PRTN3

  • Official Full Name

    proteinase 3

  • Overview

    PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
  • Synonyms

    MBN; MBT; NP4; P29; PR3; ACPA; AGP7; PR-3; CANCA; C-ANCA; myeloblastin; C-ANCA antigen; wegener autoantigen; leukocyte proteinase 3; neutrophil proteinase 4; azurophil granule protein 7; serine proteinase, neutrophil; Wegener granulomatosis autoantigen; proteinase 3; NP-4; EC 3.4.21.76; EC 3.4.21;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human Azurophil Granules
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Neutrophils
  • Peripheral blood leukocytes
  • Wheat Germ
  • C
  • His
  • Myc
  • DDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRTN3-31105TH Recombinant Human PRTN3 Wheat Germ N/A 256 amino acids
Human PRTN3-1996H Recombinant Human PRTN3 Protein, His-tagged E.coli His
Human PRTN3-45H Recombinant Human PRTN3 protein, His-tagged HEK293 His
Human PRTN3-2797HCL Recombinant Human PRTN3 293 Cell Lysate HEK293 N/A
Human PRTN3-301563H Recombinant Human PRTN3 protein, GST-tagged E.coli GST Asn89-Thr150
Human PRTN3-242H Native Human Proteinase 3 Human Azurophil Granules N/A
Human PRTN3-3376H Recombinant Human PRTN3 protein, His&Myc-tagged E.coli His&Myc 28-248aa
Human PRTN3-0257H Recombinant Human PRTN3 protein, His-tagged HEK293 His Ile28-Pro256
Human PRTN3-406HF Recombinant Full Length Human PRTN3 Protein In Vitro Cell Free System 256 amino acids
Human PRTN3-243H Native Human PRTN3 Protein Neutrophils
Human PRTN3-1779H Recombinant Human PRTN3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PRTN3-252H Recombinant Human PRTN3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human PRTN3-1779H-B Recombinant Human PRTN3 Protein Pre-coupled Magnetic Beads HEK293
Human PRTN3-1556HFL Recombinant Full Length Human PRTN3 Protein, C-Flag-tagged Mammalian cells Flag
Human PRTN3-6018H Recombinant Human PRTN3 Protein E.coli Tag Free
Human PRTN3-01H Native Human PRTN3 Protein Peripheral blood leukocytes
Human PRTN3-6019H Recombinant Human PRTN3 Protein (Ala26-Arg249), C-His tagged Mammalian cells C-His Ala26-Arg249
Human PRTN3-2633H Recombinant Human PRTN3 Protein, His-tagged E.coli N-His Ile28-Arg248
Human PRTN3-6020H Recombinant Human PRTN3 Protein (Ile28-Arg249), N-GST tagged E.coli N-GST Ile28-Arg249
Mouse PRTN3-13534M Recombinant Mouse PRTN3 Protein Mammalian Cell His
Mouse Prtn3-6958M Recombinant Mouse Prtn3 protein, His-tagged E.coli His Ala24~Leu249
Mouse PRTN3-7193M Recombinant Mouse PRTN3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PRTN3-7193M-B Recombinant Mouse PRTN3 Protein Pre-coupled Magnetic Beads HEK293
Rat Prtn3-6959R Recombinant Rat Prtn3 protein, His-tagged E.coli His Ala18~His246
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PRTN3 involved in several pathways and played different roles in them. We selected most pathways PRTN3 participated on our site, such as C-MYB transcription factor network, Common Pathway of Fibrin Clot Formation, Formation of Fibrin Clot (Clotting Cascade), which may be useful for your reference. Also, other proteins which involved in the same pathway with PRTN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
C-MYB transcription factor networkCBX4;MYOD1;SLC25A3;LECT2;TOM1;PPID;CEBPA;CDK6;CSF1R
Common Pathway of Fibrin Clot FormationPROCA;F13A1B;CFHL3;CFHL4;PRTN3;SERPINA1L;PROCR;CFHL1;SERPINE2
Formation of Fibrin Clot (Clotting Cascade)CD177;LOC100514666;CFHL3;CFHL4;F9B;PROCA;F9A;CFHL2;SERPINA1L
HemostasisCD84;KCNMA1;S100A10B;BA1L;GRB7;CABLES2;C6orf25;SLC3A2B;MAFG

PRTN3 has several biochemical functions, for example, enzyme binding, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRTN3 itself. We selected most functions PRTN3 had, and list some proteins which have the same functions with PRTN3. You can find most of the proteins on our site.

Function Related Protein
enzyme bindingEGFR;ECM1;THRB;DNM2;DDX5;FOXO4;APOA5;NLRP1;UGT1A3
serine-type endopeptidase activityPROC;Gzmg;HPN;TMPRSS11F;GZMK;CTSC;KLK11;PIK3IP1;CFB
serine-type peptidase activityELA2;TPSAB1;ELA3L;F7;Prss32;TMPRSS13A;TMPRSS4B;NAALAD2;EGFBP2

PRTN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRTN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRTN3.

SMAD3; A2M; P/V/C

Research Area

Related articles

Alberici, F; Martorana, D; et al. Genetics of ANCA-associated vasculitides: HLA and beyond. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 32:S90-S97(2014).
Lyons, PA; Rayner, TF; et al. Genetically Distinct Subsets within ANCA-Associated Vasculitis. NEW ENGLAND JOURNAL OF MEDICINE 367:214-223(2012).
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Customer Reviews (3)

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Reviews
08/16/2022

    Very good after-sales service to get my experiments going!

    07/21/2022

      The technician modified my experimental protocol so that my experiment went smoothly.

      02/04/2022

        The protein composition was stable and concentrated, allowing me to obtain satisfactory experimental results.

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