PRPS1
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Official Full Name
phosphoribosyl pyrophosphate synthetase 1 -
Overview
This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PRPS1;phosphoribosyl pyrophosphate synthetase 1;deafness, X linked 2, perceptive, congenital , DFN2;ribose-phosphate pyrophosphokinase 1;CMTX5;DFNX1;PRS I;ribose phosphate diphosphokinase 1;deafness 2, perceptive, congenital;ribose-phosphate diph
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Rat
- Cynomolgus
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- SUMO
- Avi
- Fc
- DDK
- Myc
Involved Pathway
PRPS1 involved in several pathways and played different roles in them. We selected most pathways PRPS1 participated on our site, such as Pentose phosphate pathway,Purine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | PLA2G3,PMVK,AMY2A4,ATP6V0A2,NDUFB5,AGPAT4,PGM1,NDUFA8,ACSL4A,UAP1L1 |
| Biosynthesis of amino acids | ALDOB,GOT2A,TKTL1,GPT2L,OTC,GLULC,CTH,PGAM2,PYCR1B,PFKL |
| Pentose phosphate pathway | ALDOCA,TKTL1,RGN,PGLS,FBP1A,PGM1,PGD,G6PD,ALDOAA,PGM2 |
| Carbon metabolism | DLD,SDHC,DLST,ACADS,PGLS,IDH1,ackA,PGAM1A,SUCLA2,ACAT2 |
| Purine metabolism | POLR3GL,ADSS,POLR2D,ENPP1,NT5C1AA,PDE11A,NT5C2,POLR2GL,PKMB,RRM1 |
Protein Function
PRPS1 has several biochemical functions, for example, ADP binding,AMP binding,ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPS1 itself. We selected most functions PRPS1 had, and list some proteins which have the same functions with PRPS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinase activity | RAF1A,PRKCBP1L,PRKG1A,CSNK1DA,NME2B.2,PIP5K1BA,RAF1B,CDK5,PKMB,MARCKSB |
| ADP binding | MYO6,ABCG1,PRKAG2,APAF1,MYO7A,CHORDC1,MYH9,P2RY1,GLUD2,HSP104 |
| protein binding | CRIPT,SPI1B,IGFBP3,ASL,ARHGEF40,MEOX1,MYRIP,ZFAND2B,TNS1,TAGLN2 |
| ribose phosphate diphosphokinase activity | PRPS1A,PRPS2,PRPSAP1,PRPS1L1,PRPS1B |
| magnesium ion binding | ADPRHL1,GSS,ATP9A,DUT,TREX2,RPS6KA3B,CLYBL,MTHFD2,PI4K2A,PPM1BB |
| protein homodimerization activity | CHRNA7,TOP2A,GCH1,ODZ4,FZD1,VWF,PTPRO,FASN,CADM3,TIMELESS |
| ATP binding | ACTA1A,DAPK2A,TTF2,ACSBG2,NAGK,STK10,STK4,TAOK1,CCT8,STK35L |
| GDP binding | RAB8B,RHOB,SEPT12,ARL8B,RAP2C,RAB7,RAB31,RAB18,SRP54,PIGC |
| AMP binding | PYGL,ACSS1,APRT,PRKAG1,PRPS2,PRKAG2,FBP1,CYB5R3,PYGM,ACSS2 |
Interacting Protein
PRPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPS1.
PRPS2;PRPSAP1;SPG21;GORASP2;PRPSAP2;PRPSAP1;FBXO31
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References
- Al-Maawali, A; Dupuis, L; et al. Prenatal growth restriction, retinal dystrophy, diabetes insipidus and white matter disease: expanding the spectrum of PRPS1-related disorders. EUROPEAN JOURNAL OF HUMAN GENETICS 23:310-316(2015).
- Fridman, A; Saha, A; et al. Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate. BIOCHEMICAL JOURNAL 454:91-99(2013).
