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Prss2

  • Official Full Name

    protease, serine, 2 (trypsin 2)

  • Overview

    Trypsinogen is the precursor form or zymogen of the pancreatic enzyme trypsin. It is found in pancreatic juice, along with amylase, lipase, and chymotrypsinogen. It is activated by enteropeptidase, which is found in the intestinal mucosa, to form trypsin. Once activated, the trypsin can activate more trypsinogen into trypsin. Trypsin cleaves peptide bond on carboxyl side of basic amino acids. Serum trypsinogen is measured using a blood test. High levels are seen in acute pancreatitis, and cystic fibrosis.
  • Synonyms

    PRSS2 protease, serine, 2; PRSS2; TRYP; 8 anionic trypsin; pancreatic anionic trypsinogen; NP_777115.1; EC 3.4.21.4; Trypsinogen;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • NS0
  • Yeast
  • C
  • His
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRSS2-850H Active Recombinant Human PRSS2 E.coli N/A
Human PRSS2-316H Recombinant Human Protease, Serine, 2 (Trypsin 2) , His-tagged HEK293 His
Human PRSS2-7091H Recombinant Human PRSS2 protein, His & T7-tagged E.coli His/T7 Ile24~Asp241 (Accession # P07478)
Human PRSS2-3029H Recombinant Human PRSS2 protein(16-247aa(K23Q,S167G)), His-tagged E. coli C-His 16-247aa(K23Q,S167G)
Human PRSS2-6016H Recombinant Human PRSS2 Protein (Ile24-Asp241), N-His tagged E.coli N-His Ile24-Asp241
Human PRSS2-30H Active Recombinant Human PRSS2 Protein, His-tagged NS0 His
Human PRSS2-1367H Recombinant Human PRSS2 protein, His-SUMO-tagged E.coli His-SUMO 24-247aa
Mouse Prss2-909M Active Recombinant Mouse Prss2 protein, His-tagged HEK293 His Met1-Asn246
Mouse Prss2-7092M Recombinant Mouse Prss2 protein, His-tagged E.coli His Thr29~Gln240
Mouse PRSS2-2293MCL Recombinant Mouse PRSS2 cell lysate Human Cell N/A
Rat PRSS2-4739R Recombinant Rat PRSS2 Protein Mammalian Cell His
Rat Prss2-1992R Recombinant Rat Prss2 Protein, His-tagged E.coli N-His Val35-Thr242
Rat PRSS2-4398R-B Recombinant Rat PRSS2 Protein Pre-coupled Magnetic Beads HEK293
Rat PRSS2-2690R Recombinant Rat PRSS2 Protein (24-246 aa), His-tagged Yeast His 24-246 aa
Rat PRSS2-4398R Recombinant Rat PRSS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bovine PRSS2-6B Recombinant Bovine Trypsin N/A
Rhesus Macaque PRSS2-3637R Recombinant Rhesus monkey PRSS2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PRSS2-3455R Recombinant Rhesus Macaque PRSS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRSS2-3455R-B Recombinant Rhesus Macaque PRSS2 Protein Pre-coupled Magnetic Beads HEK293
Pig PRSS2-5408P Recombinant Pig PRSS2 Protein (Asp20-Ser247), C-His tagged Yeast C-His Asp20-Ser247
Pig PRSS2-493P Recombinant Pig PRSS2 Protein, His-tagged E.coli N-His Ile9-Asn231
Chicken PRSS2-6936C Recombinant Chicken PRSS2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Prss2 Related Articles
  • Prss2 Related Research Area

Prss2 involved in several pathways and played different roles in them. We selected most pathways Prss2 participated on our site, such as Neuroactive ligand-receptor interaction, Pancreatic secretion, Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prss2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionTAAR12G;GRIA2B;P2RY4;PRL;GABRG1;GALR2;GABRR2;GLRA2;S1PR2
Pancreatic secretionCELA3B;BST1;CCKAR;CLCA2;PLA2G10;ITPR1;RAC1;LOC780933;PLA2G2E
Protein digestion and absorptionSLC16A10;SLC8A2;CELA2A;SLC1A1;SLC3A1;PRSS1;PRSS2;ATP1A2;ATP1A4
Influenza AIFNA10;MX1;IFNGR1;MAPK9;BLB2;IVNS1ABP;IFNAR2;TNFRSF10D;HSPA8

Prss2 has several biochemical functions, for example, calcium ion binding, protein binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Prss2 itself. We selected most functions Prss2 had, and list some proteins which have the same functions with Prss2. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingCAPN2A;MYLZ3;SPATA21;ELTD1;PCDH2G8;NCS1;MYL1;NID2;PCDH1A6
protein bindingHLA-A;HIST1H4A;PCDH18;SNRPE;SYT4;SCAMP1;ULK1;FEZ1;PALB2
serine-type endopeptidase activityTMPRSS4B;PREP;HTRA3;PRSS59.1;IMMP1L;PIK3IP1;FURINB;GZMF;FURINA

Prss2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Prss2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Prss2.

Lin, JJ; Zhao, DM; et al. Transcriptome changes upon in vitro challenge with Mycobacterium bovis in monocyte-derived macrophages from bovine tuberculosis-infected and healthy cows. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 163:146-156(2015).
Mounzer, R; Whitcomb, DC; et al. Genetics of acute and chronic pancreatitis. CURRENT OPINION IN GASTROENTEROLOGY 29:544-551(2013).
  • Q&As
  • Reviews

Q&As (6)

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What is the current state of development for PRSS2? 12/30/2022

Drug development for PRSS2 is currently in clinical trials, including monoclonal antibodies against the PRSS2 receptor and inhibitors against the PRSS2 signaling pathway.

What is the relationship between PRSS2 protein and muscle wasting? 08/25/2022

Studies have shown that PRSS2 protein can inhibit the occurrence of muscle atrophy, but the specific mechanism is not clear.

Does PRSS2 protein play a role in cancer immunotherapy? 06/14/2022

PRSS2 protein plays an important role in tumor immunotherapy, which can activate the immune response of tumor cells, promote apoptosis of tumor cells and inhibit the proliferation of tumor cells.

What is the relationship between PRSS2 protein and cardiovascular disease? 02/25/2022

Studies have shown that PRSS2 protein may be associated with the development of cardiovascular diseases such as atherosclerosis and myocardial infarction.

How can I increase the expression level of PRSS2 protein? 01/17/2022

There is no direct way to increase the expression level of PRSS2 protein, but it can be improved by regulating gene expression and providing nutritional support.

How can PRSS2 be used as a biomarker in clinical practice? 10/28/2020

In clinical practice, the expression level of PRSS2 can be detected to predict disease progression and prognosis, and to guide the choice of treatment regimen.

Customer Reviews (3)

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Reviews
05/17/2022

    Good stability and consistency in the process of mass production.

    11/09/2021

      PRSS2 has an excellent expression system.

      08/12/2021

        PRSS2 has long-lasting effects and sustained release performance.

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