Recombinant Human PRKCI

Cat.No. : PRKCI-28942TH
Product Overview : Recombinant full length protein,(amino acids 2-587) of Human PKC iota/lambda, with an N terminal tag.Expressed in a Baculovirus infected Sf9 cell expression system.
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Description : This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.
Tissue specificity : Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Highly expressed in non-small cell lung cancers.
Biological activity : 35 U/ug. One unit is defined as the amount of enzyme that will phosphorylate 1 pmol of Ser/Thr 7 peptide substrate per minute at pH 7.4 and 30°C.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, 10mM reduced Glutathione, pH 8.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 OPR domain.Contains 1 phorbol-ester/DAG-type zinc finger.Contains 1 protein kinase domain.
Gene Name : PRKCI protein kinase C, iota [ Homo sapiens ]
Official Symbol : PRKCI
Synonyms : PRKCI; protein kinase C, iota; DXS1179E; protein kinase C iota type; PKCI;
Gene ID : 5584
mRNA Refseq : NM_002740
Protein Refseq : NP_002731
MIM : 600539
Uniprot ID : P41743
Chromosome Location : 3q26.3
Pathway : Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Endocytosis, organism-specific biosystem;
Function : ATP binding; metal ion binding; nucleotide binding; phospholipid binding; protein binding;

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