKCI N/A
Human PRKCI-757H Recombinant Human PRKCI, GST tagged Insect Cell GST
Human PRKCI-1956H Recombinant Human PRKCI, GST-tagged E.coli GST C-term-350aa
Human PRKCI-1304H Recombinant Human Protein Kinase C, Iota Sf9 Insect Cell N/A
Human PRKCI-159H Recombinant Human PRKCI protein, His-tagged E.coli His Ile375~Val596
Human PRKCI-406H Recombinant Human PRKCI, His&T7-tagged E.coli His/T7 Ile375~Val596
Human PRKCI-405H Recombinant Human Protein Kinase C, Iota, GST-tagged, Active Sf9 Insect Cell GST
Human PRKCI-1303H Recombinant Human Protein Kinase C, Iota, His-tagged Insect Cell His
Human PRKCI-2854HCL Recombinant Human PRKCI 293 Cell Lysate HEK293 N/A
Human PRKCI-5991H Recombinant Human PRKCI Protein (Ile375-Val596), His tagged E.coli His Ile375-Val596
Human PRKCI-3713H Recombinant Human PRKCI Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PRKCI-8859HF Active Recombinant Full Length Human PRKCI Protein, GST-tagged Insect (sf21) GST 1-587
Human PRKCI-01H Recombinant Human PRKCI protein, His-tagged HEK293T His 1-596aa
Mouse Prkci-5122M Recombinant Mouse Prkci Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PRKCI-4682R Recombinant Rat PRKCI Protein Mammalian Cell His
Rat PRKCI-4341R Recombinant Rat PRKCI Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PRKCI-4341R-B Recombinant Rat PRKCI Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PRKCI-9360Z Recombinant Zebrafish PRKCI Mammalian Cell His
Chicken PRKCI-2973C Recombinant Chicken PRKCI Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRKCI Related Research Area

PRKCI involved in several pathways and played different roles in them. We selected most pathways PRKCI participated on our site, such as Rap signaling pathway, Endocytosis, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKCI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayPIK3R2;PFN2;GNAS;LPAR4;FGF18;PRKD1;PRKD3;PLCE1;RALB
Hippo signaling pathwayWNT4;WNT8B;WNT3;FZD1;TCF7L2;ITGB2L;TGFB3;BMPR1A;FZD9

PRKCI has several biochemical functions, for example, ATP binding, metal ion binding, phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKCI itself. We selected most functions PRKCI had, and list some proteins which have the same functions with PRKCI. You can find most of the proteins on our site.

Function Related Protein
phospholipid bindingPSD4;NUP35;SNCA;APOA2;OSBPL1A;WDFY4;Defa4;PLA2G4C;F3
protein domain specific bindingYWHABA;GABRR3;HNRNPM;BHLHE40;FAF1;SFN;MPP5;HOMER2;PHRF1
protein kinase activityCHEK1;NEK4;COL4A3BP;SIK2A;MAPK12B;SOX9;STK25A;MAP3K4;RNASEL
protein serine/threonine kinase activitySTK32C;DCKL1B;CAMK2D1;CAMK2A;CSNK1A1;MAP2K7;ROCK2;TTBK1;PAK4

PRKCI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKCI here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKCI.


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