Native Human PRTN3 Protein

• Cat.No.: PRTN3-243H
• Product Overview: Native human PRTN3 protein purified from human neutrophils, prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. Extinction Coefficient: 1.0

Specification

• Description: Enables enzyme binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including mature conventional dendritic cell differentiation; membrane protein ectodomain proteolysis; and neutrophil extravasation. Located in azurophil granule lumen; cytosol; and plasma membrane raft. Colocalizes with plasma membrane.
• Source: Neutrophils
• Species: Human
• Molecular Mass: 29 kDa
• Purity: ≥ 95% by SDS-PAGE.
• Stability: > 1 year
• Storage: ≤ -70 centigrade
• Storage Buffer: Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl

Gene Information

• Gene Name: PRTN3 proteinase 3 [ Homo sapiens (human) ]
• Official Symbol: PRTN3
• Synonyms: PRTN3; proteinase 3; MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA; myeloblastin; C-ANCA antigen; Wegener granulomatosis autoantigen; azurophil granule protein 7; leukocyte proteinase 3; neutrophil proteinase 4; serine proteinase, neutrophil; wegener autoantigen; EC 3.4.21.76
• Gene ID: 5657
• mRNA Refseq: NM_002777.4
• Protein Refseq: NP_002768.3
• MIM: 177020
• UniProt ID: P24158