PTGDR
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Official Full Name
prostaglandin D2 receptor (DP)
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Background
The protein encoded by this gene is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+.Knockout studies in mice suggest that the ligand of this receptor,prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses. -
Synonyms
PTGDR; prostaglandin D2 receptor (DP); prostaglandin D2 receptor; DP; DP1; PTGDR1; AS 1; AS1; ASRT 1; ASRT1; MGC49004; OTTHUMP00000178986; PD2R_HUMAN; PGD receptor; PGD2 receptor; Prostanoid DP receptor;
- Involved Pathway
- Protein Function
- Interacting Protein
PTGDR involved in several pathways and played different roles in them. We selected most pathways PTGDR participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGDR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | GPR50;OPRD1;MTNR1BB;CHRNA5;CYSLTR2;GPR156;NPFFR1L2;P2RX3;TAAR12C |
PTGDR has several biochemical functions, for example, prostaglandin D receptor activity, prostaglandin J receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGDR itself. We selected most functions PTGDR had, and list some proteins which have the same functions with PTGDR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| prostaglandin D receptor activity | PTGDR2;PTGDR |
| prostaglandin J receptor activity | PTGDR;PTGDR2 |
| protein binding | CAMK2D;ATXN2;OCLN;NARG1;ATF7IP;LINGO1;RBFOX2;MKRN3;COMT |
PTGDR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGDR here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGDR.
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