PTGS1

  • Official Full Name

    prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

  • Overview

    This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
  • Synonyms

    PTGS1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1; prostaglandin G/H synthase 1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Human
  • Mouse
  • Ovis aries (Sheep)
  • Rat
  • Sheep
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Insect cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Ram seminal versicles
  • Ram seminal vesicles
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTGS1-733H Recombinant Human PTGS1 protein, His & T7-tagged E.coli His/T7 Gly367~Leu599 (Accession # P23219)
Human PTGS1-2706HCL Recombinant Human PTGS1 293 Cell Lysate HEK293 N/A
Human PTGS1-045H Recombinant Human PTGS1 Protein, His-tagged Insect cell His 24-599
Human PTGS1-012H Recombinant Human PTGS1 Protein, His-tagged Insect Cells His 24-599
Human PTGS1-865H Recombinant Human PTGS1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTGS1-6072H Recombinant Human PTGS1 Protein (Gly367-Leu599), N-His tagged E.coli N-His Gly367-Leu599
Human PTGS1-593HFL Recombinant Full Length Human PTGS1 Protein, C-Flag-tagged Mammalian cells Flag
Human PTGS1-1796H-B Recombinant Human PTGS1 Protein Pre-coupled Magnetic Beads HEK293
Human PTGS1-1796H Recombinant Human PTGS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ptgs1-734M Recombinant Mouse Ptgs1 protein, His-tagged E.coli His Glu407~Leu602 (Accession # P22437)
Mouse PTGS1-13650M Recombinant Mouse PTGS1 Protein Mammalian Cell His
Mouse Ptgs1-5225M Recombinant Mouse Ptgs1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PTGS1-7260M Recombinant Mouse PTGS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PTGS1-7260M-B Recombinant Mouse PTGS1 Protein Pre-coupled Magnetic Beads HEK293
Rat Ptgs1-819R Recombinant Rat Ptgs1 protein, His & T7-tagged E.coli His/T7 Pro23~Tyr277 (Accession # Q63921)
Rat PTGS1-4816R Recombinant Rat PTGS1 Protein Mammalian Cell His
Rat PTGS1-4475R Recombinant Rat PTGS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTGS1-4475R-B Recombinant Rat PTGS1 Protein Pre-coupled Magnetic Beads HEK293
Ovis aries (Sheep) RFL34487OF Recombinant Full Length Sheep Prostaglandin G/H Synthase 1(Ptgs1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-600)
Sheep PTGS1-58S Native Sheep PTGS1 Protein Ram seminal vesicles
Sheep PTGS1-141S Native Sheep PTGS1 Protein Ram seminal versicles
Zebrafish PTGS1-9463Z Recombinant Zebrafish PTGS1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTGS1 Related Research Area

PTGS1 involved in several pathways and played different roles in them. We selected most pathways PTGS1 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismGPX5;CYP4F2;ALOX12B;PLA2G4F;PTGS2A;CYP2J2;CYP2P8;CYP2B6;PTGESL
Metabolic pathwaysALOX12;MVK;MAT2B;NT5C1AA;IDH3G;ALDH1A2;ATP6V0CB;PCYT1BB;CBR1L
Platelet activationPPP1CB;RHOA;ARHGEF1;ITGA2B;GNAI1;TBXA2R;GUCY1A3;BTK;PLCB4
Serotonergic synapseHTR3E;CYP2D10;PLA2G4D;GNG12;GNG3;PTGS2;GABRB2;TRPC1;PRKACA
Regulation of lipolysis in adipocytesPRKACB;INS1;GNAI1;IRS1;PRKG2;GNAS;TSHR;INS2;IRS4

PTGS1 has several biochemical functions, for example, dioxygenase activity, heme binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGS1 itself. We selected most functions PTGS1 had, and list some proteins which have the same functions with PTGS1. You can find most of the proteins on our site.

Function Related Protein
dioxygenase activityKDM5D;MINA;ADOB;ALKBH6;BCO1;ADOA;ALOX5B.3;LEPREL1;KDM3A
heme bindingHBZ;CYP46A1.3;CYP3C4;CYP51A1;CYP27B1;FAM84B;EPX;CYP2A13;CYP2B6
lipid bindingPACSIN1B;FABP9;BPIFA3;GLTP;BPIFB4;ACOT11;MTTP;BAD;SH3GL2
metal ion bindingPOLK;TGM4;CHN2;KLF18;LMO7A;CHORDC1;ANTXR2A;DPH3P1;AGFG1
peroxidase activityPRDX5;GPX1B;GPX4A;PTGS2A;DUOX2;PXDN;GPX6;CYGB;GPX7
prostaglandin-endoperoxide synthase activityPTGS2;PTGS1;PTGS2B;PTGS2A

PTGS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGS1.

Dlg4; arachidonic acid; diclofenac

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