PTGS2

  • Official Full Name

    prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

  • Overview

    Cytochrome c oxidase subunit II, also known as COX2, is a human protein and gene. that belongs to cytochrome c oxidase subunit II protein family. It is sometimes confused with the cyclooxygenase enzyme COX-2.
  • Synonyms

    Ptgs2; prostaglandin-endoperoxide synthase 2; COX2; Cox-2; PHS-2; Pghs2; TIS10; PGHS-2; PES-2; PHS II; gripghs; PGH synthase 2; cyclooxygenase 2; cyclooxygenase-2; prostaglandin H2 synthase 2; glucocorticoid-regulated inflammatory cyclooxygenase; macrophage activation-associated marker protein P71/73; prostaglandin G/H synthase, Tis10;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Chicken
  • Human
  • Mouse
  • Rat
  • Sheep
  • E.coli
  • HEK293
  • Insect cell
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf21 Insect Cell
  • Sheep placenta
  • C
  • His
  • Flag|His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTGS2-30H Active Recombinant Human PTGS2 protein, His-tagged Insect Cell His
Human PTGS2-26360TH Recombinant Human PTGS2, His-tagged His
Human PTGS2-32H Recombinant Human PTGS2 protein, FLAG/His-tagged Insect Cell Flag/His
Human PTGS2-678H Recombinant Human PTGS2 protein, His & T7-tagged E.coli His/T7 Gly418~Asp589 (Accession # P35354)
Human PTGS2-677H Recombinant Human PTGS2 protein, His & T7-tagged E.coli His/T7 Phe187~Asn425 (Accession # P35354)
Human PTGS2-523H Recombinant Human PTGS2 Sf21 Insect Cell N/A
Human PTGS2-857H Recombinant Human PTGS2 protein(Met1-Leu604), His-tagged Insect Cells C-His Met1-Leu604
Human PTGS2-643HCL Recombinant Human PTGS2 cell lysate Insect Cell N/A
Human PTGS2-2640H Recombinant Human PTGS2 Protein, His-tagged E.coli N-His Asn19-Asp589
Human PTGS2-01H Active Recombinant Human PTGS2 2N580A Mutant Protein, His-tagged Insect Cell His
Human PTGS2-857HAF488 Recombinant Human PTGS2 Protein, His-tagged, Alexa Fluor 488 conjugated Insect Cells His 597
Human PTGS2-752H Recombinant Human PTGS2 Protein (18-601 aa), His-tagged E.coli His 18-601 aa
Human PTGS2-6074H Recombinant Human PTGS2 Protein (Phe187-Asn425), N-His tagged E.coli N-His Phe187-Asn425
Human PTGS2-857HAF555 Recombinant Human PTGS2 Protein, His-tagged, Alexa Fluor 555 conjugated Insect Cells His 597
Human PTGS2-080H Active Recombinant Human PTGS2 Protein, His-tagged Insect cell His 20-604
Human PTGS2-857HAF647 Recombinant Human PTGS2 Protein, His-tagged, Alexa Fluor 647 conjugated Insect Cells His 597
Human PTGS2-857HF Recombinant Human PTGS2 Protein, His-tagged, FITC conjugated Insect Cells His 597
Human PTGS2-63H Recombinant Human PTGS2 Protein, His-tagged Insect Cell His 20-604
Mouse PTGS2-13651M Recombinant Mouse PTGS2 Protein Mammalian Cell His
Mouse Ptgs2-679M Recombinant Mouse Ptgs2 protein, His-tagged E.coli His Tyr240~Leu351
Mouse PTGS2-7261M-B Recombinant Mouse PTGS2 Protein Pre-coupled Magnetic Beads HEK293
Mouse PTGS2-7261M Recombinant Mouse PTGS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTGS2-4817R Recombinant Rat PTGS2 Protein Mammalian Cell His
Rat PTGS2-4476R Recombinant Rat PTGS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTGS2-4476R-B Recombinant Rat PTGS2 Protein Pre-coupled Magnetic Beads HEK293
Sheep PTGS2-046S Active Recombinant Sheep PTGS2 Protein Insect cell 24-599
Sheep PTGS2-010S Active Recombinant Sheep PTGS2 Protein Insect Cells 24-599
Sheep PTGS2-57S Native Sheep PTGS2 Protein Sheep placenta
Chicken PTGS2-4016C Recombinant Chicken PTGS2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTGS2 Related Articles
  • PTGS2 Related Research Area

