prtn3 Protein, proteinase 3


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Official Full Name proteinase 3
Background PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
Synonyms MBN; MBT; NP4; P29; PR3; ACPA; AGP7; PR-3; CANCA; C-ANCA; myeloblastin; C-ANCA antigen; wegener autoantigen; leukocyte proteinase 3; neutrophil proteinase 4; azurophil granule protein 7; serine proteinase, neutrophil; Wegener granulomatosis autoantigen; proteinase 3; NP-4; EC; EC 3.4.21
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Azurophil Granules
    • Human Neutrophil
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PRTN3-1996H Recombinant Human PRTN3 Protein, His-tagged E.coli His
    Human PRTN3-242H Native Human Proteinase 3 Human Azurophil Granules N/A
    Human PRTN3-243H Native Human Proteinase 3 Human Neutrophil N/A
    Human PRTN3-2797HCL Recombinant Human PRTN3 293 Cell Lysate HEK293 N/A
    Human PRTN3-31105TH Recombinant Human PRTN3 Wheat Germ N/A
    Human PRTN3-45H Recombinant Human PRTN3 protein, His-tagged HEK293 His
    Mouse PRTN3-13534M Recombinant Mouse PRTN3 Protein Mammalian Cell His
    Mouse Prtn3-6958M Recombinant Mouse Prtn3 protein, His-tagged E.coli His
    Rat Prtn3-6959R Recombinant Rat Prtn3 protein, His-tagged E.coli His

    prtn3 involved in several pathways and played different roles in them. We selected most pathways prtn3 participated on our site, such as C-MYB transcription factor network, Common Pathway of Fibrin Clot Formation, Formation of Fibrin Clot (Clotting Cascade), which may be useful for your reference. Also, other proteins which involved in the same pathway with prtn3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    C-MYB transcription factor network SLC25A3; SKI; ADORA2B; PRTN3; ELANE; CREBBP; COL1A2; MYB; CDKN1B; MYC
    Common Pathway of Fibrin Clot Formation PROCA; PROCR; F13A1B; SERPINA1L; CD177; CFHL3; CFHL2; LOC100514666; F13A1A.1; SERPINE2
    Formation of Fibrin Clot (Clotting Cascade) F13A1B; PRTN3; PROCA; CFHL1; PROCR; SERPINA1L; CD177; F3A; F9A; LOC100514666
    Hemostasis LRRC16A; ITPK1; MERTK; MGC173646; SCG3; SLC7A11; CENPE; HBG2; WDR1; KIF2C

    prtn3 has several biochemical functions, for example, enzyme binding, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by prtn3 itself. We selected most functions prtn3 had, and list some proteins which have the same functions with prtn3. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding PCCA; NFKBIA; HDAC10; CBS; Ar; CLSTN2; SUDS3; FAM84B; HSPA6; HSPA2
    serine-type endopeptidase activity PRSS7; TPSB2; PRSS2; CFD; PCSK9; PCSK4; GZMA; GZMM; PRSS12; PREPL
    serine-type peptidase activity TPP1; KLK11; Prss32; HTRA1B; CMA1; DPP6B; SEC11C; KLK1B9; DPP10; OVCH2

    prtn3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with prtn3 here. Most of them are supplied by our site. Hope this information will be useful for your research of prtn3.

    SMAD3; A2M; P/V/C

    Alberici, F; Martorana, D; et al. Genetics of ANCA-associated vasculitides: HLA and beyond. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 32:S90-S97(2014).
    Lyons, PA; Rayner, TF; et al. Genetically Distinct Subsets within ANCA-Associated Vasculitis. NEW ENGLAND JOURNAL OF MEDICINE 367:214-223(2012).

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