PTGS1
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Official Full Name
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
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Overview
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] -
Synonyms
PTGS1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1; prostaglandin G/H synthase 1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Human
- Mouse
- Ovis aries (Sheep)
- Rat
- Sheep
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Insect cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Ram seminal versicles
- Ram seminal vesicles
- Flag
- His
- Fc
- Avi
- T7
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
PTGS1 involved in several pathways and played different roles in them. We selected most pathways PTGS1 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | CYP2Y3;PTGDSA;CYP1A2;GPX1A;CYP2E1;GPX6;CYP4B1;PLA2G4D;PTGS2A |
| Metabolic pathways | PI4KB;AMACR;ALG14;CYP19A1A;ALDH3A1;NMNAT1;CNDP2;UQCRC1;UROD |
| Platelet activation | ITPR1;PLCB4;LCP2;PPP1R12A;PIK3CD;MAPK12;PPP1CC;GNAI3;GNAQ |
| Serotonergic synapse | PLA2G4F;GNG12;GNG13;GNG7;PLCB2;ALOX12E;KCNN2;HTR1F;GNG10 |
| Regulation of lipolysis in adipocytes | AKT1;NPY1R;GNAI1;AKT2;GNAI3;TSHB;LOC100328615;PIK3R2;PRKG1 |
PTGS1 has several biochemical functions, for example, dioxygenase activity, heme binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGS1 itself. We selected most functions PTGS1 had, and list some proteins which have the same functions with PTGS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dioxygenase activity | KDM6A;PHYHD1;P4HA1B;JMJD1C;MINA;ALOX5A;KDM3A;KDM5BB;KDM4B |
| heme binding | CYP7A1A;BA1;CYGB1;CYP39A1;JAK2;NOX4;CYP3A5;CYP26C1;NOS1 |
| lipid binding | APOEA;HSP12;O3far1;OSBPL11;S100A13;APOEB;APOA2;CLINT1;ACBD5A |
| metal ion binding | RXRAA;ZSCAN4C;PATZ1;CD209B;SP7;CHEK2;ZDHHC18A;B3GAT2;CYP2D9 |
| peroxidase activity | PXDN;GPX6;GPX8;IPCEF1;TPO;GPX7;GPX4B;GPX4A;PRDX5 |
| prostaglandin-endoperoxide synthase activity | PTGS2B;PTGS2A;PTGS2;PTGS1 |
PTGS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGS1.
Dlg4; arachidonic acid; diclofenac
Research Area
- Reviews
- Q&As
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