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  • Official Full Name

    protein kinase C, theta

  • Overview

    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
  • Synonyms

    PRKCQ; protein kinase C, theta; protein kinase C theta type; PRKCT; nPKC-theta; MGC126514; MGC141919;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Insect (sf21)
  • Insect cell
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRKCQ-152HFL Active Recombinant Full Length Human PRKCQ Protein, C-His-tagged Sf21 His Full Length
Human PRKCQ-30178TH Recombinant Human PRKCQ N/A
Human PRKCQ-916H Recombinant Human Protein Kinase C, Theta, His-tagged Insect cell His
Human PRKCQ-408H Recombinant Human Protein Kinase C, Theta, GST-tagged, Active Sf9 Insect Cell GST
Human PRKCQ-2704H Recombinant Human PRKCQ protein, His & GST-tagged E.coli His/GST Phe380~Phe634 (Accession # Q04759)
Human PRKCQ-1416HCL Recombinant Human PRKCQ cell lysate N/A
Human PRKCQ-301488H Recombinant Human PRKCQ protein, GST-tagged E.coli GST Met1-Arg145
Human PRKCQ-5515HF Active Recombinant Full Length Human PRKCQ Protein, GST-tagged Insect (sf21) GST 1-706
Human PRKCQ-3942H Recombinant Human PRKCQ protein, His-tagged E.coli His 1-145 aa
Human PRKCQ-5995H Recombinant Human PRKCQ Protein (Phe380-Phe634), N-GST tagged E.coli N-GST Phe380-Phe634
Rhesus Macaque PRKCQ-3607R Recombinant Rhesus monkey PRKCQ Protein, His-tagged Mammalian Cell His
Rhesus Macaque PRKCQ-3425R Recombinant Rhesus Macaque PRKCQ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRKCQ-3425R-B Recombinant Rhesus Macaque PRKCQ Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PRKCQ-5522Z Recombinant Zebrafish PRKCQ Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRKCQ Related Articles
  • PRKCQ Related Research Area

PRKCQ involved in several pathways and played different roles in them. We selected most pathways PRKCQ participated on our site, such as NF-kappa B signaling pathway, Vascular smooth muscle contraction, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKCQ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayBIRC2;GM10591;MAP3K14;LY96;Ccl21a;LBP;CCL4;DDX58;BCL10
Vascular smooth muscle contractionPRKCA;MAP2K2B;AVPR1A;MYL9A;MYH11;CALM;GNAQ;MAPK3;PPP1CAB
T cell receptor signaling pathwayCD3D;IL4;PTPN6;IKBKG;PPP3R2;VAV2;MAP3K7;SHB;GRAPA
Inflammatory mediator regulation of TRP channelsPIK3R3;PRKACA;BDKRB2;PRKCD;CAMK2G;PTGER2;TRPV2;MAPK8;PLCB3
Adipocytokine signaling pathwaySLC2A1;POMC;ACSL1B;JAK2A;LEP;ACSL5;LEPB;PRKAB1A;ACACB

PRKCQ has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKCQ itself. We selected most functions PRKCQ had, and list some proteins which have the same functions with PRKCQ. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingZNF83;HIC1L;PXNA;AKAP8L;COL1A1;CHSY3;RAD50;CYP8B2;Itga10&Itgb1
protein serine/threonine kinase activityRPS6KA3A;PRKCDA;AKT1;STK3;CDK15;STK19;NIM1K;ROCK2A;AAK1
ubiquitin-protein transferase activityZYG11B;MIB2;TRIM21;BIRC8;RNF20;FBXL21;ITCH;RNF144AA;CDC34

PRKCQ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKCQ here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKCQ.


Ovsyannikova, IG; Kennedy, RB; et al. Genome-wide association study of antibody response to smallpox vaccine. VACCINE 30:4182-4189(2012).
Zheng, YB; Zhang, WS; et al. Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70(S6K) activities in the liver of obese Zucker rats. JOURNAL OF ENDOCRINOLOGY 203:337-347(2009).
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