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Recombinant Human PRKCI Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : PRKCI-3713H
Product Overview : PRKCI MS Standard C13 and N15-labeled recombinant protein (NP_002731) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 67.3 kDa
AA Sequence : MSHTVAGGGSGDHSHQVRVKAYYRG DIMITHFEPSISFEGLCNEVRDMCS FDNEQLFTMKWIDEEGDPCTVSSQL ELEEAFRLYELNKDSELLIHVFPCV PERPGMPCPGEDKSIYRRGARRWRK LYCANGHTFQAKRFNRRAHCAICTD RIWGLGRQGYKCINCKLLVHKKCHK LVTIECGRHSLPQEPVMPMDQSSMH SDHAQTVIPYNPSSHESLDQVGEEK EAMNTRESGKASSSLGLQDFDLLRV IGRGSYAKVLLVRLKKTDRIYAMKV VKKELVNDDEDIDWVQTEKHVFEQA SNHPFLVGLHSCFQTESRLFFVIEY VNGGDLMFHMQRQRKLPEEHARFYS AEISLALNYLHERGIIYRDLKLDNV LLDSEGHIKLTDYGMCKEGLRPGDT TSTFCGTPNYIAPEILRGEDYGFSV DWWALGVLMFEMMAGRSPFDIVGSS DNPDQNTEDYLFQVILEKQIRIPRS MSVKAASVLKSFLNKDPKERLGCLP QTGFADIQGHPFFRNVDWDMMEQKQ VVPPFKPNISGEFGLDNFDSQFTNE RVQLTPDDDDIVRKIDQSEFEGFEY INPLLMSAEECVTRTRPLEQKLISE EDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : PRKCI protein kinase C iota [ Homo sapiens (human) ]
Official Symbol : PRKCI
Synonyms : PRKCI; protein kinase C, iota; DXS1179E; protein kinase C iota type; PKCI; PRKC-lambda/iota; aPKC-lambda/iota; atypical protein kinase C-lambda/iota; nPKC-iota; MGC26534;
Gene ID : 5584
mRNA Refseq : NM_002740
Protein Refseq : NP_002731
MIM : 600539
UniProt ID : P41743

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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