PTGS2 involved in several pathways and played different roles in them. We selected most pathways PTGS2 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismCYP2U1;CYP2C39;FAM213B;CYP2Y3;ALOX5B.3;PTGS1;PTGES3A;CYP2B6;PLA2G10
Metabolic pathwaysTPH1;DAO.2;NDUFB3;TKTL2;PNP6;CTPS1A;GULO;ALAD;IDO2
NF-kappa B signaling pathwayBIRC3;PIDD1;PTGS2;BCL2;CD14;CARD11;IRAK1;DDX58;Ccl21c
VEGF signaling pathwayHSPB1;PLA2G4C;BAD;PTGS2;PTK2AA;HRAS;CDC42;PPP3CCA;PPP3CA
TNF signaling pathwayMAP3K14;FADD;IL18R1;CCL20;IL15;MAP3K7;FAS;MAP2K7;TNF
Retrograde endocannabinoid signalingPLCB3;PTGS2;GABRD;MAPK12;GNG12;GABRA6;GRIA4;SLC17A8;GABRA3
Serotonergic synapseGNAI2;SLC18A1;PLA2G4C;GNAQ;MAPK3;GNG13;TPH1;PTGS2;PLA2G4A
Ovarian steroidogenesisCYP2J6;INS2;HSD17B2;Adcy4;HSD3B6;CYP2J5;GDF9;HSD17B1;INS
Oxytocin signaling pathwayMYLK2;RYR1;RYR3;CACNA2D2;NOS3;PPP1CB;CAMK2G;RAF1;NPR2
Regulation of lipolysis in adipocytesPTGER3;GNAI2;Adcy4;PRKACA;AKT2;PNPLA2;AKT1;IRS2;PIK3CB
LeishmaniasisHLA-DRB4;FCGR2A;HLA-DQB1;HLA-DRB3;ITGB2L;HLA-DRB5;PRKCB;TAB2;HLA-DPA1
Pathways in cancerLEF1;MMP9;HDAC2;APC;WNT6;VEGFC;ROCK2;GNB4;ROCK1
Chemical carcinogenesisGSTK1;UGT2A1;SULT2A1;Nat3;GSTO2;CCBL1;CYP2C50;ALDH3B1;GSTM2
MicroRNAs in cancerEZR;MDM2;ITGB3;BAK1;ERBB2;PRKCA;CCND2;PRKCG;NOTCH4
Small cell lung cancerNFKBIA;LAMC2;NFKB1;LAMA2;PIK3R3;RELA;BIRC7;AKT1;XIAP

PTGS2 has several biochemical functions, for example, dioxygenase activity, heme binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGS2 itself. We selected most functions PTGS2 had, and list some proteins which have the same functions with PTGS2. You can find most of the proteins on our site.

Function Related Protein
dioxygenase activityOGFOD2;ASPHD1;MINA;PHF2;ALOX5B.3;ALOX5A;ALOX8;KDM4B;HPDA
heme bindingCYGB2;CYP4A11;HBQ1;NOS2;CYP19A1B;CBSA;CYP2C50;CYP2A6;PTGES2
lipid bindingFABP7A;BPIFB4;APOH;PLUNC;FABP11B;CETP;FABP11A;FAM123A;S100A13
metal ion bindingZFP2;ZNRF2B;OGDH;ZNF155;PDE4D;CYP4A14;ZNF383;RPS27A;SUV39H1A
peroxidase activityGPX4A;PRDX1;IPCEF1;GPX4B;GPX6;PTGS2;PTGS1;PXDN;DUOX2
prostaglandin-endoperoxide synthase activityPTGS1;PTGS2A;PTGS2B;PTGS2

PTGS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGS2.

arachidonic acid; ns398; q9wmx2-pro_0000037550; LRRK2

Addison, JB; Koontz, C; et al. KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells. CANCER RESEARCH 75:344-355(2015).
Jang, YJ; Park, JI; et al. Cumulus Cell-Expressed Type I Interferons Induce Cumulus Expansion in Mice. BIOLOGY OF REPRODUCTION 92:-(2015).
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